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J Korean Cancer Assoc > Volume 28(1); 1996 > Article
Journal of the Korean Cancer Association 1996;28(1): 43-50.
듀스크병기 B 대장암 환자에서 림프절 미소전이가 예후에 미치는 영향
이관식, 황일우, 박매자, 김익수, 서인수, 전수한
Lymph Node Micrometastases from Dukes'B Colorectal Cacner : Immunohistochemical detection , and prognostic significance
Kwan Sik Lee, Il Woo Whang, Mae Ja Park, Ik Soo Kim, In Soo Suh, Soo Han Jun
This study was performed to identify micrometastases in lymph nodes from colorectal cancer considered free of disease by the routine hematoxylin-eosin stain, using immunohistochemistry according to ABC method. All 993 lymph nodes from 56 patients with Dukes'B colorectal cancer were stained retrospectively with antibody against cytokeratin(antikeratin AEl/AE3, Boeringer Mannheim). Single tumor cells and small clusters of tumor cells were detected in nodes of 20 patients(35.7%), mainly in the subcapsular sinuses. Twenty nine of the 36 patients with cytokeratin-negative lymph nodes lived after a mean followup of 55 months. But, 8 of the 20 patients with cytokeratin-positive lymph nodes lived over the same time period. Multivariate analyses were performed with several prognostic factors: age, histologic differentiation, vascular and lymphatic invasion, and presence of micrometastases. The most significant factor for both survival and recurrence was the presence of micrometastases(P= 0.0403 and P=0.0364 respectively). The presence of cytokeratin-positive cells within lymph nodes of Dukes'B colorectal cancer correlated with a poor prognosis.
Key words: Micrometastases, Lymph node, Colorectal cancer
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