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Cancer Research and Treatment > Accepted Articles
doi: https://doi.org/10.4143/crt.2020.1242    [Accepted]
Risk of Coronavirus Disease Incidence, Severe Presentation, and Mortality in Patients with Lung Cancer
Bumhee Yang1, Hayoung Choi2, Sun-Kyung Lee3,4, Sung Jun Chung3, Yoomi Yeo3, Yoon Mi Shin1, Dong Won Park3, Tai Sun Park3, Ji-Yong Moon3, Tae-Hyung Kim3, Yun Su Sim2, Ho Joo Yoon3, Jang Won Sohn3, Hyun Lee3, Sang-Heon Kim3
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea
2Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea
3Division of Pulmonary Medicine and Allergy, Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea
4Department of Mathematics, College of Natural Sciences, Hanyang University, Seoul, Korea
Correspondence  Hyun Lee ,Tel: 82-2-2290-8350, Fax: 82-2-2298-9183, Email: namuhanayeyo@hanyang.ac.kr
Sang-Heon Kim ,Tel: 82-2-2290-8336, Fax: 82-2-2298-9183, Email: sangheonkim@hanyang.ac.kr
Received: November 25, 2020;  Accepted: December 26, 2020.  Published online: December 28, 2020.
*Bumhee Yang and Hayoung Choi contributed equally to this work.
ABSTRACT
Purpose
This study aimed to analyze whether patients with lung cancer have a higher incidence of coronavirus disease (COVID-19), severe presentation, and higher mortality than those without lung cancer.
Materials and Methods
A nationwide cohort of confirmed COVID-19 (n=8,070) between January 1, 2020, and May 30, 2020, and a 1:15 age-, sex-, and residence-matched cohort (n=121,050) were constructed. A nested case-control study to compare the proportion of patients with lung cancer between the COVID-19 cohort and the matched cohort.
Results
The proportion of patients with lung cancer was significantly higher in the COVID-19 cohort (0.5% [37/8,070]) than in the matched cohort (0.3% [325/121,050]) (p=0.002). The adjusted odds ratio [OR] of having lung cancer was significantly higher in the COVID-19 cohort than in the matched cohort (adjusted OR = 1.51, 95% confidence interval [CI] = 1.05–2.10). Among patients in the COVID-19 cohort, compared to patients without lung cancer, those with lung cancer were more likely to have severe COVID-19 (54.1% vs. 13.2%, p < 0.01), including mortality (18.5% vs. 2.8%, p < 0.01). The adjusted OR for the occurrence of severe COVID-19 in patients with lung cancer relative to those without lung cancer was 2.24 (95% CI = 1.08–4.74).
Conclusion
The risk of COVID-19 incidence and severe presentation, including mortality, may be higher in patients with lung cancer than in those without lung cancer.
Key words: COVID-19, Lung neoplasms, Mortality
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