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J Korean Cancer Assoc > Volume 28(3); 1996 > Article
Journal of the Korean Cancer Association 1996;28(3): 427-432.
인체 위 선암 조직에서 p53 단백질 발현이 예후에 미치는 영향
이한일, 허영수, 유완식, 김익수
The Prognostic Significance of the p53 Protein Expression in Gastric Carcinoma
Han Il Lee, Young Soo Huh, Wan Sik Yu, Ik Soo Kim
ABSTRACT
p53 expressian in formalin-fixed paraffin-embedded samples of 55 patients with gastric carcinoma, who underwent gastrectomy, was analyzed immunohistochemically with DO-7, a monoclonal antibody. In 21 of 55 tumors (38.2%), nuclear immunoreactivity for the p53 protein was detected. There was no correlation with depth of tumor invasion, lymph node metastasis, distant metastasis, stage of cancer or histologic type. p53 expression was not correlated with prognosis in survival analysis. These results showed that the p53 protein expression can not be used as a prognostic indicator in gastric carcinoma.
Key words: Gastric cancer, Immunohistochemistry
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