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J Korean Cancer Assoc > Volume 26(4); 1994 > Article
Journal of the Korean Cancer Association 1994;26(4): 650-657.
쇄골상부 림프절에 전이한 고분화성 흉선암종 - 1예 보고 -
박원서, 정경천, 김철우, 박성회
Invasive Thymoma Metastasizing to Supraclavicular Lymph Node - A case report -
Weon Seo Park, Kyeong Cheon Jung, Chul Woo Kim, Seong Hoe Park
Malignant thymoma is classified into two groups as type I and II according to the clinical features and histologic characteristics. The type I malignant thymoma is called as invasive thymoma and this group of thymoma can invade to mediastinum, lung and cervical lymph node. The type II malignant thymoma is known as thymic carcinoma and categorized inta true malignant tumor which can metastssize to distant organs. However, new disease entity well differentiated thymic carcinoma" was established by some authors based on the histologic features. We have recently experienced a case of invasive thymoma which metastasized to supraclavicular lymph node. The histologic findings of this case showed the same features of well differentiated thymic carcinoma described previously. We report this case with emphasis to pathological examination and immunohistologic characteristics. A 46-year-old male patient admitted because of recurrent and combined pneumonia. Norcardia, pseudomonas, acinetobacter, and Staphylococcus:cus aureus were found in the pleural effusion and sputum. The pneumonic consolidation was found in both lung field and empyema was noted in the left lung field. Multiple lymph nodes were palpable in the left supraclavicular areas. Biopsy was done with the clinical impression of malignancy. Two lymph nodes were excised, measuring 1.0 cm and 0.8 cm respectively. Microscopica11y thge lymph node was replaced with lobulated mass composed of epithelial cells and lymphocytes. The epithelial cells were round to ovoid and had small round eosinophilic and prominent nucleoli. Perivascular palisadng and perivascular spaces, which was described as organoid differentiation of well differentiated thymic carcinoma, were frequently found. The epithelial components were positive to CAM 5.2(anti-cytokeratin antibody). The lymphocytes were positive to JLl and CD45RO, and negative to CD45RB and L26(CD20, pan-B). In conclusion, the tumor showed features of thymoma histologically and immunohistocbemically. Later, it was proved that the patient had experienced thymectomy due to myasthenia gravis six years ago. The pathological features of the excised thymoma were aame as metastatic supraclavicular mass. We conclude that careful examination to search for capsular invasion is needed in thymoma to rule out invasive thymoma. Additionally, anti-JLI monoclonal antibody is useful for the diagnosis of the thymoma, since it is expressed only in the immature cortical thymocytes.
Key words: Invasive thymoma, Extrathoracic metastasis, Supraclavicular lymph node
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