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J Korean Cancer Assoc > Volume 28(2); 1996 > Article
Journal of the Korean Cancer Association 1996;28(2): 253-261.
유방암의 Flow Cytometric DNA 분석
서광선, 배진선
Flow Cytometric DNA Analysis of Breast Carcinoma
Kwang Sun Suh, Chin Sun Bae
Nuclear DNA content in 35 cases of breast carcinomas was determined by flow cytometry using paraffin-embedded archival tissue, in order to investigate the correlation between DNA ploidy and pathologic parameters, such as histologic type and degree of differentiation. DNA aneuploidy was found in 18 cases(51.4%). DNA ploidy was correlated with histologic type, tumor grade, and degree of tumar necrosis(P<0.005), but not with patient age, tumor size, or axillary nodal status(P>0.1). There was a tendency for high grade diploid tumors to have a higher S-phase fraction than low grade tumors, although it was statistica11y insignificant. Four patients out of 18 with aneuploid tumors died of breast cancer 10 months to 2 years after operation. However, it was impossible to analyse clinical and pathologic parameters to predict biologic behavior because of the small number of cases and inadequate follow-up data.
Key words: Breast carcinoma, Flow cytometry, DNA ploidy
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