Glutathione S-transferase P1 Genetic Polymorphisms and Breast Cancer Risk

Kim, Sook Un; Lee, Kyoung Mu; Park, Sue Kyung; Yoo, Keun Young; Noh, Dong Young; Choe, Kook Jin; Ahn, Se Hyun; Kang, Daehee

doi:2002.34.3.205

Cancer Research and Treatment > Volume 34(3); 2002 > Article

Original Article

Cancer Research and Treatment 2002;34(3): 205-211. doi: https://doi.org/10.4143/crt.2002.34.3.205

Glutathione S-transferase P1 Genetic Polymorphisms and Breast Cancer Risk

Sook Un Kim, Kyoung Mu Lee, Sue Kyung Park, Keun Young Yoo, Dong Young Noh, Kook Jin Choe, Se Hyun Ahn, Daehee Kang

¹Department of Preventive Medicine, Seoul National UniversityCollege of Medicine, Seoul, Korea. dhkang@snu.ac.kr
²Department of Surgery, Seoul National University College ofMedicine, Seoul, Korea.
³Department of Preventive Medicine, Konkuk University Collegeof Medicine, Chungju, Korea.
⁴Department of Surgery, Asan Medical Center, Ulsan UniversityCollege of Medicine, Seoul, Korea.

Published online: June 30, 2002.

ABSTRACT

PURPOSE:
To evaluate the potential association between the GSTP1 genotype and the development of breast cancer, a hospital based case-control study was conducted in South Korea. MATERIALS AND METGODS: The study population consisted of 171 histologically confirmed incidents of breast cancer cases, and 171 age-matched controls with no present, or previous, history of cancer. A PCR method was used for the genotyping analyses, and statistical evaluation was performed by an unconditional logistic regression model.
RESULTS:
No association was observed in the study subjects, or the premenopausal women group with GSTP1 Val allele. However, postmenopausal women with GSTP1 Val allele had a reduced risk of breast cancer (OR=0.3, 95% CI=0.1~0.7). When the data were stratified, by the known risk factors of breast cancer, a significant interaction was observed between the GSTP1 genotype and alcohol consumption (p for interaction = 0.01); women with GSTP1 Val allele, that drank regularly, had a 3.0-fold increased risk of breast cancer (95% CI=1.1~7.9), whereas women with GSTP1 Val allele, that never drink, had protective effects (OR=0.4, 95% CI=0.2~0.8).
CONCLUSION:
Our findings suggest that GSTP1 Ile105Val polymorphism influences the individual susceptibility to breast cancer, and that this effect may be modified by alcohol consumption.

Key words: Breast neoplasm;Genetic polymorphism;Glutathione S-transferase