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Cancer Research and Treatment > Accepted Articles
doi: https://doi.org/10.4143/crt.2018.464    [Accepted]
Development of Protocol for Korean Lung Cancer Screening Project (K-LUCAS) to Evaluate Effectiveness and Feasibility to Implement National Cancer Screening Program
Jaeho Lee1, Juntae Lim1,2, Yeol Kim1,2, Hyae Young Kim3, Jin Mo Goo4, Choon-Taek Lee5, Seung Hun Jang6, Won-Chul Lee7, Chan Wha Lee3, Jin Young An8, Ki Dong Ko9, Min Ki Lee10, Kui Son Choi1,2, Boyoung Park1,2, Duk Hyoung Lee1
1National Cancer Control Institute, National Cancer Center, Goyang, Korea
2Department of Cancer Control and Population Health, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea
3Department of Diagnostic Radiology, National Cancer Center, Goyang, Korea
4Department of Radiology, Seoul National University College of Medicine, Seoul National University College of Medicine, Seoul, Korea
5Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University College of Medicine, Seoul, Korea
6Department of Pulmonary, Allergy and Critical Care Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea
7Preventive Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea
8Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea
9Department of Family Medicine, Gachon University Gil Medical Center, Incheon, Korea
10Department of Internal Medicine, Pusan National University, Busan, Korea
Correspondence  Yeol Kim ,Tel: 82-31-920-1934, Fax: 82-31-920-2189, Email: drheat@ncc.re.kr
Received: August 16, 2018;  Accepted: January 19, 2019.  Published online: February 19, 2019.
ABSTRACT
Purpose
To reduce lung cancer mortality, lung cancer screening was recommended using low-dose computed tomography (LDCT) to high risk population. A protocol for multicenter lung cancer screening pilot project was developed to evaluate the effectiveness and feasibility of lung cancer screening to implement national cancer screening program in Korea.
Method
Multidisciplinary expert committee was comprised to develop a standardized protocol forKorean Lung Cancer Screening Project (K-LUCAS). K-LUCAS is a population-based single arm trial that targets high-risk population aged 55-74 years with at least 30 pack-year smoking history. LDCT results are reported by Lung-RADS suggested by American Radiology Society. Network-based system using computer-aided detection program is prepared to assist reducing diagnostic errors. Smoking cessation counselling is provided to all currently smoking participants. A small pilot test was conducted to check the feasibility and compliance of the protocols for K-LUCAS. Result In pilot test, 256 were participated. The average age of participants was 63.2 years and only 3 (1.2%) participants were female. The participants had a smoking history of 40.5 pack-year on average and 53.9% were current smokers. Among them, 86.3% had willing to participate in lung cancer screening again. The average willingness to quit smoking among current smokers was 12.7% higher than before screening. In Lung-RADS reports, 10 (3.9%) were grade 3 and 9 (3.5%) were grade 4. One participant was diagnosed as lung cancer.
Conclusion
The protocol developed by this study is assessed to be feasible to perform K-LUCAS in multicenter nationwide scale.
Key words: Lung neoplasms, Mass screening, Low-dose computed tomography, Smokers, Pilot test
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