Cancer Research and Treatment

SPECIAL ARTICLE 2019 March 18 Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2016
Purpose This study presents the 2016 nationwide cancer statistics in Korea, including cancer incidence, survival, prevalence, and mortality. Materials and Methods Cancer incidence data from 1999 to 2016 were obtained from the Korea National Cancer Incidence Database and follo...

SPECIAL ARTICLE 2019 March 18 Prediction of Cancer Incidence and Mortality in Korea, 2019
Purpose This study aimed to report on cancer incidence and mortality for the year 2019 to estimate Korea’s current cancer burden. Materials and Methods Cancer incidence data from 1999 to 2016 were obtained from the Korea National Cancer Incidence Database, and cancer mortali...

ORIGINAL ARTICLE 2018 June 1 Preclinical Efficacy of [V⁴ Q⁵ ]dDAVP, a Second Generation Vasopressin Analog, on Metastatic Spread and Tumor-Associated Angiogenesis in Colorectal Cancer
Purpose Control of metastatic spread of colorectal cancer (CRC) remains as a major therapeutic challenge. [V4 Q5 ]dDAVP is a vasopressin peptide analog with previously reported anticancer activity against carcinoma tumors. By acting as a selective agonist of arginine vasopressi...

ORIGINAL ARTICLE 2018 June 6 Pan-Pim Kinase Inhibitor AZD1208 Suppresses Tumor Growth and Synergistically Interacts with Akt Inhibition in Gastric Cancer Cells
Purpose Pim kinases are highly conserved serine/threonine kinases, and different expression patterns of each isoform (Pim-1, Pim-2, and Pim-3) have been observed in various types of human cancers, including gastric cancer. AZD1208 is a potent and selective inhibitor that affect...

Current Issue

Volume 51(2); Apr 2019

Volume 51(1); January 2019

Volume 50(4); October 2018

Obituary

415

In Memoriam: Waun Ki Hong, M.D. (August 13, 1942-January 2, 2019)

Hoon-Kyo Kim

Cancer Res Treat. 2019;51(2):415-416. Published online March 18, 2019 DOI: https://doi.org/10.4143/crt.2019.149

Special Articles

417

Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2016

Kyu-Won Jung, Young-Joo Won, Hyun-Joo Kong, Eun Sook Lee, The Community of Population-Based Regional Cancer Registries

Cancer Res Treat. 2019;51(2):417-430. Published online March 18, 2019 DOI: https://doi.org/10.4143/crt.2019.138

431

Prediction of Cancer Incidence and Mortality in Korea, 2019

Kyu-Won Jung, Young-Joo Won, Hyun-Joo Kong, Eun Sook Lee

Cancer Res Treat. 2019;51(2):431-437. Published online March 18, 2019 DOI: https://doi.org/10.4143/crt.2019.139

Original Articles

438

Preclinical Efficacy of [V⁴ Q⁵ ]dDAVP, a Second Generation Vasopressin Analog, on Metastatic Spread and Tumor-Associated Angiogenesis in Colorectal Cancer

Juan Garona, Natasha T. Sobol, Marina Pifano, Valeria I. Segatori, Daniel E. Gomez, Giselle V. Ripoll, Daniel F. Alonso

Cancer Res Treat. 2019;51(2):438-450. Published online June 1, 2018 DOI: https://doi.org/10.4143/crt.2018.040

Cited By 1

451

Pan-Pim Kinase Inhibitor AZD1208 Suppresses Tumor Growth and Synergistically Interacts with Akt Inhibition in Gastric Cancer Cells

Miso Lee, Kyung-Hun Lee, Ahrum Min, Jeongeun Kim, Seongyeong Kim, Hyemin Jang, Jee Min Lim, So Hyeon Kim, Dong-Hyeon Ha, Won Jae Jeong, Koung Jin Suh, Yae-Won Yang, Tae Yong Kim, Do-Youn Oh, Yung-Jue Bang, Seock-Ah Im

Cancer Res Treat. 2019;51(2):451-463. Published online June 6, 2018 DOI: https://doi.org/10.4143/crt.2017.341

Cited By 1

464

Combination Treatment of Stereotactic Body Radiation Therapy and Immature Dendritic Cell Vaccination for Augmentation of Local and Systemic Effects

Chul Won Choi, Min Ho Jeong, You-Soo Park, Cheol-Hun Son, Hong-Rae Lee, Eun-Kyoung Koh

Cancer Res Treat. 2019;51(2):464-473. Published online June 6, 2018 DOI: https://doi.org/10.4143/crt.2018.186

Cited By 1

474

Long-term Outcomes of One Stage Surgery Using Transanal Colorectal Tube for Acute Colorectal Obstruction of Stage II/III Distal Colon Cancer

Yusuke Okuda, Tomonori Yamada, Yoshikazu Hirata, Takaya Shimura, Ryuzo Yamaguchi, Eiji Sakamoto, Satoshi Sobue, Takahiro Nakazawa, Hiromi Kataoka, Takashi Joh

Cancer Res Treat. 2019;51(2):474-482. Published online June 6, 2018 DOI: https://doi.org/10.4143/crt.2018.059

483

The Lymphatic Drainage Pattern of Internal Mammary Sentinel Lymph Node Identified by Small Particle Radiotracer (^99mTc-Dextran 40) in Breast

Xiao-Shan Cao, Guo-Ren Yang, Bin-Bin Cong, Peng-Fei Qiu, Yong-Sheng Wang

Cancer Res Treat. 2019;51(2):483-492. Published online June 11, 2018 DOI: https://doi.org/10.4143/crt.2018.062

493

EGFR Mutation Is Associated with Short Progression-Free Survival in Patients with Stage III Non-squamous Cell Lung Cancer Treated with Concurrent Chemoradiotherapy

Song Ee Park, Jae Myoung Noh, You Jin Kim, Han Sang Lee, Jang Ho Cho, Sung Won Lim, Yong Chan Ahn, Hongryull Pyo, Yoon-La Choi, Joungho Han, Jong-Mu Sun, Se Hoon Lee, Jin Seok Ahn, Keunchil Park, Myung-Ju Ahn

Cancer Res Treat. 2019;51(2):493-501. Published online June 18, 2018 DOI: https://doi.org/10.4143/crt.2018.125

Cited By 1

502

Efficacy and Safety of Afatinib for EGFR-mutant Non-small Cell Lung Cancer, Compared with Gefitinib or Erlotinib

Youjin Kim, Se-Hoon Lee, Jin Seok Ahn, Myung-Ju Ahn, Keunchil Park, Jong-Mu Sun

Cancer Res Treat. 2019;51(2):502-509. Published online June 13, 2018 DOI: https://doi.org/10.4143/crt.2018.117

510

Phase I Dose-Finding Study of OPB-111077, a Novel STAT3 Inhibitor, in Patients with Advanced Hepatocellular Carcinoma

Changhoon Yoo, Jihoon Kang, Ho Yeong Lim, Jee Hyun Kim, Myung-Ah Lee, Kyung-Hun Lee, Tae-You Kim, Baek-Yeol Ryoo

Cancer Res Treat. 2019;51(2):510-518. Published online June 13, 2018 DOI: https://doi.org/10.4143/crt.2018.226

519

A Comprehensive Assessment of the Racial and Ethnic Disparities in the Incidence of Gastric Cancer in the United States, 1992-2014

Qiang Yao, Xiaona Qi, Wen Cheng, Shao-Hua Xie

Cancer Res Treat. 2019;51(2):519-529. Published online June 19, 2018 DOI: https://doi.org/10.4143/crt.2018.146

530

Increased Risk of Osteoporosis in Gastric Cancer Survivors Compared to General Population Control: A Study with Representative Korean Population

Su-Min Jeong, Dong Wook Shin, Ji Eun Lee, Sang-Man Jin, Sung Kim

Cancer Res Treat. 2019;51(2):530-537. Published online June 27, 2018 DOI: https://doi.org/10.4143/crt.2018.164

538

Diabetes Medication Use in Association with Survival among Patients of Breast, Colorectal, Lung, or Gastric Cancer

Michelle L. Baglia, Yong Cui, Tao Zheng, Gong Yang, Honglan Li, Mingrong You, Liling Xu, Harvey Murff, Yu-Tang Gao, Wei Zheng, Yong-Bing Xiang, Xiao-Ou Shu

Cancer Res Treat. 2019;51(2):538-546. Published online July 2, 2018 DOI: https://doi.org/10.4143/crt.2017.591

547

Radiation Therapy Outcome and Clinical Features of Duodenal-Type Follicular Lymphoma

Hansang Lee, Dongryul Oh, Kyungmi Yang, Young Hyeh Ko, Yong Chan Ahn, Won Seog Kim, Seok Jin Kim

Cancer Res Treat. 2019;51(2):547-555. Published online July 10, 2018 DOI: https://doi.org/10.4143/crt.2018.190

556

Dong Wook Shin, Sang Hyub Lee, Tae-Hwan Kim, Seok Joong Yun, Jong Kil Nam, Seung Hyun Jeon, Seung Chol Park, Seung Il Jung, Jong-Hyock Park, Jinsung Park

Cancer Res Treat. 2019;51(2):556-567. Published online July 16, 2018 DOI: https://doi.org/10.4143/crt.2018.221

568

Verification of Low Risk for Perihippocampal Recurrence in Patients with Brain Metastases Who Received Whole-Brain Radiotherapy with Hippocampal Avoidance

Youngkyong Kim, Sung Hwan Kim, Jong Hoon Lee, Dae Gyu Kang

Cancer Res Treat. 2019;51(2):568-575. Published online July 16, 2018 DOI: https://doi.org/10.4143/crt.2018.206

576

Upregulation of PITX2 Promotes Letrozole Resistance Via Transcriptional Activation of IFITM1 Signaling in Breast Cancer Cells

Ying-ying Xu, Hai-ru Yu, Jia-yi Sun, Zhao Zhao, Shuang Li, Xin-feng Zhang, Zhi-xuan Liao, Ming-ke Cui, Juan Li, Chan Li, Qiang Zhang

Cancer Res Treat. 2019;51(2):576-592. Published online July 18, 2018 DOI: https://doi.org/10.4143/crt.2018.100

Cited By 1

593

Correlation of Androgen Deprivation Therapy with Cognitive Dysfunction in Patients with Prostate Cancer: A Nationwide Population-Based Study Using the National Health Insurance Service Database

Bum Sik Tae, Byung Jo Jeon, Seung Hun Shin, Hoon Choi, Jae Hyun Bae, Jae Young Park

Cancer Res Treat. 2019;51(2):593-602. Published online July 18, 2018 DOI: https://doi.org/10.4143/crt.2018.119

Cited By 3

603

Feasibility of Selective Neck Irradiation with Lower Elective Radiation Dose in Treating Nasopharynx Cancer Patients

Won Kyung Cho, Dongryul Oh, Eonju Lee, Tae Gyu Kim, Hyebin Lee, Heerim Nam, Jae Myoung Noh, Yong Chan Ahn

Cancer Res Treat. 2019;51(2):603-610. Published online July 18, 2018 DOI: https://doi.org/10.4143/crt.2018.240

611

Comparison of Efficacy of Pembrolizumab between Epstein-Barr Virus‒Positive and ‒Negative Relapsed or Refractory Non-Hodgkin Lymphomas

Seok-Jin Kim, Jiyeon Hyeon, Inju Cho, Young Hyeh Ko, Won Seog Kim

Cancer Res Treat. 2019;51(2):611-622. Published online July 20, 2018 DOI: https://doi.org/10.4143/crt.2018.191

623

Clinical Outcomes of EGFR Exon 20 Insertion Mutations in Advanced Non-small Cell Lung Cancer in Korea

Seonggyu Byeon, Youjin Kim, Sung Won Lim, Jang Ho Cho, Sehoon Park, Jiyun Lee, Jong-Mu Sun, Yoon-La Choi, Se-Hoon Lee, Jin Seok Ahn, Keunchil Park, Myung-Ju Ahn

Cancer Res Treat. 2019;51(2):623-631. Published online July 23, 2018 DOI: https://doi.org/10.4143/crt.2018.151

Cited By 1

632

Effect of Estradiol in an Azoxymethane/Dextran Sulfate Sodium-Treated Mouse Model of Colorectal Cancer: Implication for Sex Difference in Colorectal Cancer Development

Hee Jin Son, Sung Hwa Sohn, Nayoung Kim, Ha-Na Lee, Sun Min Lee, Ryoung Hee Nam, Ji Hyun Park, Chin-Hee Song, Eun Shin, Hee Young Na, Joo Sung Kim, Dong Ho Lee, Young-Joon Surh

Cancer Res Treat. 2019;51(2):632-648. Published online August 1, 2018 DOI: https://doi.org/10.4143/crt.2018.060

Cited By 1

649

Prognostic Role and Clinical Association of Tumor-Infiltrating Lymphocyte, Programmed Death Ligand-1 Expression with Neutrophil-Lymphocyte Ratio in Locally Advanced Triple-Negative Breast Cancer

Jieun Lee, Dong-Min Kim, Ahwon Lee

Cancer Res Treat. 2019;51(2):649-663. Published online July 31, 2018 DOI: https://doi.org/10.4143/crt.2018.270

664

Albumin-to-Fibrinogen Ratio as an Independent Prognostic Parameter in Untreated Chronic Lymphocytic Leukemia: A Retrospective Study of 191 Cases

Yi-Xin Zou, Jia Qiao, Hua-Yuan Zhu, Rui-Nan Lu, Yi Xia, Lei Cao, Wei Wu, Hui Jin, Wen-Jie Liu, Jin-Hua Liang, Jia-Zhu Wu, Li Wang, Lei Fan, Wei Xu, Jian-Yong Li

Cancer Res Treat. 2019;51(2):664-671. Published online August 1, 2018 DOI: https://doi.org/10.4143/crt.2018.358

672

Prediction of Acquired Taxane Resistance Using a Personalized Pathway-Based Machine Learning Method

Young Rae Kim, Dongha Kim, Sung Young Kim

Cancer Res Treat. 2019;51(2):672-684. Published online August 10, 2018 DOI: https://doi.org/10.4143/crt.2018.137

Cited By 1

685

Reduction of Target Volume and the Corresponding Dose for the Tumor Regression Field after Induction Chemotherapy in Locoregionally Advanced Nasopharyngeal Carcinoma

Lei Wang, Zheng Wu, Dehuan Xie, Ruifang Zeng, Wanqin Cheng, Jiang Hu, Shaomin Huang, Shu Zhou, Rui Zhong, Yong Su

Cancer Res Treat. 2019;51(2):685-695. Published online August 13, 2018 DOI: https://doi.org/10.4143/crt.2018.250

Cited By 1

696

Disulfiram, a Re-positioned Aldehyde Dehydrogenase Inhibitor, Enhances Radiosensitivity of Human Glioblastoma Cells In Vitro

Hyeon Kang Koh, Soo Yeon Seo, Jin Ho Kim, Hak Jae Kim, Eui Kyu Chie, Seung-Ki Kim, Il Han Kim

Cancer Res Treat. 2019;51(2):696-705. Published online August 13, 2018 DOI: https://doi.org/10.4143/crt.2018.249

706

The Clinical Value of PELP1 for Breast Cancer: A Comparison with Multiple Cancers and Analysis in Breast Cancer Subtypes

Xingen Wang, Julia Y. S. Tsang, Michelle A Lee, Yun-Bi Ni, Joanna H Tong, Siu-Ki Chan, Sai-Yin Cheung, Ka Fai To, Gary M Tse

Cancer Res Treat. 2019;51(2):706-717. Published online August 23, 2018 DOI: https://doi.org/10.4143/crt.2018.316

718

A Randomized, Open-Label, Phase II Study Comparing Pemetrexed Plus Cisplatin Followed by Maintenance Pemetrexed versus Pemetrexed Alone in Patients with Epidermal Growth Factor Receptor (EGFR)-Mutant Non-small Cell Lung Cancer after Failure of First-Line EGFR Tyrosine Kinase Inhibitor: KCSG-LU12-13

Kwai Han Yoo, Su Jin Lee, Jinhyun Cho, Ki Hyeong Lee, Keon Uk Park, Ki Hwan Kim, Eun Kyung Cho, Yoon Hee Choi, Hye Ryun Kim, Hoon-Gu Kim, Heui June Ahn, Ha Yeon Lee, Hwan Jung Yun, Jin-Hyoung Kang, Jaeheon Jeong, Moon Young Choi, Sin-Ho Jung, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Keunchil Park, Myung-Ju Ahn

Cancer Res Treat. 2019;51(2):718-726. Published online September 3, 2018 DOI: https://doi.org/10.4143/crt.2018.324

727

Early Decline in Left Ventricular Ejection Fraction Can Predict Trastuzumab-Related Cardiotoxicity in Patients with Breast Cancer: A Study Using 13 Years of Registry Data

Eun Kyoung Kim, Jinhyun Cho, Ji-Yeon Kim, Sung-A Chang, Sung-Ji Park, Jin Oh Choi, Sang Chol Lee, Jin Seok Ahn, Seung Woo Park, Young-Hyuck Im, Eun Seok Jeon, Yeon Hee Park

Cancer Res Treat. 2019;51(2):727-736. Published online September 4, 2018 DOI: https://doi.org/10.4143/crt.2018.262

Cited By 1

737

Discordance of the PAM50 Intrinsic Subtypes Compared with Immunohistochemistry-Based Surrogate in Breast Cancer Patients: Potential Implication of Genomic Alterations of Discordance

Hee Kyung Kim, Kyung Hee Park, Youjin Kim, Song Ee Park, Han Sang Lee, Sung Won Lim, Jang Ho Cho, Ji-Yeon Kim, Jeong Eon Lee, Jin Seok Ahn, Young-Hyuck Im, Jong Han Yu, Yeon Hee Park

Cancer Res Treat. 2019;51(2):737-747. Published online September 5, 2018 DOI: https://doi.org/10.4143/crt.2018.342

748

Genome-Wide Association of Genetic Variation in the PSCA Gene with Gastric Cancer Susceptibility in a Korean Population

Boyoung Park, Sarah Yang, Jeonghee Lee, Hae Dong Woo, Il Ju Choi, Young Woo Kim, Keun Won Ryu, Young-Il Kim, Jeongseon Kim

Cancer Res Treat. 2019;51(2):748-757. Published online September 5, 2018 DOI: https://doi.org/10.4143/crt.2018.162

758

Application of the International Metastatic Renal Cell Carcinoma Database Consortium and Memorial Sloan Kettering Cancer Center Risk Models in Patients with Metastatic Non-Clear Cell Renal Cell Carcinoma: A Multi-Institutional Retrospective Study Using the Korean Metastatic Renal Cell Carcinoma Registry

Jung Kwon Kim, Sung Han Kim, Mi Kyung Song, Jungnam Joo, Seong Il Seo, Cheol Kwak, Chang Wook Jeong, Cheryn Song, Eu Chang Hwang, Ill Young Seo, Hakmin Lee, Sung-Hoo Hong, Jae Young Park, Jinsoo Chung, Korean Renal Cell Carcinoma Study Group

Cancer Res Treat. 2019;51(2):758-768. Published online September 7, 2018 DOI: https://doi.org/10.4143/crt.2018.421

769

Salvage Concurrent Chemo-radiation Therapy for Loco-regional Recurrence Following Curative Surgery of Non-small Cell Lung Cancer

Kyung Hwa Lee, Yong Chan Ahn, Hongryull Pyo, Jae Myoung Noh, Seung Gyu Park, Tae Gyu Kim, Eonju Lee, Heerim Nam, Hyebin Lee, Jong-Mu Sun, Jin Seok Ahn, Myung-Ju Ahn, Keunchil Park

Cancer Res Treat. 2019;51(2):769-776. Published online September 11, 2018 DOI: https://doi.org/10.4143/crt.2018.366

777

A Phase II Trial of Osimertinib in the Second-Line Treatment of Non-small Cell Lung Cancer with the EGFR T790M Mutation, Detected from Circulating Tumor DNA: LiquidLung-O-Cohort 2

Cheol-Kyu Park, Hyun-Ju Cho, Yoo-Duk Choi, In-Jae Oh, Young-Chul Kim

Cancer Res Treat. 2019;51(2):777-787. Published online September 7, 2018 DOI: https://doi.org/10.4143/crt.2018.387

788

Comparative Effectiveness of Abdominal versus Laparoscopic Radical Hysterectomy for Cervical Cancer in the Postdissemination Era

Jin Hee Kim, Kyungjoo Kim, Seo Jin Park, Jung-Yun Lee, Kidong Kim, Myong Cheol Lim, Jae Weon Kim

Cancer Res Treat. 2019;51(2):788-796. Published online September 11, 2018 DOI: https://doi.org/10.4143/crt.2018.120

Cited By 3

797

A Potential Therapy Using Engineered Stem Cells Prevented Malignant Melanoma in Cellular and Xenograft Mouse Models

Jae-Rim Heo, Kyung-A Hwang, Seung U. Kim, Kyung-Chul Choi

Cancer Res Treat. 2019;51(2):797-811. Published online September 14, 2018 DOI: https://doi.org/10.4143/crt.2018.364

812

A Phase II Study to Evaluate the Safety and Efficacy of Pegteograstim in Korean Breast Cancer Patients Receiving Dose-Dense Doxorubicin/Cyclophosphamide

Gun Min Kim, Joo Hoon Kim, Ji Heung Kim, Young Up Cho, Seung Il Kim, Seho Park, Hyung Seok Park, Ji Ye Kim, Joohyuk Sohn

Cancer Res Treat. 2019;51(2):812-818. Published online September 19, 2018 DOI: https://doi.org/10.4143/crt.2018.383

819

Immunohistochemistry Biomarkers Predict Survival in Stage II/III Gastric Cancer Patients: From a Prospective Clinical Trial

Min Hwan Kim, Xianglan Zhang, Minkyu Jung, Inkyung Jung, Hyung Soon Park, Seung-Hoon Beom, Hyo Song Kim, Sun Young Rha, Hyunki Kim, Yoon Young Choi, Taeil Son, Hyoung-Il Kim, Jae-Ho Cheong, Woo Jin Hyung, Sung Hoon Noh, Hyun Cheol Chung

Cancer Res Treat. 2019;51(2):819-831. Published online September 27, 2018 DOI: https://doi.org/10.4143/crt.2018.331

832

Dynamics of Soluble Programmed Death-Ligand 1 (sPDL1) during Chemotherapy and Its Prognostic Implications in Cancer Patients: Biomarker Development in Immuno-oncology

Hyerim Ha, Ju-Hee Bang, Ah-Rong Nam, Ji-Eun Park, Mei Hua Jin, Yung-Jue Bang, Do-Youn Oh

Cancer Res Treat. 2019;51(2):832-840. Published online October 5, 2018 DOI: https://doi.org/10.4143/crt.2018.311