NBT(Nitroblue tetrazolium) reduction by phagocytic leukocytes was investigated histochemically in 188 cases with and without infections. The mean proportion of NBT positive neutrophis was 10.67 +- 6.24% in healthy children, 30.52 +- 10.48% in healthy newborn infants. Patients with bacterial infection had a mean count of 23.75 +- 10.85, patients with non-infectious illness had a mean count of 10.5 +- 6.14%, Patients with bacterial infection, differ significantly from patients with non-bacterial infection, non-infectious illness. The histochemical NBT test would appear to be a useful adjuntive to microbiologic technique in establishing the diagnosis in patients with suspected bacterial infections.
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