The biologic behavior of human breast cancer reflects on interaction between the intrinsic aggressive potential of the cancer and tumor-retarding cell mediated immunity(CMI). In an attempt to obtain information regarding specific cellular responses to breast cancer, Black and Leis introduced the use of cryostat section of autoiogous breast cancer tissue as target in skin window test(SWT). In order to evaluate the CMI and stimulating ability of PSK to CMI, we performed SWT and Multitest CMI accoding to stage. These findings provide that SWT is an additional aid in evaluation of CMI and immunotherapy snd may eerve as a guide to the individulal therapy.