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Cancer Research and Treatment > Accepted Articles
doi: https://doi.org/10.4143/crt.2023.539    [Accepted]
Association between Metabolically Healthy Status and Risk of Gastrointestinal Cancer
Haozhe Cui1,2 , Fei Tian3, Yongliang Chen1,4 , Xiangming Ma2
1School of Medicine, Nankai University, Tianjin, China
2Department of Hepatobiliary Surgery, Kailuan General Hospital, Tangshan, China
3Department of Radiation Oncology, North China University of Science and Technology Affiliated Hospital, Tangshan, China
4The Faculty of Hepatopancreatobiliary Surgery, The First Medical Center, Chinese People’s Liberation Army General Hospital, Beijing, China
Correspondence  Yongliang Chen ,Tel: 86-0315-3025653, Fax: 86-0315-3025653, Email: chenyongliang153@163.com
Xiangming Ma ,Tel: 86-010-66875532, Fax: 86-010-66875532, Email: brighter_ma@163.com
Received: April 3, 2023;  Accepted: July 28, 2023.  Published online: August 2, 2023.
Although obesity is associated with numerous diseases, the risks of disease may depend on metabolically healthy status. Nevertheless, it is unclear to whether metabolically healthy status affects risk of gastrointestinal (GI) cancer in general Chinese population.
Materials and Methods
A total of 114,995 participants who met the criteria were included from the Kailuan Study. The study participants were divided into 4 groups according to BMI/WC and metabolic status. Incident of GI cancer (esophageal cancer, gastric cancer, liver cancer, biliary cancer, pancreatic cancer and colorectal cancer) during 2006-2020 were confirmed by review of medical records. The Cox proportional hazard regression models were used to assess the association metabolically healthy status with the risk of GI cancer by calculating the hazard ratios (HR) and 95% confidence interval (CI).
During a mean 13.76 years of follow-up, we documented 2,311 GI cancers. Multivariate Cox regression analysis showed that compared with the MHNW group, MHO participants demonstrated an increased risk of developing GI cancer(HR 1.54, 95%CI 1.11-2.13) by BMI categories. However, such associations were not found for WC category. These associations were moderated by age, gender and anatomical site of the tumor. Individuals with MUNW or MUO phenotype also have an increased risk of GI cancer.
MHO phenotype was associated with increased risk of GI cancer. Moreover, individuals who complicated by metabolic unhealthy status have an increased risk of developing GI cancer. Hence, clinicians should consider the risk of incident GI cancer in people with abnormal metabolically healthy status and counsel them about metabolic fitness and weight control.
Key words: Metabolically healthy status, Gastrointestinal Neoplasms, Cohort Studies, Risk Factors
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