Cancer Research and Treatment

SPECIAL ARTICLE 2020 June 2 Choosing Wisely: The Korean Perspective and Launch of the ‘Right Decision in Cancer Care’ Initiative
Government healthcare expenditure is rising in Korea, and the costs incurred by patients in Korea exceed those incurred by patients in other Organization for Economic Co-operation and Development countries. Despite the increasing health expenditure, patient demand for services i...

ORIGINAL ARTICLE 2020 January 10 PD-L1 Testing in Gastric Cancer by the Combined Positive Score of the 22C3 PharmDx and SP263 Assay with Clinically Relevant Cut-offs
Purpose We provide a comparison between 22C3 pharmDx and SP263 assay, for evaluating programmed death ligand 1 (PD-L1) expression in advanced gastric cancer (GC) patients. Materials and Methods The PD-L1 immunohistochemistry by 22C3 pharmDx and SP263 assays was performed in...

ORIGINAL ARTICLE 2020 January 28 Comparison of the Distribution Pattern of 21-Gene Recurrence Score between Mucinous Breast Cancer and Infiltrating Ductal Carcinoma in Chinese Population: A Retrospective Single-Center Study
Purpose This retrospective study aimed to evaluate the distribution pattern and prognostic value of 21-gene recurrence score (RS) in Chinese patients with mucinous breast cancer (MC) and compared with infiltrating ductal carcinoma (IDC). Materials and Methods Patients diagnos...

ORIGINAL ARTICLE 2020 January 28 Clinicopathological Features of Patients with the BRCA1 c.5339T>C (p.Leu1780Pro) Variant
Purpose Recent studies revealed the BRCA1 c.5339T>C, p.Leu1780Pro variant (L1780P) is highly suggested as a likely pathogenic. The aim of this study was to evaluate clinicopathologic features of L1780P with breast cancer (BC) using multicenter data from Korea to reinforce the e...

Current Issue

Volume 52(3); Jul 2020

Volume 52(2); April 2020

Volume 52(1); January 2020

Special Article

655

Choosing Wisely: The Korean Perspective and Launch of the ‘Right Decision in Cancer Care’ Initiative

Joo-Young Kim, Kyoung Eun Lee, Kyubo Kim, Myung Ah Lee, Won Sup Yoon, Dong Seok Han, Sung Gwe Ahn, Jung-Hun Kang

Cancer Res Treat. 2020;52(3):655-660. Published online June 2, 2020 DOI: https://doi.org/10.4143/crt.2020.221

Original Articles

661

PD-L1 Testing in Gastric Cancer by the Combined Positive Score of the 22C3 PharmDx and SP263 Assay with Clinically Relevant Cut-offs

Yujun Park, Jiwon Koh, Hee Young Na, Yoonjin Kwak, Keun-Wook Lee, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim, Hye Seung Lee

Cancer Res Treat. 2020;52(3):661-670. Published online January 10, 2020 DOI: https://doi.org/10.4143/crt.2019.718

Cited By 1

671

Comparison of the Distribution Pattern of 21-Gene Recurrence Score between Mucinous Breast Cancer and Infiltrating Ductal Carcinoma in Chinese Population: A Retrospective Single-Center Study

Jiayi Wu, Shuning Ding, Lin Lin, Xiaochun Fei, Caijin Lin, Lisa Andriani, Chihwan Goh, Jiahui Huang, Jin Hong, Weiqi Gao, Siji Zhu, Hui Wang, Ou Huang, Xiaosong Chen, Jianrong He, Yafen Li, Kunwei Shen, Weiguo Chen, Li Zhu

Cancer Res Treat. 2020;52(3):671-679. Published online January 28, 2020 DOI: https://doi.org/10.4143/crt.2019.387

680

Clinicopathological Features of Patients with the BRCA1 c.5339T>C (p.Leu1780Pro) Variant

Hyung Seok Park, Jai Min Ryu, Ji Soo Park, Seock-Ah Im, So-Youn Jung, Eun-Kyu Kim, Woo-Chan Park, Jun Won Min, Jeeyeon Lee, Ji Young You, Jeong Eon Lee, Sung-Won Kim

Cancer Res Treat. 2020;52(3):680-688. Published online January 28, 2020 DOI: https://doi.org/10.4143/crt.2019.351

689

PIK3CA H1047R Mutation Associated with a Lower Pathological Complete Response Rate in Triple-Negative Breast Cancer Patients Treated with Anthracycline-Taxane–Based Neoadjuvant Chemotherapy

Sanxing Guo, Sibylle Loibl, Gunter von Minckwitz, Silvia Darb-Esfahani, Bianca Lederer, Carsten Denkert

Cancer Res Treat. 2020;52(3):689-696. Published online February 4, 2020 DOI: https://doi.org/10.4143/crt.2019.497

Cited By 1

697

Detection of Germline Mutations in Breast Cancer Patients with Clinical Features of Hereditary Cancer Syndrome Using a Multi-Gene Panel Test

Hee-Chul Shin, Han-Byoel Lee, Tae-Kyung Yoo, Eun-Shin Lee, Ryong Nam Kim, Boyoung Park, Kyong-Ah Yoon, Charny Park, Eun Sook Lee, Hyeong-Gon Moon, Dong-Young Noh, Sun-Young Kong, Wonshik Han

Cancer Res Treat. 2020;52(3):697-713. Published online February 4, 2020 DOI: https://doi.org/10.4143/crt.2019.559

Cited By 2

714

Diagnostic Accuracy and Value of Magnetic Resonance Imaging–Ultrasound Fusion Transperineal Targeted and Template Systematic Prostate Biopsy Based on Bi-parametric Magnetic Resonance Imaging

Tae Il Noh, Jong Hyun Tae, Hyung Keun Kim, Ji Sung Shim, Sung Gu Kang, Deuk Jae Sung, Jun Cheon, Jeong Gu Lee, Seok Ho Kang

Cancer Res Treat. 2020;52(3):714-721. Published online February 10, 2020 DOI: https://doi.org/10.4143/crt.2019.716

722

Public Attitudes towards Cancer Survivors among Korean Adults

Su Yeon Kye, Hyun Jeong Lee, Yeonseung Lee, Young Ae Kim

Cancer Res Treat. 2020;52(3):722-729. Published online February 6, 2020 DOI: https://doi.org/10.4143/crt.2019.265

730

Clinical Outcomes of Immune Checkpoint Blocker Therapy for Malignant Melanoma in Korean Patients: Potential Clinical Implications for a Combination Strategy Involving Radiotherapy

Jeongshim Lee, Jee Suk Chang, Mi Ryung Roh, Minkyu Jung, Choong-Kun Lee, Byung Ho Oh, Kee Yang Chung, Woong Sub Koom, Sang Joon Shin

Cancer Res Treat. 2020;52(3):730-738. Published online February 13, 2020 DOI: https://doi.org/10.4143/crt.2019.598

739

Comparing the Characteristics and Outcomes of Male and Female Breast Cancer Patients in Korea: Korea Central Cancer Registry

Eun-Gyeong Lee, So-Youn Jung, Myong Cheol Lim, Jiwon Lim, Han-Sung Kang, Seeyoun Lee, Jai Hong Han, Heein Jo, Young-Joo Won, Eun Sook Lee

Cancer Res Treat. 2020;52(3):739-746. Published online February 13, 2020 DOI: https://doi.org/10.4143/crt.2019.639

Cited By 1

747

T Cells Modified with CD70 as an Alternative Cellular Vaccine for Antitumor Immunity

Sang-Eun Lee, A-Ri Shin, Hyun-Jung Sohn, Hyun-Il Cho, Tai-Gyu Kim

Cancer Res Treat. 2020;52(3):747-763. Published online February 14, 2020 DOI: https://doi.org/10.4143/crt.2019.721

764

Clinical Implication of Concordant or Discordant Genomic Profiling between Primary and Matched Metastatic Tissues in Patients with Colorectal Cancer

Jung Yoon Choi, Sunho Choi, Minhyeok Lee, Young Soo Park, Jae Sook Sung, Won Jin Chang, Ju Won Kim, Yoon Ji Choi, Jin Kim, Dong-Sik Kim, Sung-Ho Lee, Junhee Seok, Kyong Hwa Park, Seon Hahn Kim, Yeul Hong Kim

Cancer Res Treat. 2020;52(3):764-778. Published online February 16, 2020 DOI: https://doi.org/10.4143/crt.2020.044

779

Clinical Implications of Circulating Tumor DNA from Ascites and Serial Plasma in Ovarian Cancer

Mi-Ryung Han, Sug Hyung Lee, Jung Yoon Park, Hyosun Hong, Jung Yoon Ho, Soo Young Hur, Youn Jin Choi

Cancer Res Treat. 2020;52(3):779-788. Published online February 28, 2020 DOI: https://doi.org/10.4143/crt.2019.700

789

Soluble Axl Is a Novel Diagnostic Biomarker of Hepatocellular Carcinoma in Chinese Patients with Chronic Hepatitis B Virus Infection

Xiaoting Song, Ailu Wu, Zhixiao Ding, Shixiong Liang, Chunyan Zhang

Cancer Res Treat. 2020;52(3):789-797. Published online March 5, 2020 DOI: https://doi.org/10.4143/crt.2019.749

Cited By 1

798

Long Non-coding RNA CCAT1 Sponges miR-454 to Promote Chemoresistance of Ovarian Cancer Cells to Cisplatin by Regulation of Surviving

De-Ying Wang, Na Li, Yu-Lan Cui

Cancer Res Treat. 2020;52(3):798-814. Published online March 3, 2020 DOI: https://doi.org/10.4143/crt.2019.498

Cited By 5

815

G Protein–Coupled Receptor 30 Mediates the Anticancer Effects Induced by Eicosapentaenoic Acid in Ovarian Cancer Cells

Yue Zhao, Meng-Fei Zhao, Mei-Lin Yang, Tian-Yu Wu, Cong-Jian Xu, Jing-Mei Wang, Chao-Jun Li, Xi Li

Cancer Res Treat. 2020;52(3):815-829. Published online March 5, 2020 DOI: https://doi.org/10.4143/crt.2019.380

830

Activation of β₂-Adrenergic Receptor Promotes Growth and Angiogenesis in Breast Cancer by Down-regulating PPARγ

Jing Zhou, Zhanzhao Liu, Lingjing Zhang, Xiao Hu, Zhihua Wang, Hong Ni, Yue Wang, Junfang Qin

Cancer Res Treat. 2020;52(3):830-847. Published online March 4, 2020 DOI: https://doi.org/10.4143/crt.2019.510

Cited By 1

848

Omega-3 and -6 Fatty Acid Intake and Colorectal Cancer Risk in Swedish Women’s Lifestyle and Health Cohort

Aesun Shin, Sooyoung Cho, Sven Sandin, Marie Lof, Moon Young Oh, Elisabete Weiderpass

Cancer Res Treat. 2020;52(3):848-854. Published online March 6, 2020 DOI: https://doi.org/10.4143/crt.2019.550

Cited By 3

855

Establishment and Validation of a Nomogram for Nasopharyngeal Carcinoma Patients Concerning the Prognostic Effect of Parotid Lymph Node Metastases

Chao Lin, Xue-Song Sun, Sai-Lan Liu, Xiao-Yun Li, Nian Lu, Xin-Ling Li, Lin-Quan Tang, Ling Guo

Cancer Res Treat. 2020;52(3):855-866. Published online March 10, 2020 DOI: https://doi.org/10.4143/crt.2019.772

Cited By 2

867

Caspase Recruitment Domain Containing Protein 9 Suppresses Non-Small Cell Lung Cancer Proliferation and Invasion via Inhibiting MAPK/p38 Pathway

Linyue Pan, Yuting Tan, Bin Wang, Wenjia Qiu, Yulei Yin, Haiyan Ge, Huili Zhu

Cancer Res Treat. 2020;52(3):867-885. Published online March 11, 2020 DOI: https://doi.org/10.4143/crt.2019.606

886

Prognostic Predictability of American Joint Committee on Cancer 8th Staging System for Perihilar Cholangiocarcinoma: Limited Improvement Compared with the 7th Staging System

Jong Woo Lee, Jae Hoon Lee, Yejong Park, Woohyung Lee, Jaewoo Kwon, Ki Byung Song, Dae Wook Hwang, Song Cheol Kim

Cancer Res Treat. 2020;52(3):886-895. Published online March 12, 2020 DOI: https://doi.org/10.4143/crt.2020.023

896

Socioeconomic Burden of Cancer in Korea from 2011 to 2015

Young Ae Kim, Ye-Rin Lee, Jeongjoo Park, In-Hwan Oh, Hoseob Kim, Seok-Jun Yoon, Keeho Park

Cancer Res Treat. 2020;52(3):896-906. Published online March 18, 2020 DOI: https://doi.org/10.4143/crt.2019.398

Cited By 1

907

Ramosetron versus Palonosetron in Combination with Aprepitant and Dexamethasone for the Control of Highly-Emetogenic Chemotherapy-Induced Nausea and Vomiting

Jin Hyoung Kang, Jung Hye Kwon, Yun-Gyoo Lee, Keon Uk Park, Ho Jung An, Joohyuk Sohn, Young Mi Seol, Hyunwoo Lee, Hwan-Jung Yun, Jin Seok Ahn, Ji Hyun Yang, Hunho Song, Dong-Hoe Koo, Jin Young Kim, Gun Min Kim, Hwa Jung Kim

Cancer Res Treat. 2020;52(3):907-916. Published online March 18, 2020 DOI: https://doi.org/10.4143/crt.2019.713

Cited By 1

917

Implication of the Life-Sustaining Treatment Decisions Act on End-of-Life Care for Korean Terminal Patients

Jung Sun Kim, Shin Hye Yoo, Wonho Choi, Yejin Kim, Jinui Hong, Min Sun Kim, Hye Yoon Park, Bhumsuk Keam, Dae Seog Heo

Cancer Res Treat. 2020;52(3):917-924. Published online March 23, 2020 DOI: https://doi.org/10.4143/crt.2019.740

925

Prognostic Value of TP53 Mutation for Transcatheter Arterial Chemoembolization Failure/Refractoriness in HBV-Related Advanced Hepatocellular Carcinoma

Miao Xue, Yanqin Wu, Wenzhe Fan, Jian Guo, Jialiang Wei, Hongyu Wang, Jizhou Tan, Yu Wang, Wang Yao, Yue Zhao, Jiaping Li

Cancer Res Treat. 2020;52(3):925-937. Published online March 30, 2020 DOI: https://doi.org/10.4143/crt.2019.533

938

Laparoscopic Surgery for Colorectal Cancer in Korea: Nationwide Data from 2013 to 2018

Sun Jin Park, Kil Yeon Lee, Suk-Hwan Lee

Cancer Res Treat. 2020;52(3):938-944. Published online April 6, 2020 DOI: https://doi.org/10.4143/crt.2020.043

945

Inhibition of ATR Increases the Sensitivity to WEE1 Inhibitor in Biliary Tract Cancer

Ah-Rong Nam, Mei-Hua Jin, Ju-Hee Bang, Kyoung-Seok Oh, Hye-Rim Seo, Do-Youn Oh, Yung-Jue Bang

Cancer Res Treat. 2020;52(3):945-956. Published online April 17, 2020 DOI: https://doi.org/10.4143/crt.2020.080

957

Computed Tomography–Determined Sarcopenia Is a Useful Imaging Biomarker for Predicting Postoperative Outcomes in Elderly Colorectal Cancer Patients

Hailun Xie, Yizhen Gong, Jiaan Kuang, Ling Yan, Guotian Ruan, Shuangyi Tang, Feng Gao, Jialiang Gan

Cancer Res Treat. 2020;52(3):957-972. Published online April 17, 2020 DOI: https://doi.org/10.4143/crt.2019.695

973

RON and MET Co-overexpression Are Significant Pathological Characteristics of Poor Survival and Therapeutic Targets of Tyrosine Kinase Inhibitors in Triple-Negative Breast Cancer

Tian-Hao Weng, Min-Ya Yao, Xiang-Ming Xu, Chen-Yu Hu, Shu-Hao Yao, Yi-Zhi Liu, Zhi-Gang Wu, Tao-Ming Tang, Pei-Fen Fu, Ming-Hai Wang, Hang-Ping Yao

Cancer Res Treat. 2020;52(3):973-986. Published online April 22, 2020 DOI: https://doi.org/10.4143/crt.2019.726

Cited By 1

Case Report

987

Philadelphia+ Chronic Myeloid Leukemia with CALR Mutation: A Case Report and Literature Review

Seug Yun Yoon, Sun Young Jeong, Changgon Kim, Min-Young Lee, Jieun Kim, Kyoung-Ha Kim, Namsu Lee, Jong-Ho Won

Cancer Res Treat. 2020;52(3):987-991. Published online January 15, 2020 DOI: https://doi.org/10.4143/crt.2019.703