Cancer Research and Treatment

Original Articles

Pilot Study for Feasibility of Onco-Geriatric Intervention Model in Older Patients with Cancer in a Tertiary Academic Hospital: Jin Won Kim, Jung-Yeon Choi, Woochan Park, Minsu Kang, Jeongmin Seo, Eun Hee Jung, Koung Jin Suh, Ji-Won Kim, Se Hyun Kim, Yu Jung Kim, Keun-Wook Lee, Sang-A Kim, Ji Yun Lee, Jeong-Ok Lee, Soo-Mee Bang, Kwang-il Kim, Jee Hyun Kim; Received January 20, 2025 Accepted March 11, 2025 Published online March 12, 2025; DOI: https://doi.org/10.4143/crt.2025.079 [Accepted]

Abstract PDF: Purpose
Older cancer patients face unique challenges due to age-related physiological changes, increasing their vulnerability to treatment-related toxicities. Geriatric assessment (GA) is a validated tool for optimizing care, yet there is no consensus on integrating geriatric interventions into oncology. This study evaluates the feasibility of a tailored onco-geriatric intervention model incorporating the KG-7 screening tool.
Materials and Methods
This prospective study included 30 patients aged ≥70 years with solid tumors undergoing adjuvant or palliative chemotherapy. Patients scoring ≤5 of KG-7 were eligible. Tailored interventions incorporating KG-7 included polypharmacy, functional status, mobility, nutrition, cognition, emotional well-being, insomnia, social support, and medical problem. KG-7, GA, and quality of life (QoL) were followed at 12 weeks.
Results
Participants (median age: 79.5 years) had colon (43.3%), pancreatic (23.3%), or gastric cancer (23.3%). At baseline, most patients showed independent ADL (100%)/IALD (90%). However, 93.3% had abnormal GA. Particularly, 86.7% were either malnourished or at risk of malnutrition. The most frequently identified intervention needs included polypharmacy (70.0%), nutritional support (60.0%), and emotional well-being (50.0%) with high adherence (100.0%, 88.9%, and 46.7%, respectively). At 12 weeks, KG-7 scores improved in 43.8% of patients, and 69.2% of GA domains were improved. QoL analysis revealed modest improvement in Global Health Status (mean difference 6.3, p=0.176). One-year survival rates were 92.3% and 79.4% for adjuvant and palliative groups, respectively.
Conclusion
The onco-geriatric intervention model incorporating KG-7 demonstrated high feasibility and potential to enhance clinical outcomes. Future studies should validate this approach in randomized trials to optimize care for older cancer patients.

409 View
11 Download

Prospective Validation of The Korean Cancer Study Group Geriatric Score (KG)-7, a Novel Geriatric Screening Tool, in Older Patients with Advanced Cancer Undergoing First-line Palliative Chemotherapy: Jin Won Kim, Se Hyun Kim, Yun-Gyoo Lee, In Gyu Hwang, Jin Young Kim, Su-Jin Koh, Yoon Ho Ko, Seong Hoon Shin, In Sook Woo, Soojung Hong, Tae-Yong Kim, Ji Yeon Baek, Hyun Jung Kim, Hyo Jung Kim, Myung Ah Lee, Jung Hye Kwon, Yong Sang Hong, Hun-Mo Ryoo, Kyung Hee Lee, Jee Hyun Kim; Cancer Res Treat. 2019;51(3):1249-1256. Published online January 2, 2019; DOI: https://doi.org/10.4143/crt.2018.451

Abstract PDF Supplementary Material PubReader ePub

Purpose
The purpose of this study was to prospectively validate the Korean Cancer Study Group Geriatric Score (KG)-7, a novel geriatric screening tool, in older patients with advanced cancer planned to undergo first-line palliative chemotherapy.
Materials and Methods
Participants answered the KG-7 questionnaire before undergoing geriatric assessment (GA) and first-line palliative chemotherapy. The performance of KG-7 was evaluated by calculating the sensitivity (SE), specificity (SP), positive and negative predictive value (PPV and NPV), balanced accuracy (BA), and area under the curve (AUC).
Results
The baseline GA and KG-7 results were collected from 301 patients. The median age was 75 years (range, 70 to 93 years). Abnormal GA was documented in 222 patients (73.8%). Based on the ≤ 5 cut-off value of KG-7 for abnormal GA, abnormal KG-7 score was shown in 200 patients (66.4%). KG-7 showed SE, SP, PPV, NPV, and BA of 75.7%, 59.7%, 84.4%, 46.0%, and 67.7%, respectively; AUC was 0.745 (95% confidence interval, 0.687 to 0.803). Furthermore, patients with higher KG-7 scores showed significantly longer survival (p=0.006).
Conclusion
KG-7 appears to be adequate in identifying patients with abnormal GA prospectively. Hence, KG-7 can be a useful screening tool for Asian countries with limited resources and high patient volume.

Citations

Citations to this article as recorded by

Comparison of two frailty screening tools in older patients with colorectal cancer
Han Zhao, Xinlin Lu, Senshuang Zheng, Danmei Wei, Lizhong Zhao, Yuan Wang, Geertruida H. de Bock, Wenli Lu
BMC Geriatrics.2023;[Epub] CrossRef
Prevalence and Predictive Factors for Upfront Dose Reduction of the First Cycle of First-Line Chemotherapy in Older Adults with Metastatic Solid Cancer: Korean Cancer Study Group (KCSG) Multicenter Study
In Gyu Hwang, Minsuk Kwon, Jin Won Kim, Se Hyun Kim, Yun-Gyoo Lee, Jin Young Kim, Su-Jin Koh, Yoon Ho Ko, Seong Hoon Shin, Soojung Hong, Tae-Yong Kim, Sun Young Kim, Hyun Jung Kim, Hyo Jung Kim, Myung Ah Lee, Jung Hye Kwon, Yong Sang Hong, Kyung Hee Lee,
Cancers.2021; 13(2): 331. CrossRef
A single-arm feasibility study of gradual dose de-escalation of antiemetic dexamethasone for older patients receiving chemotherapy
Koung Jin Suh, Seonghae Yoon, Jin Won Kim, Seo Hyun Yoon, Ji-Won Kim, Se Hyun Kim, Yu Jung Kim, Keun-Wook Lee, Jong Seok Lee, Jee Hyun Kim
Journal of Geriatric Oncology.2021; 12(6): 922. CrossRef
Predictive Value of Geriatric Oncology Screening and Geriatric Assessment in Older Patients with Solid Cancers: Protocol for a Danish prospective cohort study (PROGNOSIS-G8)
Helena Møgelbjerg Ditzel, Ann-Kristine Weber Giger, Cecilia Margareta Lund, Henrik Jørn Ditzel, Afsaneh Mohammadnejad, Per Pfeiffer, Jesper Ryg, Trine Lembrecht Jørgensen, Marianne Ewertz
Journal of Geriatric Oncology.2021; 12(8): 1270. CrossRef
The Globalization of Geriatric Oncology: From Data to Practice
Ravindran Kanesvaran, Supriya Mohile, Enrique Soto-Perez-de-Celis, Harpreet Singh
American Society of Clinical Oncology Educational Book.2020; (40): e107. CrossRef

9,723 View
180 Download
4 Web of Science
5 Crossref

Review Article

Geriatric Oncology: An Overview of Progresses and Challenges: Martine Extermann; Cancer Res Treat. 2010;42(2):61-68. Published online June 30, 2010; DOI: https://doi.org/10.4143/crt.2010.42.2.61

Abstract PDF PubReader ePub

Thanks to the global improvement of health care and living conditions, the world population is aging. Already, in developed countries half of the cancers occur in patients aged 70 and older. In booming Asian nations, such as South Korea, the aging trend is particularly striking, and therefore geriatric oncology is rapidly coming at the foreground of oncology practice. As older patients have a very variable health status, the need for proper integration of an oncologic and a geriatric approach has become increasingly clear. The last two decades have seen the development of geriatric oncology programs and research, which we review here. An increasing amount of data is making clear that a geriatric assessment identifies many problems in older people with cancer, adds prognostic information, and might improve the outcomes of these patients. The near future will likely deliver the following: Operationalization of geriatric assessment into assessment and decision tools, as well as multidisciplinary interventions, in oncology; cooperation of aging and cancer research in the understanding of cancer biology, aging physiology, pharmacology of anticancer drugs; improved clinical study designs; development of geriatric oncology programs, and screening tools accessible to the private practitioner.

Citations

Citations to this article as recorded by

Development of geriatric oncology in Latin America: A report from the Latin American Cooperative Oncology Group
Luciola Pontes Leite de Barros, Ludmila de Oliveira Muniz Koch, Jurema Telles de Oliveira Lima, Thiago Lourenço Apolinario, Aldo Lourenco Abbade Dettino, Cristiane Rios Petrarca, Janine Capobiango Martins, Polianna Mara Rodrigues de Souza, Morgani Rodrigu
Journal of Geriatric Oncology.2024; 15(3): 101642. CrossRef
Psychoonkologische Interventionen bei geriatrischen Tumorpatienten
E. Jentschke, Tamina Jacobi
Die MKG-Chirurgie.2024; 17(3): 182. CrossRef
Cancer in the older Indian population: Understanding the current context in an emerging economy
Suzanne Nethan, Meena Cherian, Etienne Brain, Atreyi Ganguli, Fikru Tullu, Najia Musolino, Roopa Hariprasad, Richard Sullivan, Ravi Mehrotra
Journal of Geriatric Oncology.2022; 13(3): 273. CrossRef
Points de vue d’usagers sur la déprescription de médicaments en maison de retraite
Lucie Lechevalier Hurard, Damien Cateau, Olivier Bugnon, Anne Niquille Charrière, Rose-Anna Foley
Gérontologie et société.2020; vol. 42 / (1): 171. CrossRef
Polypharmacy, limited activity, fatigue and insomnia are the most frequent symptoms and impairments in older hematological cancer survivors (70+): Findings from a register-based study on physical and mental health
Heide Götze, Norbert Köhler, Sabine Taubenheim, Florian Lordick, Anja Mehnert
Journal of Geriatric Oncology.2019; 10(1): 55. CrossRef
Cetuximab monotherapy and cetuximab plus capecitabine as first-line treatment in older patients with RAS- and BRAF wild-type metastatic colorectal cancer. Results of the multicenter phase II trial SAKK 41/10
Dirk L. Kienle, Daniel Dietrich, Karin Ribi, Andreas Wicki, Luca Quagliata, Ralph C. Winterhalder, Dieter Koeberle, Daniel Horber, Sara Bastian, Marc Kueng, Piercarlo Saletti, Daniel Helbling, Daniela Baertschi, Alessandro Lugli, Juerg Bernhard, Christian
Journal of Geriatric Oncology.2019; 10(2): 304. CrossRef
Geriatric Assessment, Not ASA Physical Status, Is Associated With 6-Month Postoperative Survival in Patients With Cancer Aged ≥75 Years
Armin Shahrokni, Bella Marie Vishnevsky, Brian Jang, Saman Sarraf, Koshy Alexander, Soo Jung Kim, Robert Downey, Anoushka Afonso, Beatriz Korc-Grodzicki
Journal of the National Comprehensive Cancer Network.2019; 17(6): 687. CrossRef
Performance of the Multidimensional Geriatric Assessment and Multidimensional Prognostic Index in predicting negative outcomes in older adults with cancer
V. Giantin, C. Falci, E. De Luca, E. Valentini, M. Iasevoli, P. Siviero, S. Maggi, B. Martella, G. Crepaldi, S. Monfardini, E. Manzato
European Journal of Cancer Care.2018; 27(1): e12585. CrossRef
Ältere Patienten (70+) in der Onkologie
Heide Götze, Anja Mehnert
best practice onkologie.2018; 13(2): 80. CrossRef
The impact of age on complications, survival, and cause of death following colon cancer surgery
Christopher T Aquina, Supriya G Mohile, Mohamedtaki A Tejani, Adan Z Becerra, Zhaomin Xu, Bradley J Hensley, Reza Arsalani-Zadeh, Francis P Boscoe, Maria J Schymura, Katia Noyes, John RT Monson, Fergal J Fleming
British Journal of Cancer.2017; 116(3): 389. CrossRef
Therapeutic efficacy of combined PEGylated liposomal doxorubicin and radiofrequency ablation: Comparing single and combined therapy in young and old mice
Alexander V. Andriyanov, Emma Portnoy, Erez Koren, Semenenko Inesa, Sara Eyal, S. Nahum Goldberg, Yechezkel Barenholz
Journal of Controlled Release.2017; 257: 2. CrossRef
Comprehensive Geriatric Assessment and Caring for the Older Person with Cancer
Janine Overcash, Mary Alice Momeyer
Seminars in Oncology Nursing.2017; 33(4): 440. CrossRef
Grassroots inter-professional networks: the case of organizing care for older cancer patients
Fatou Farima Bagayogo, Annick Lepage, Jean-Louis Denis, Lise Lamothe, Liette Lapointe, Isabelle Vedel
Journal of Health Organization and Management.2016; 30(6): 971. CrossRef
Similar survival rates with first-line gefitinib, gemcitabine, or docetaxel in a randomized phase II trial in elderly patients with advanced non-small cell lung cancer and a poor performance status (IFCT-0301)
Gaetan Des Guetz, Thierry Landre, Virginie Westeel, Bernard Milleron, Fabien Vaylet, Thierry Urban, Fabrice Barlesi, Pierre-Jean Souquet, Didier Debieuvre, Denis Braun, Gislaine Fraboulet, Isabelle Monnet, Bernard Uzzan, Olivier Molinier, Franck Morin, De
Journal of Geriatric Oncology.2015; 6(3): 233. CrossRef
Challenges in Cancer Care of Elderly
Virender Suhag, B. S. Sunita, Arti Sarin, A. K. Singh
International Journal of Medical Physics, Clinical Engineering and Radiation Oncology.2015; 04(01): 25. CrossRef
Factors influencing adherence to cancer treatment in older adults with cancer: a systematic review
M.T.E. Puts, H.A. Tu, A. Tourangeau, D. Howell, M. Fitch, E. Springall, S.M.H. Alibhai
Annals of Oncology.2014; 25(3): 564. CrossRef
Is It Helpful to Give Older People with Cancer the Same Chance at Rehabilitation as Older General Medical Patients?
C. Lethborg, R. Brown, S. Posenelli, L. Pollerd, S. Wigg, C. Challis, A. Hocking, C. Whitehall
Journal of Psychosocial Oncology.2014; 32(4): 396. CrossRef
Les fonctions cognitives au commencement d’une nouvelle ligne de traitement chez des patients âgés atteints d’un cancer hématologique
B. Jonius, Y. Libert, I. Bragard, C. Reynaert, D. Razavi, A. -M. Étienne
Psycho-Oncologie.2013; 7(2): 118. CrossRef
Adjuvant Pharmacotherapy in the Management of Elderly Patients with Pancreatic Cancer
Raphaël Maréchal, Anne Demols, Jean-Luc Van Laethem
Drugs & Aging.2013; 30(3): 155. CrossRef
Epidemiology of prostate cancer in the Asia-Pacific region
Peter D. Baade, Danny R. Youlden, Susanna M. Cramb, Jeff Dunn, Robert A. Gardiner
Prostate International.2013; 1(2): 47. CrossRef
Self-perceptions of age among 292 chemotherapy-treated cancer patients: Exploring associations with symptoms and survival
Ming Y. Lim, Elisabeth K. Stephens, Paul Novotny, Katharine Price, Marcia Salayi, Lindsey Roeker, Prema Peethambaram, Aminah Jatoi
Journal of Geriatric Oncology.2013; 4(3): 249. CrossRef
Systemic Treatment of Gastrointestinal Cancer in Elderly Patients
Silvana Leo, Caterina Accettura, Antonio Gnoni, Antonella Licchetta, Marianna Giampaglia, Annamaria Mauro, Valeria Saracino, Brian I. Carr
Journal of Gastrointestinal Cancer.2013; 44(1): 22. CrossRef
Evaluation of the cardiovascular health study (CHS) instrument and the Vulnerable Elders Survey-13 (VES-13) in elderly cancer patients. Are we still missing the right screening tool?
L. Biganzoli, L. Boni, D. Becheri, E. Zafarana, C. Biagioni, S. Cappadona, E. Bianchini, C. Oakman, S.U. Magnolfi, A. Di Leo, G. Mottino
Annals of Oncology.2013; 24(2): 494. CrossRef
Influence of age on the pharmacokinetics of i.v. vinflunine: Results of a phase I trial in elderly cancer patients
J.M. Tourani, L. Mourey, V. Servent, T. Nguyen, A. Ravaud, V. Girre, S. Favrel, M.C. Pinel, N. Isambert
Journal of Geriatric Oncology.2012; 3(1): 41. CrossRef
Influence of Comorbidities on the Efficacy of Radiotherapy with or without Chemotherapy in Elderly Stage III Non-small Cell Lung Cancer Patients
Joo Ho Lee, Hong-Gyun Wu, Hak Jae Kim, Dong-Wan Kim, Se-Hoon Lee, Tae Min Kim, Young Whan Kim, Dae Seog Heo
Cancer Research and Treatment.2012; 44(4): 242. CrossRef
Enhancing life after cancer in diverse communities
Judith S. Kaur, Kathryn Coe, Julia Rowland, Kathryn L. Braun, Francisco A. Conde, Linda Burhansstipanov, Sue Heiney, Marjorie Kagawa‐Singer, Qian Lu, Catherine Witte
Cancer.2012; 118(21): 5366. CrossRef
Therapeutic options in older patients with metastatic non-small cell lung cancer
Elisabeth Quoix
Therapeutic Advances in Medical Oncology.2012; 4(5): 247. CrossRef
Advanced non-small cell lung cancer in elderly patients
Elisabeth Quoix
Breathe.2012; 9(1): 26. CrossRef
Évaluation des sujets âgés avant traitement
E. Quoix
Revue des Maladies Respiratoires Actualités.2011; 3(4): 285. CrossRef
Optimal Pharmacotherapeutic Strategies for Elderly Patients with Advanced Non-Small Cell Lung Cancer
Elisabeth Quoix
Drugs & Aging.2011; 28(11): 885. CrossRef
Anticancer Drug Use in Geriatric Patients: Concerns and Challenges
Denys T. Lau, Mary H. Jarzebowski, June M. McKoy
Clinical Therapeutics.2011; 33(10): 1408. CrossRef
Prevention of Neutropenia-Related Events in Elderly Patients with Hematological Cancer
Jean Klastersky, Andrea Gombos, Aspasia Georgala, Ahmad Awada
Aging Health.2011; 7(6): 829. CrossRef
Prostate cancer: an emerging threat to the health of aging men in Asia
Ling Zhang, Bao-Xue Yang, Hai-Tao Zhang, Jin-Guo Wang, Hong-Liang Wang, Xue-Jian Zhao
Asian Journal of Andrology.2011; 13(4): 574. CrossRef
Systemic Therapy for Elderly Patients with Gastrointestinal Cancer
Joleen M. Hubbard, Axel Grothey, Daniel J. Sargent
Clinical Medicine Insights: Oncology.2011;[Epub] CrossRef
Major clinical research advances in gynecologic cancer in 2010
Dong Hoon Suh, Jae Weon Kim, Kidong Kim, Soon-Beom Kang
Journal of Gynecologic Oncology.2010; 21(4): 209. CrossRef

11,452 View
96 Download
35 Crossref

First
Prev
Page of 1
Next
Last

Search