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J Korean Cancer Assoc > Volume 10(1); 1975 > Article
Journal of the Korean Cancer Association 1975;10(1): 13-21.
신종 가이식성 자연발생 마우스타액선 선암 ( 윤선암 ) 의 병리조직학적소견 및 이식율에 대하여
윤탁구
A NEW TRANSPLANTABLE MOUSE SALIVARY ADENOCARCINOMA 7311 ( YUN ADENOCARCINOMA ) OF SPONTANEOUS ORIGIN
Taik Koo Yun
ABSTRACT
The transplantabilities and histological characteristics of a spontaneous transplantable liposarcoma were studied. The tumor was found in the intraperitoneal space of a C3H/HeN female mouse about two years ago during the breeding of inbred animals from the stocks supplied by National Institutes of Health, Bethesda, U.S.A. Grossly, the tumor had whitish-pink or yellowish surface and the tumor tissue was firm. Microscopically it consisted of compactly arranged spindle shaped cells with frequent lipid granules or droplets in the cytoplasm. Even after many continous transplantation, the original histological findings were maintained. Thistumor is transplantable 100 percent in both sexes of the original C3H/HeN mice. However, the percentage of take was reduced to 10 percent in C3H/HeN , 20 percent in DBA/2N, and 25 percent in C3Hf/HeN mice. The transplantability in non-inbred N:GP (SW) mice was 10 percent and BDF1 hybrid mice 36.8 percent. The average transfer day in C3H/HeN mice was 25.6 days, and the average survival time of the transplanted animals was 40 days. The tumor has been carried through 30th transplant generations. It is expected that this transplantable tumor will be useful in the studies of immunotherapy and chemotherap of mesenehymal tumor as well as histogenesis research of liposarcoma.
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A NEW TRANSPLANTABLE MOUSE SALIVARY ADENOCARCINOMA 7108 ( YUN ADENOCARCINOMA ) OF SPONTANEOUS ORIGIN  1975 ;10(1)
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