Cancer Research and Treatment

REVIEW ARTICLE 2023 March 15 Metastasis-Directed Local Therapy of Hepatic Oligometastasis from Colorectal Cancer and Future Perspective in Radiation Therapy
Introduction of the concept for oligometastasis led to wide application of metastasis-directed local ablative therapies for metastatic colorectal cancer (CRC). By application of the metastasis-directed local ablative therapies including surgical resection, radiofrequency ablatio...

REVIEW ARTICLE 2023 March 22 Cellular Dormancy in Cancer: Mechanisms and Potential Targeting Strategies
Cancer is a leading cause of disease-related mortality worldwide. Drug resistance is one of the primary reasons for the failure of anticancer therapy. There are a number of underlying mechanisms for anticancer drug resistance including genetic/epigenetic modifications, microenvi...

ORIGINAL ARTICLE 2023 January 4 Identification of Genes Involved in EGF-induced Apoptosis Using CRISPR/Cas9 Knockout Screening: Implications for Novel Therapeutic Targets in EGFR-Overexpressing Cancers
Purpose Exogenous epidermal growth factor (EGF) causes apoptosis in EGF receptor (EGFR)–overexpressing cell lines. The apoptosis-inducing factors could be a therapeutic target. We aimed to determine the mechanism of EGF-induced apoptosis using a genome-wide clustered regularly ...

ORIGINAL ARTICLE 2023 February 9 Immunogenicity and Safety of Vaccines against Coronavirus Disease in Actively Treated Patients with Solid Tumors: A Prospective Cohort Study
Purpose We aimed to assess the humoral response to and reactogenicity of coronavirus disease 2019 (COVID-19) vaccination according to the vaccine type and to analyze factors associated with immunogenicity in actively treated solid cancer patients (CPs). Materials and Methods Pr...

Current Issue

Volume 55(3); Jul 2023

Volume 55(2); April 2023

Volume 55(1); January 2023

Review Articles

707

Metastasis-Directed Local Therapy of Hepatic Oligometastasis from Colorectal Cancer and Future Perspective in Radiation Therapy

Gyu Sang Yoo, Chai Hong Rim, Won Kyung Cho, Jae-Uk Jeong, Eui Kyu Chie, Hyeon-Min Cho, Jun Won Um, Yong Chan Ahn, Jong Hoon Lee, on behalf of Korean Cancer Association Oligometastasis Working Group

Cancer Res Treat. 2023;55(3):707-719. Published online March 15, 2023 DOI: https://doi.org/10.4143/crt.2022.1599

720

Cellular Dormancy in Cancer: Mechanisms and Potential Targeting Strategies

Hye-Young Min, Ho-Young Lee

Cancer Res Treat. 2023;55(3):720-736. Published online March 22, 2023 DOI: https://doi.org/10.4143/crt.2023.468

Original Articles

General

737

Identification of Genes Involved in EGF-induced Apoptosis Using CRISPR/Cas9 Knockout Screening: Implications for Novel Therapeutic Targets in EGFR-Overexpressing Cancers

Jae Sik Kim, Joo Ho Lee, Sang-Rok Jeon, Yongsub Kim, Seung Hyuck Jeon, Hong-Gyun Wu

Cancer Res Treat. 2023;55(3):737-745. Published online January 4, 2023 DOI: https://doi.org/10.4143/crt.2022.1414

746

Immunogenicity and Safety of Vaccines against Coronavirus Disease in Actively Treated Patients with Solid Tumors: A Prospective Cohort Study

Yae Jee Baek, Youn-Jung Lee, So Ra Park, Kyoo Hyun Kim, Seung-Hoon Beom, Choong-kun Lee, Sang Joon Shin, Sun Young Rha, Sinyoung Kim, Kyoung Hwa Lee, Jung Ho Kim, Su Jin Jeong, Nam Su Ku, Jun Yong Choi, Joon-Sup Yeom, Minkyu Jung, Jin Young Ahn

Cancer Res Treat. 2023;55(3):746-757. Published online February 9, 2023 DOI: https://doi.org/10.4143/crt.2022.1541

Cited By 1

758

Recent Trends of Medical Expenses Associated with Radiation Therapy in Korea Based on HIRA Big Data

Jeong Eun Lee, Kyungmi Yang, Yong Chan Ahn, Won Park, Seung Jae Huh

Cancer Res Treat. 2023;55(3):758-765. Published online January 30, 2023 DOI: https://doi.org/10.4143/crt.2022.389

Breast cancer

766

Eflapegrastim versus Pegfilgrastim for Chemotherapy-Induced Neutropenia in Korean and Asian Patients with Early Breast Cancer: Results from the Two Phase III ADVANCE and RECOVER Studies

Yong Wha Moon, Seung Ki Kim, Keun Seok Lee, Moon Hee Lee, Yeon Hee Park, Kyong Hwa Park, Gun Min Kim, Seungtaek Lim, Seung Ah Lee, Jae Duk Choi, Eunhye Baek, Hyesun Han, Seungjae Baek, Seock-Ah Im

Cancer Res Treat. 2023;55(3):766-777. Published online January 19, 2023 DOI: https://doi.org/10.4143/crt.2022.987

Lung and Thoracic cancer

778

MLL4 Regulates the Progression of Non–Small-Cell Lung Cancer by Regulating the PI3K/AKT/SOX2 Axis

Yang Yang, Rongfang Qiu, Qiaoyou Weng, Ziwei Xu, Jingjing Song, Siyu Zhao, Miaomiao Meng, Dengke Zhang, Chunli Kong, Hailin Wang, Min Xu, Zhongwei Zhao, Jiansong Ji

Cancer Res Treat. 2023;55(3):778-803. Published online January 26, 2023 DOI: https://doi.org/10.4143/crt.2022.1042

804

The Incidence and Risk Factors of Chronic Pulmonary Infection after Radiotherapy in Patients with Lung Cancer

Yeonseok Choi, Jae Myoung Noh, Sun Hye Shin, Kyungjong Lee, Sang-Won Um, Hojoong Kim, Hongryull Pyo, Yong Chan Ahn, Byeong-Ho Jeong

Cancer Res Treat. 2023;55(3):804-813. Published online January 3, 2023 DOI: https://doi.org/10.4143/crt.2022.1305

814

Genomic Characteristics and the Potential Clinical Implications in Oligometastatic Non–Small Cell Lung Cancer

Rongxin Liao, Kehong Chen, Jinjin Li, Hengqiu He, Guangming Yi, Mingfeng Huang, Rongrong Chen, Lu Shen, Xiaoyue Zhang, Zaicheng Xu, Zhenzhou Yang, Yuan Peng

Cancer Res Treat. 2023;55(3):814-831. Published online January 12, 2023 DOI: https://doi.org/10.4143/crt.2022.1315

832

Diagnostic Performance of Endosonography to Detect Mediastinal Lymph Node Metastasis in Patients with Radiological N1 Non–Small Cell Lung Cancer

Bo-Guen Kim, Jong Ho Cho, Sun Hye Shin, Kyungjong Lee, Sang-Won Um, Hojoong Kim, Jhingook Kim, Young Mog Shim, Byeong-Ho Jeong

Cancer Res Treat. 2023;55(3):832-840. Published online March 2, 2023 DOI: https://doi.org/10.4143/crt.2022.1428

841

EGFR-TKI Combined with Pemetrexed versus EGFR-TKI Monotherapy in Advanced EGFR-Mutated NSCLC: A Prospective, Randomized, Exploratory Study

Weiguang Gu, Hua Zhang, Yiyu Lu, Minjing Li, Shuang Yang, Jianmiao Liang, Zhijian Ye, Zhihua Li, Minhong He, Xiaoliang Shi, Fei Wang, Dong You, Weiquan Gu, Weineng Feng

Cancer Res Treat. 2023;55(3):841-850. Published online February 13, 2023 DOI: https://doi.org/10.4143/crt.2022.1438

851

Combination of the LARS1 Inhibitor, BC-LI-0186 with a MEK1/2 Inhibitor Enhances the Anti-Tumor Effect in Non–Small Cell Lung Cancer

Sang Hoon Lee, Eun Young Kim, Jung Min Han, Gyoonhee Han, Yoon Soo Chang

Cancer Res Treat. 2023;55(3):851-864. Published online March 20, 2023 DOI: https://doi.org/10.4143/crt.2022.1527

865

Predictors of Post-chemoradiotherapy Pulmonary Complication in Locally Advanced Non–Small Cell Lung Cancer

Tae Hoon Lee, Byung-Hee Kang, Hak Jae Kim, Hong-Gyun Wu, Joo Ho Lee

Cancer Res Treat. 2023;55(3):865-874. Published online January 19, 2023 DOI: https://doi.org/10.4143/crt.2022.1538

875

Efficacy of Prophylactic Cranial Irradiation According to the Risk of Extracranial Recurrence in Limited-Stage Small Cell Lung Cancer

Tae Hoon Lee, Joo-Hyun Chung, Hong-Gyun Wu, Suzy Kim, Joo Ho Lee, Bhumsuk Keam, Jin-Soo Kim, Ki Hwan Kim, Byoung Hyuck Kim, Hak Jae Kim

Cancer Res Treat. 2023;55(3):875-884. Published online February 24, 2023 DOI: https://doi.org/10.4143/crt.2022.1583

885

A Randomized Phase II Study of Irinotecan Plus Cisplatin with or without Simvastatin in Ever-Smokers with Extended Disease Small Cell Lung Cancer

Youngjoo Lee, Soo-Hyun Lee, Geon Kook Lee, Eun Jin Lim, Ji-Youn Han

Cancer Res Treat. 2023;55(3):885-893. Published online March 20, 2023 DOI: https://doi.org/10.4143/crt.2023.283

Gastrointestinal cancer

894

Anti–PD-L1 Antibody and/or 17β-Estradiol Treatment Induces Changes in the Gut Microbiome in MC38 Colon Tumor Model

Chin-Hee Song, Nayoung Kim, Ryoung Hee Nam, Soo In Choi, Jae Young Jang, Jina Choi, Ha-Na Lee

Cancer Res Treat. 2023;55(3):894-909. Published online January 9, 2023 DOI: https://doi.org/10.4143/crt.2022.1427

Cited By 1

910

Overview of the National Cancer Screening Program for Colorectal Cancer in Korea over 14 Years (2004-2017)

Bomi Park, Eun Young Her, Kyeongmin Lee, Fatima Nari, Jae Kwan Jun, Kui Son Choi, Mina Suh

Cancer Res Treat. 2023;55(3):910-917. Published online March 8, 2023 DOI: https://doi.org/10.4143/crt.2022.1432

918

One-Week versus Two-Week Chemoradiotherapy Followed by Curative Surgery in Rectal Cancer: Long-Term Comparative Pooled Analysis of Two Prospective Multicenter Phase II Trials

Soo-Yoon Sung, Dae Yong Kim, Hong Seok Jang, Tae Hyun Kim, Hee Chul Park, Eui Kyu Chie, Taek-Keun Nam, Sung Hwan Kim, Jong Hoon Lee

Cancer Res Treat. 2023;55(3):918-926. Published online February 27, 2023 DOI: https://doi.org/10.4143/crt.2022.1646

927

Circulating Tumor DNA Dynamics and Treatment Outcome of Regorafenib in Metastatic Colorectal Cancer

Dae-Won Lee, Yoojoo Lim, Hwang-Phill Kim, Su Yeon Kim, Hanseong Roh, Jun-Kyu Kang, Kyung‑Hun Lee, Min Jung Kim, Seung-Bum Ryoo, Ji Won Park, Seung-Yong Jeong, Kyu Joo Park, Gyeong Hoon Kang, Sae-Won Han, Tae-You Kim

Cancer Res Treat. 2023;55(3):927-938. Published online March 7, 2023 DOI: https://doi.org/10.4143/crt.2023.268

Cited By 1

939

Intraindividual Comparison of MRIs with Extracellular and Hepatobiliary Contrast Agents for the Noninvasive Diagnosis of Hepatocellular Carcinoma Using the Korean Liver Cancer Association–National Cancer Center 2022 Criteria

Ja Kyung Yoon, Dai Hoon Han, Sunyoung Lee, Jin-Young Choi, Gi Hong Choi, Do Young Kim, Myeong-Jin Kim

Cancer Res Treat. 2023;55(3):939-947. Published online February 10, 2023 DOI: https://doi.org/10.4143/crt.2022.1645

948

The Oncologic Implications of Tumor Multiplicity in Intrahepatic Cholangiocarcinoma: Its Prognostic Value Might Be Underestimated

So Jeong Yoon, Sunghae Park, Hongbeom Kim, Sang Hyun Shin, Jin Seok Heo, Jinsoo Rhu, Gyu-Seong Choi, Jong Man Kim, Jae-Won Joh, In Woong Han

Cancer Res Treat. 2023;55(3):948-955. Published online February 27, 2023 DOI: https://doi.org/10.4143/crt.2023.290

956

Survival Benefit of Adjuvant Chemotherapy in Patients with Pancreatic Ductal Adenocarcinoma Who Underwent Surgery Following Neoadjuvant FOLFIRINOX

So Heun Lee, Dae Wook Hwang, Changhoon Yoo, Kyu-pyo Kim, Sora Kang, Jae Ho Jeong, Dongwook Oh, Tae Jun Song, Sang Soo Lee, Do Hyun Park, Dong Wan Seo, Jin-hong Park, Ki Byung Song, Jae Hoon Lee, Woohyung Lee, Yejong Park, Bong Jun Kwak, Heung-Moon Chang, Baek-Yeol Ryoo, Song Cheol Kim

Cancer Res Treat. 2023;55(3):956-968. Published online February 27, 2023 DOI: https://doi.org/10.4143/crt.2022.409

Genitourinary cancer

969

Early Plasma Circulating Tumor DNA as a Potential Biomarker of Disease Recurrence in Non-metastatic Prostate Cancer

Xiaochen Fei, Xinxing Du, Yiming Gong, Jiazhou Liu, Liancheng Fan, Jiayi Wang, Yanqing Wang, Yinjie Zhu, Jiahua Pan, Baijun Dong, Wei Xue

Cancer Res Treat. 2023;55(3):969-977. Published online March 2, 2023 DOI: https://doi.org/10.4143/crt.2022.1557

Gynecologic cancer

978

Genomic and Transcriptomic Characterization Revealed the High Sensitivity of Targeted Therapy and Immunotherapy in a Subset of Endometrial Stromal Sarcoma

Nan Kang, Yinli Zhang, Shichao Guo, Ran Chen, Fangzhou Kong, Shuchun Wang, Mingming Yuan, Rongrong Chen, Danhua Shen, Jianliu Wang

Cancer Res Treat. 2023;55(3):978-991. Published online February 2, 2023 DOI: https://doi.org/10.4143/crt.2022.1647

Pediatric cancer

992

Gonadal Function in Female Adolescent and Young Adult Survivors of Childhood Cancer

Hye Young Jin, Jun Ah Lee, Meerim Park, Hyeon Jin Park

Cancer Res Treat. 2023;55(3):992-1000. Published online January 31, 2023 DOI: https://doi.org/10.4143/crt.2022.1518

Sarcoma

1001

Clinicopathological Analysis and Treatment of Adult Patients with Inflammatory Myofibroblastic Tumor: A 15-Year Single-Center Study

Xin Liu, Chengcheng Gong, Jieyun Zhang, Wanjing Feng, Yanjing Guo, Youzhou Sang, Chunmeng Wang, Yong Chen, Jian Wang, Lin Yu, Xiaowei Zhang, Zhiguo Luo

Cancer Res Treat. 2023;55(3):1001-1010. Published online March 3, 2023 DOI: https://doi.org/10.4143/crt.2022.894

Hematologic malignancy

1011

Clinical Significance of bZIP In-Frame CEBPA-Mutated Normal Karyotype Acute Myeloid Leukemia

Seo-Yeon Ahn, TaeHyung Kim, Mihee Kim, Ga-Young Song, Sung-Hoon Jung, Deok-Hwan Yang, Je-Jung Lee, Mi Yeon Kim, Chul Won Jung, Jun-Ho Jang, Hee Je Kim, Joon Ho Moon, Sang Kyun Sohn, Jong-Ho Won, Sung-Hyun Kim, Hyeoung-Joon Kim, Jae-Sook Ahn, Dennis Dong Hwan Kim

Cancer Res Treat. 2023;55(3):1011-1022. Published online January 26, 2023 DOI: https://doi.org/10.4143/crt.2022.1407

1023

Clinical Impact of Drug Adherence of Tyrosine Kinase Inhibitors in Children with Ph-Positive Acute Lymphoblastic Leukemia

Jun-Xia Wang, Miao-Miao Yang, Li-Peng Liu, Hui-Min Zhang, Meng-Chuan Wang, Yu-Wen Chen, Xiao-Ying Zang, Fang Hu

Cancer Res Treat. 2023;55(3):1023-1030. Published online February 6, 2023 DOI: https://doi.org/10.4143/crt.2022.1618

1031

Efficacy of Salvage Treatments in Relapsed or Refractory Diffuse Large B-Cell Lymphoma Including Chimeric Antigen Receptor T-Cell Therapy: A Systematic Review and Meta-Analysis

Jinchul Kim, Jinhyun Cho, Sang Eun Yoon, Won Seog Kim, Seok Jin Kim

Cancer Res Treat. 2023;55(3):1031-1047. Published online March 13, 2023 DOI: https://doi.org/10.4143/crt.2022.1658

Case Reports

1048

Efficacy of Olaparib in Treatment-Refractory, Metastatic Breast Cancer with Uncommon Somatic BRCA Mutations Detected in Circulating Tumor DNA

Jung-Ki Yoon, Jongseong Ahn, Sheehyun Kim, Hwang-Phil Kim, Jun-kyu Kang, Duhee Bang, Yoojoo Lim, Tae-You Kim

Cancer Res Treat. 2023;55(3):1048-1052. Published online January 31, 2023 DOI: https://doi.org/10.4143/crt.2022.1529

Cited By 1

1053

Case Report of Erdheim-Chester Disease Successfully Treated with Pegylated Interferon: A Single-Center Experience

Yujin Lim, Sang Eun Yoon, Junhun Cho, Darae Kim, Chul Won Jung

Cancer Res Treat. 2023;55(3):1053-1057. Published online January 19, 2023 DOI: https://doi.org/10.4143/crt.2022.1535

Correspondence

1058

Right Then, Wrong Now: Early-Onset Colorectal Cancer in Korea

Aesun Shin, Kyu-Won Jung, Seung-Yong Jeong

Cancer Res Treat. 2023;55(3):1058-1060. Published online February 6, 2023 DOI: https://doi.org/10.4143/crt.2022.1612

Cited By 1

Erratum

1061

ERRATUM: Recommendations for the Use of Next-Generation Sequencing and the Molecular Tumor Board for Patients with Advanced Cancer: A Report from KSMO and KCSG Precision Medicine Networking Group [Original]

Shinkyo Yoon, Miso Kim, Yong Sang Hong, Han Sang Kim, Seung Tae Kim, Jihun Kim, Hongseok Yun, Changhoon Yoo, Hee Kyung Ahn, Hyo Song Kim, In Hee Lee, In-Ho Kim, Inkeun Park, Jae Ho Jeong, Jaekyung Cheon, Jin Won Kim, Jina Yun, Sun Min Lim, Yongjun Cha, Se Jin Jang, Dae Young Zang, Tae Won Kim, Jin Hyoung Kang, Jee Hyun Kim

Cancer Res Treat. 2023;55(3):1061-1061. Published online April 21, 2023 DOI: https://doi.org/10.4143/crt.2021.1115.E