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J Korean Cancer Assoc > Volume 26(1); 1994 > Article
Journal of the Korean Cancer Association 1994;26(1): 169-176.
일차성 고알도스테론증을 유발하는 부신피질암종의 증례보고
이경상, 최웅환정태준, 최일영, 정파종, 박찬금, 이중달,
Primary Hyperaldosteronism Due to Adrenocortical Carcinoma
Kyung Sang Lee, Woong Hwan Choi, Tejune Chung, Il Young Choi, Pah Jong Jung, Chan Kum Park, Jung Dal Lee
Primary hyperaldosteronism resulting from adrenocortical carcinoma is very rare. We have experienced a 39 year old man with adrenocortical csrcinoma presenting with hypertension, hypokalemia, and metabolic alkalosis. The patient had a 13 cm encapsulated mass in his left adrenal gland and multiple metastatic nodules in the lungs. Hyperaldosteronism was established as the cause of the hypertension on the basis of laboratory tests showing suppressed plasma renin activity and nonsuppressible high plasma aldosterone concentration. He has been placed on chemotherapy with cisplatin containing regimen and interferon-a for more than 6 months. He is in stable condition with no evidence of progress in the lung and recurrence in the adrenal gland. A review of the literature revealed only 8 cases with primary hyperaldosteronism resulting from pure aldosterone excess produced by adrenocortical carcinoma. In Korea, oui report is the first one showing clear histologic findings and endocrine tests.
Key words: Adrenocortical csrcinoma, Primary hyperaldosteronism
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