In an attempt to verify the influences of the site of origin and histological grade of ade- nocarcinoma of the stomach on stage grouping, 332 cases who were taken by either cura- tive or palliative surgery were analyzed. Their mean age was 50 +- 2 yrs and the male: female ratio was 2.4 : 1. There was no differences of age diatribution in the light of stage groupings. The commonest site of tumor origin was antrum included angulus (49.1%), and followed by the region of angulus-body (44. 6%) and oardia-fundus (6.3%), the least frequent site. The favorable site of more differentiated tumora waa antrum where is also the least favorable site of stage IV group. On the other hand, lesaer differentiated tumors were predomi- nant in cardia and upper body where is the favorable site of stage IV grc.up. Ninty three percent of stage I group were differentiated cell type, whereas only 35% of stage IV group group were differentiated cell type. Since the lesser differentiated cell type were more frequently observed in stage IV (65.0%) as well as in patients with liver metastasis, the present results may be an indication that stage grouping of advanced adenocarcinoma of the stomach might be influenced by the presence of lesaer differentiated cells in tumor tissues. Hence, we suggest more aggressive Qiagnostic procedures and treatment for theso lesser differentiated tumors of the stomach, even in small size.
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