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Original Article
- Prognostic Value of CEA and CA19 - 9 in Serum and Peritoneal Washing Fluid in Gastric Carcinoma
- Sang Uk Han, Yong Kwan Cho, Seong Woo Hong, Young Ae Lim, Yun Sik Kwak, Myung Wook Kim
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Journal of the Korean Cancer Association 1998;30(5): 869-878.
1Department ofSurgery, Ajou University School of Medicine Suwon, Korea.
2Department of Clinical Pathology, Ajou University School of Medicine Suwon, Korea.
2Department of Clinical Pathology, Ajou University School of Medicine Suwon, Korea.
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Abstract
PURPOSE
The clinical significance of preoperative serum levels of CEA and CA19-9, levels of CEA and CA19-9 in peritoneal washing fluid and free cancer cells in peritoneal washing fluid in gastric cancer patients were evaluated in this study.
MATERIALS AND METHODS
Serum and peritoneal levels of CEA and CA19-9 and peritoneal washing cytology in 115 patients with gastric cancer were analyzed with respect to the prognostic factors using univariate and multivariate analysis.
RESULTS
Positive rate of serum CEA and CA19-9 was 16.5%, 13.0%. And that of peritoneal washing CEA, CA19-9 and cytology was 15.7%, 7.8% and 9.6%. A univariate analysis showed that tumor markets in serum and peritoneal washing fluid and peritoneal washing cytology had significant correlations with the progression of the tumors, and patients with positive serum or peritoneal tumor markers had poorer survival after operation than did the patients with negative tumor markers. But in a multivariate analysis showed that only peritoneal CA19-9 was an independent risk factor. And combination of these five markers provided rnore predictable prognostic informations in a multivariate analysis.
CONCLUSION
Combination of serum or peritoneal levels of CEA, CA19-9 and washing cytology appeared to be a useful marker for managing gastric cancer patients.
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