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J Korean Cancer Assoc > Volume 19(2); 1987 > Article
Journal of the Korean Cancer Association 1987;19(2): 79-87.
소세포미분화폐암에서 VIP ( VP-16-213 , Ifosfamide , Cis-Platinum ) 및 CSV ( Cyclophosphamide , Adriamycin , Vincristine ) 복합화학요법의 교대치료
이순남, 허대석, 김노경, 심영수, 김건열, 한용철, 박찬일
Alternating Chemotherapy with VIP ( VP-16-213 , Ifosfamide , Cis-Platinum ) and CSV ( Cyclophosphamide , Adriamycin , Vincristi
Soon Nam Lee, Dae Seog Heo, Noe Kyeong Kim, Young Soo Shim, Keun Youl Kim, Keun Youl Kim, Charn Il Park
Non-cross resistant regimen consisting of VIP rapidly alternating with CAV has been studied in 45 patients with small cell lung cancer. VP-16 60 mg/m i.v. on days 1-5, ifosfamide 1000 mg/m i.v. on days 1-5, and cis-platinum 60 mg/m i.v. on day 1 was alternated at interval of 3 weeks with cyclophosphamide 1000 mg/m i.v. on day 1, adriamycin 45 mg/m i.v. on day 1 and vincristine 1. 4 mg/m i.v. on day 1. For 27 patients with limited disease, indution chemotherapy with one cycle of VIP and CAV was followed by radiotherapy to primary tumor, both supraclavicular lymph nodes and prophylactic whole brain irradiation. Three to four weeks after the completion of radiotherapy, 12 cycles of VIP and CAV were maintained. Eighteen patients with extensive disease were treated with chemotherapy alone. The results obtained were as follows; I) A 92.6% overall response rate and 44.S% complete remission rate in limited disease and 61. 1% overall response rate and 11.1% complete remission rate in extensive disease were achieved. Overall resonse rate in both stage disease was 80.0% and the rate of complete and partial remission was 33.3% and 46.6% respectively. 2) The overall median duration of remission was 49.2 weeks. The median duration of remission was not reached in limited disease group (range, 4-92+weeks) and 34.5 weeks in extensive disease group. The duration of remission for the complete responders was much longer than that for the partial responders (P<0.01).
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