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Cancer Research and Treatment > Volume 35(3); 2003 > Article
Cancer Research and Treatment 2003;35(3): 267-273. doi: https://doi.org/10.4143/crt.2003.35.3.267
Paclitaxel and Cisplatin Combination Chemotherapy in Pretreated Breast Cancer
Joo Hyuk Sohn, Yong Tai Kim, Sun Young Rha, Nae Choon Yoo, Jae Kyung Roh, Byung Soo Kim, Chang Ok Suh, Gwi Eon Kim, Woo Ick Jang, Hyun Cheol Chung
1Department of Internal Medicine, Yonsei University Collegeof Medicine, Korea. unchung8@yumc.yonsei.ac.kr
2Yonsei Cancer Center, Yonsei University College of Medicine,Korea.
3Cancer Metastasis Research Center, Yonsei University Collegeof Medicine, Korea.
4Brain Korea 21 Project for Medical Science, YonseiUniversity College of Medicine, Korea.
5Lilly Korea, Ltd., Seoul, Korea.
  Published online: June 30, 2003.
ABSTRACT
PURPOSE:
A single institute trial of combination chemotherapy, with paclitaxel and cisplatin, in patients with metastatic breast cancer, having failed previous combination chemotherapy, was performed.
MATERIALS AND METHODS:
Patients were only eligible for this study if there disease had progressed, following treatment with previous chemotherapy, in either an adjuvant or a metastatic setting. Paclitaxel 175 mg/m2 was administered as a 3-hour continuous infusion on day 1, and cisplatin 80 mg/m2 was administered for 2 hours on day 2, with adequate hydration. This was repeated every 3 weeks, and continued until one of the following events occurred: disease progression, unacceptable adverse effect or treatment refusal by the patient. Intercurrent palliative radiotherapy, or concurrent hormonal therapy, was permitted, depending on each patient's status. All the endpoints were evaluated under the principle of intention to treat analysis.
RESULTS:
A total of 24 patients entered the study, and 18 had at least one measurable lesion, but 6 did not. The objective response rate of the 18 patients was 50%(9/18). Two were complete responses and seven showed partial responses. The median response duration, progression free and overall survival were 5.3 months (range, 4~18), 6 months (95% CI, 5~7) and 12 months (95% CI, 7~17), respectively. 67% of the planned dose was administered. Out of a total 135 cycles administered, about 20% of cycles showed grade 3 or 4 leukopenia and 7% showed grade 3 thrombocytopenia. Two patients suffered from pneumonia, and one experienced neutropenic fever. Mucositis, greater than grade 3, existed in three cases. No treatment related deaths were reported.
CONCLUSION:
The combination chemotherapy, with paclitaxel and cisplatin, was active in the treatment of metastatic breast cancer patients having failed previous chemotherapy.
Key words: Breast neoplasm;Salvage;Chemotherapy;Paclitaxel;Cisplatin
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