Abstract

A very rare spontaneous transplantable salivary adenocarcimoma wss found four years ago in the right submaxillary region of a untreated male albino moase bred in Seoul area. At autopsy, tumor, 2. 0 cm. in greatest diameter, was nodular, whitish-pink- and noneneapsulated, and proved to be arisen from salivary gland. Microscopically, the tumor was of a relatively well differentiated adenocarcinoma with extensive necrosis. Thegrowth was composed of acini, cords and sheets of cells supported by thin strands of fibrous stroma. Transplantabilities to mice were 13.5% in the original albino strain, 0% in DBA/2N, 6.8% in C3HHeN, 16.4% in C3H/HeN, 22.2% in N:GP(SW), and 100% in both C57BL/6N and BDF1 hybrid. The tumor line was maintained in C57BL/6N by transfering in average every 29.7 days and average survival time of these mice was 57 days. Hence, it is believed that this new transplantable spontaneous salivary adenocarcinoma will be a suitable model for investigations in the field of experimantal oncology.