Cancer Research and Treatment

Original Articles

Gastrointestinal cancer

Colonoscopic Screening and Risk of All-Cause and Colorectal Cancer Mortality in Young and Older Individuals: Jung Ah Lee, Yoosoo Chang, Yejin Kim, Dong-Il Park, Soo-Kyung Park, Hye Yin Park, Jaewoo Koh, Soo-Jin Lee, Seungho Ryu; Cancer Res Treat. 2023;55(2):618-625. Published online September 19, 2022; DOI: https://doi.org/10.4143/crt.2022.852

Abstract PDF Supplementary Material PubReader ePub

Purpose
The incidence of early-onset colorectal cancer (CRC) and associated mortality have been increasing. However, the potential benefits of CRC screening are largely unknown in young individuals. We aimed to evaluate the effect of CRC screening with colonoscopy on all-cause and CRC mortality among young (aged < 45 years) and older (aged ≥ 45 years) individuals.
Materials and Methods
This cohort study included 528,046 Korean adults free of cancer at baseline who underwent a comprehensive health examination. The colonoscopic screening group was defined as those who reported undergoing colonoscopy for CRC screening. Mortality follow-up until December 31, 2019 was ascertained based on nationwide death certificate data from the Korea National Statistical Office.
Results
Colonoscopic screening was associated with a lower risk of all-cause mortality in both young and older individuals. Multivariable-adjusted time-dependent hazard ratios (95% confidence intervals) for all-cause mortality comparing ever- to never-screening were 0.86 (0.75-0.99) for young individuals and 0.71 (0.65-0.78) for older individuals. Colonoscopic screenings were also associated with a reduced risk of CRC mortality without significant interaction by age, although this association was significant only among participants aged ≥ 45 years, with corresponding time-dependent hazard ratios of 0.47 (0.15-1.44) for young individuals and 0.52 (0.31-0.87) for those aged ≥ 45 years.
Conclusion
Colonoscopic CRC screening decreased all-cause mortality among both young and older individuals, while significantly decreased CRC mortality was observed only in those aged ≥ 45 years. Screening initiation at an earlier age warrants more rigorous confirmatory studies.

Citations

Citations to this article as recorded by

Effect of screening mammography on the risk of breast cancer deaths and of all-cause deaths: a systematic review with meta-analysis of cohort studies
Philippe Autier, Karsten Juhl Jørgensen, Michel Smans, Henrik Støvring
Journal of Clinical Epidemiology.2024; 172: 111426. CrossRef
Identifying Gaps in Early-Onset Colorectal Cancer Prevention, Screening, and Treatment in the Philippines
Luis Miguel B. Co, Robyn Gayle K. Dychiao, Michael Paolo R. Capistrano, Manolito T. Tayag, Erika P. Ong, Frances Dominique V. Ho, Michelle Ann B. Eala, Henri Cartier Co, Edward Christopher Dee, Marie Dione P. Sacdalan, Dennis L. Sacdalan
Annals of Surgical Oncology.2024; 31(12): 7685. CrossRef
Association between colonoscopy and colorectal cancer occurrence and mortality in the older population: a population-based cohort study
Ji Young Lee, Jae Myung Cha, Jin Young Yoon, Min Seob Kwak, Hun Hee Lee
Endoscopy.2024;[Epub] CrossRef
Rising incidence and impact of early‐onset colorectal cancer in the Asia‐Pacific with higher mortality in females from Southeast Asia: a global burden analysis from 2010 to 2019
Pojsakorn Danpanichkul, Pinyada Moolkaew, Yatawee Kanjanakot, Natchaya Polpichai, Aunchalee Jaroenlapnopparat, Donghee Kim, Frank J. Lukens, Wahid Wassef, Michael B. Fallon, Vincent L. Chen, Rashid Lui, Karn Wijarnpreecha
Journal of Gastroenterology and Hepatology.2023; 38(12): 2053. CrossRef

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Lung Cancer

Clinical Significance of Acute Kidney Injury in Lung Cancer Patients: Semin Cho, Eunjeong Kang, Ji Eun Kim, U Kang, Hee Gyung Kang, Minsu Park, Kwangsoo Kim, Dong Ki Kim, Kwon Wook Joo, Yon Su Kim, Hyung-Jin Yoon, Hajeong Lee; Cancer Res Treat. 2021;53(4):1015-1023. Published online January 18, 2021; DOI: https://doi.org/10.4143/crt.2020.1010

Abstract PDF Supplementary Material PubReader ePub

Purpose
Acute kidney injury (AKI) in cancer patients is associated with increased morbidity and mortality. The incidence of AKI in lung cancer seems to be relatively higher compared with other solid organ malignancies, although its impact on patient outcomes remains unclear.
Materials and Methods
The patients newly diagnosed with lung cancer from 2004 to 2013 were enrolled in this retrospective cohort study. The patients were categorized according to the presence and severity of AKI. We compared all-cause mortality and long-term renal outcome according to AKI stage.
Results
A total of 3,202 patients were included in the final analysis. AKI occurred in 1,783 (55.7%) patients during the follow-up period, with the majority having mild AKI stage 1 (75.8%). During the follow-up of 2.6±2.2 years, total 1,251 patients (53.7%) were died and 5-year survival rate was 46.9%. We found that both AKI development and severity were independent risk factors for all-cause mortality in lung cancer patients, even after adjustment for lung cancer-specific variables including the stage or pathological type. In addition, patients suffered from more severe AKI tend to encounter de novo chronic kidney disease development, worsening kidney function, and end-stage kidney disease progression.
Conclusion
In this study, more than half of the lung cancer patients experienced AKI during their diagnosis and treatment period. Moreover, AKI occurrence and more advanced AKI were associated with a higher mortality risk and adverse kidney outcomes.

Citations

Citations to this article as recorded by

Acute kidney injury associated with anti-PD-1 and anti-PD-L1 drugs: a meta-analysis of randomized clinical trials
Isabela Gonçalves Lima, Isabele Benck Usiro Cabral da Silva, Vitória Carpentieri Pípolo, Vinicius Daher Alvares Delfino, Paulo Roberto Bignardi
Immunopharmacology and Immunotoxicology.2024; 46(4): 470. CrossRef
Prevalence of kidney disease in patients with different types of cancer or hematological malignancies: a cross-sectional study
Feng Wu, Shiyuan Wang, Jialing Zhang, Peixin Wang, Aihua Zhang
International Urology and Nephrology.2024; 56(12): 3835. CrossRef
Protective effect of reduced glutathione on acute kidney injury in lung cancer patients treated with cisplatin: a retrospective cohort study
Ying Huang, Yang Li, Xialian Xu, Jie Teng, Xiaoqiang Ding, Jiarui Xu
Renal Failure.2024;[Epub] CrossRef
Association between renal dysfunction and outcomes of lung cancer: A systematic review and meta‑analysis
Huijuan Qian, Si Li, Ziyun Hu
Oncology Letters.2024;[Epub] CrossRef
Association and prediction of red blood cell distribution width to albumin ratio in all-cause mortality of acute kidney injury in critically ill patients
Chen Gao, Longkai Peng
Frontiers in Medicine.2023;[Epub] CrossRef
Point of care ultrasonography in onco-nephrology: A stride toward better physical examination
Bhavna Bhasin-Chhabra, Abhilash Koratala
World Journal of Nephrology.2023; 12(2): 29. CrossRef
Protocolo diagnóstico y tratamiento de la nefropatía en los pacientes con neoplasia sólida
Rodríguez Doyágüez, M.P. Morán Magro, C.M. Durán López, P. Martínez Miguel
Medicine - Programa de Formación Médica Continuada Acreditado.2023; 13(82): 4870. CrossRef

7,459 View
194 Download
6 Web of Science
7 Crossref

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