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J Korean Cancer Assoc > Volume 28(6); 1996 > Article
Journal of the Korean Cancer Association 1996;28(6): 1010-1021.
유방암에서 호르몬 수용체와 nm23 단백 발현에 관한 연구
정기훈, 이은숙, 최원준, 배정원, 김영철, 구범환, 김철환, 김인선
Significance of Hormaone Receptors and nm23 Protein Expression in Human Breast Cancer
Ki Hoon Jung, Eun Sook Lee, Won Jun Choi, Jeoung Won Bae, Young Chul Kim, Bum Hwan Koo, Chul Hwan Kim, In Sun Kim
ABSTRACT
The nm23 gene was originally identified by differential hybridization between two murine melanoma cell sublines which have low and high metastatic potential, and located in the chromosome 17q22. This gene has known to be involved in metastasis of several cancers and its down-regulation usually associated with metastasis or disease progression in breast cancer. This study was designed to determine the significance of overexpression of the entimetastatic gene nm23 protein in human breast cancer and to compare it with established clinicopatholoaical prognostic factors such as the tumor size, number of involved lymph nodes, grade of differentiation, and hormone receptor status. 118 surgical specimens, which were obtained from breast cancer between July of 1989 and June of 1993 were used to evaluate nm23 protein expression using immunohistochemical staining. All patients were female. The nm23 protein expression was positive in 74 cases(63%) and was negative in 44 cases(37%). There was a significant inverse relationship between nm23 pratein overexpression and Bloom and Richardson histologic grade(p=0.023). Also overexpression of nm23 was significantly correlated with estrogen and progesterone receptor(p=0.031, 0.001) and with longer disease free survival and overall survival(p=0.0048, 0.0026). In conclusion, nm23 protein overexpression is one of good prognostic indicators independently in human breast cancer.
Key words: Breast cancer, Hormone receptors, nm23 protein
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