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J Korean Cancer Assoc > Volume 28(6); 1996 > Article
Journal of the Korean Cancer Association 1996;28(6): 988-996.
유방암에서 MMM 을 이용한 수술전 유도화학요법
장일성, 김경헌, 설지영, 윤완희, 배진선, 손기섭
The Induction Chemotherapy with MMM Regimen on Breast Cancer
Eil Sang Chang, Kyung Hun Kim, Ji Young Sul, Wan Hee Yoon, Chin Sun Bae, Ki Sub Son
At the department of general surgery, college of medicine Chungnam National University, from Mar. 1993 to Oct. 1995, 34 patients with breast cancer were treated with the primary combination chemotherapy with MMM regimen. The MMM regimen was consisted of mitoxantrone, methotrexate, given on days 1 and 21 at a dose of 7 mg/§³, 35 mg/§³ respectively, and Mitomycin-C, given on days 1 at a dose of 7 mg/§³. After 3 cycles of primary chemotherapy, operation was performed in 2 weeks. The results were as follows; 1) The most prevalent age was fifth decade in 12 cases(35.3%) and premenopause was 25 cases(73.5% ). 2) After primary chemotherapy and operation, the axillary lymph node metastasis was not involved in 21 cases(61.8%). 3) The histopathological diagnostic methods were needle biposy in 20 cases(58.8%) and fine needle aspiration cytology in 14 cases(41.2%). 4) After primary chemotherapy, overall objective response rate was 61.8% with complete response, 11.8% and partial response, 50.0%. 5) The down staging effect was happened in 19 cases(55.9%). 6) After primary chemotherapy, berast-preserving operation was performed in 22 cases (64.7% ). 7) Of the side effect, amenorrhea was significant and present in 25 cases, whole premenopausal women.
Key words: Breast cancer, Primary chemotherapy, Mitoxantrone
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