Cancer Research and Treatment

Original Articles

An Open-Label, Randomized, Parallel, Phase II Trial to Evaluate the Efficacy and Safety of a Cremophor-Free Polymeric Micelle Formulation of Paclitaxel as First-Line Treatment for Ovarian Cancer: A Korean Gynecologic Oncology Group Study (KGOG-3021): Shin-Wha Lee, Yong-Man Kim, Chi Heum Cho, Young Tae Kim, Seok Mo Kim, Soo Young Hur, Jae-Hoon Kim, Byoung-Gie Kim, Seung-Cheol Kim, Hee-Sug Ryu, Soon Beom Kang; Cancer Res Treat. 2018;50(1):195-203. Published online March 21, 2017; DOI: https://doi.org/10.4143/crt.2016.376

Purpose
Genexol-PM is a biodegradable cremophor EL–free polymeric micelle formulation of paclitaxel. Here,we compared efficacy and safety of Genexol-PM plus carboplatin versus Genexol plus carboplatin for ovarian cancer treatment.
Materials and Methods
In this multicenter, randomized, phase II study, patients with International Federation of Gynecology and Obstetrics IC-IV epithelial ovarian cancer were randomly assigned (1:1) to receive Genexol-PM 260 mg/m² or Genexol 175 mg/m² with 5 area under the curve carboplatin every 3weeks (6 cycles). The primary endpointwas the carbohydrate antigen 125 and Response Evaluation Criteria In Solid Tumor composite overall response rate (ORR).
Results
Of 131 enrolled patients, 98 were included in intention-to-treat analysis. Mean dosages were 260.00±0.00 mg/m² Genexol-PM or 174.24±3.81 mg/m² Genexol. Median followup was 18.0 months (range, 6.1 to 33.8 months). ORR was 88.0% (95% confidence interval [CI], 80.4 to 95.6) with Genexol-PM, and 77.1% (95% CI, 67.1 to 87.1) with Genexol (noninferiority threshold, 16.3%). Median time to progression was 14.8 months (95% CI, 11.3 to 20.2) with Genexol-PM and 15.4 months (95% CI, 13.2 to 29.6) with Genexol (p=0.550). Overall, six patients died. Neutropenia was the most common toxicity (incidences of 86.0% vs. 77.1%, p=0.120). Peripheral neuropathy incidences were 84.0% versus 64.6% (p= 0.148). Peripheral neuropathy of ≥ grade 3 occurred in one patient receiving Genexol. All toxicities were manageable.
Conclusion
Genexol-PM plus carboplatin as first-line treatment in patients with epithelial ovarian cancer demonstrated non-inferior efficacy and well-tolerated toxicities compared with the standard paclitaxel regimen. Further studies are warranted to optimize the dose and schedule, and to investigate long-term outcomes.

Citations

Citations to this article as recorded by

Medical nanoscale materials for virus-induced cervical cancer therapeutic modalities: For targeting delivery
Adane Adugna, Mamaru Getinet, Gashaw Azanaw Amare, Mohammed Jemal
OpenNano.2025; 21: 100221. CrossRef
From Pioneering Discoveries to Innovative Therapies: A Journey Through the History and Advancements of Nanoparticles in Breast Cancer Treatment
Fatemah Basingab, Omniah Alshahrani, Ibtehal Alansari, Nada Almarghalani, Nada Alshelali, Abeer Alsaiary, Najwa Alharbi, Kawther Zaher
Breast Cancer: Targets and Therapy.2025; Volume 17: 27. CrossRef
PD-L1-Targeting Nanoparticles for the Treatment of Triple-Negative Breast Cancer: A Preclinical Model
Wendy K. Nevala, Liyi Geng, Hui Xie, Noah A. Stueven, Svetomir N. Markovic
International Journal of Molecular Sciences.2025; 26(7): 3295. CrossRef
Nano-drug delivery systems based on biodegradable polymers for the therapy of gynecological malignancies
Keer Jin, Hanxue Zhang, Yuwei Yang, Yan Gao
International Journal of Polymeric Materials and Polymeric Biomaterials.2024; 73(14): 1262. CrossRef
Dual stimuli-responsive polymeric prodrug consisting of reversible covalent bonded celastrol for tumor targeted delivery
Jiangtao Su, Meng Rao, Heshuang Dai, Le Cai, Fan Ye, Lu Ye, Yuchen Hu, Ban Chen, Xiaoxia Guo
Macromolecular Research.2024; 32(2): 173. CrossRef
Designing nanodiscs as versatile platforms for on-demand therapy
Qianwen Mu, Haolan Deng, Xiaoyu An, Gang Liu, Chao Liu
Nanoscale.2024; 16(5): 2220. CrossRef
Innovative strategies for effective paclitaxel delivery: Recent developments and prospects
Sławomir Wileński, Agnieszka Koper, Paulina Śledzińska, Marek Bebyn, Krzysztof Koper
Journal of Oncology Pharmacy Practice.2024; 30(2): 367. CrossRef
Platelet-derived drug delivery systems: Pioneering treatment for cancer, cardiovascular diseases, infectious diseases, and beyond
Yalan Zhu, Lingling Xu, Yong Kang, Qinzhen Cheng, Yiling He, Xiaoyuan Ji
Biomaterials.2024; 306: 122478. CrossRef
Nanoparticle-Based Immunotherapy for Reversing T-Cell Exhaustion
Fei Li, Yahong Wang, Dandan Chen, Yunjie Du
International Journal of Molecular Sciences.2024; 25(3): 1396. CrossRef
Delivery of Nucleic Acid Drugs for Tumor Therapy: Opportunities and Challenges
Dandan Sun, Wenjia Tan, Jianan Zhao, Yafei Tian, Siqi Li, Zhiqi Zhang, Xinzhe Dong, Xiaonan Liu, Na Liu, Ping Jiao, Jie Ma
Fundamental Research.2024;[Epub] CrossRef
Effect of high-dose polymeric nanoparticle micellar paclitaxel on improved progression-free survival in patients with optimally resected stage III or IV high-grade carcinoma of the ovary: a prospective cohort study with historical controls
Soo Jin Park, Joo-Hyuk Son, Tae-Wook Kong, Suk-Joon Chang, Hee Seung Kim
Frontiers in Oncology.2024;[Epub] CrossRef
Co-Assembly of Cancer Drugs with Cyclo-HH Peptides: Insights from Simulations and Experiments
Anastasia Vlachou, Vijay Bhooshan Kumar, Om Shanker Tiwari, Sigal Rencus-Lazar, Yu Chen, Busra Ozguney, Ehud Gazit, Phanourios Tamamis
ACS Applied Bio Materials.2024; 7(4): 2309. CrossRef
Biomarkers in Ovarian Cancer: Towards Personalized Medicine
Carlos López-Portugués, María Montes-Bayón, Paula Díez
Proteomes.2024; 12(1): 8. CrossRef
Internalization of transferrin-tagged Myxococcus xanthus encapsulins into mesenchymal stem cells
Anna N. Gabashvili, Natalya A. Alexandrushkina, Elizaveta N. Mochalova, Daria V. Goliusova, Ekaterina N. Sapozhnikova, Pavel I. Makarevich, Petr I. Nikitin
Experimental Biology and Medicine.2024;[Epub] CrossRef
Functionalized Polymeric Micelles for Targeted Cancer Therapy: Steps from Conceptualization to Clinical Trials
Ana Serras, Célia Faustino, Lídia Pinheiro
Pharmaceutics.2024; 16(8): 1047. CrossRef
Polyesters and Polyester Nano- and Microcarriers for Drug Delivery
Stanislaw Slomkowski, Teresa Basinska, Mariusz Gadzinowski, Damian Mickiewicz
Polymers.2024; 16(17): 2503. CrossRef
Nanotheranostics for gynecological cancers: a path forward for Africa
Mutia Kehwalla Aza, Anavami Suberu, Mahmood Balogun, Goodness Adegbola, Mohamed Alie Sankoh, Thomas Oyediran, Nicholas Aderinto, Gbolahan Olatunji, Emmanuel Kokori, Chinonyelum Emmanuel Agbo
Medical Oncology.2024;[Epub] CrossRef
Pharmacokinetic behaviors of soft nanoparticulate formulations of chemotherapeutics
Mahua Sarkar, Yang Wang, Oscar Ekpenyong, Dong Liang, Huan Xie
WIREs Nanomedicine and Nanobiotechnology.2023;[Epub] CrossRef
Cancer treatment and toxicity outlook of nanoparticles
Neetika, Mamta Sharma, Pankaj Thakur, Paras Gaur, Gokana Mohana Rani, Sarvesh Rustagi, Rishi Kumar Talreja, Vishal Chaudhary
Environmental Research.2023; 237: 116870. CrossRef
Efficacy and Safety of Nanopaclitaxel Formulation for Cancer Treatment: Evidence From Randomized Clinical Trials
Xiangmin Deng, Xiaoqin Huang, Xiaoyan Dong, Genxiang Mao, Wenmin Xing
Nanomedicine.2023; 18(10): 833. CrossRef
Development and Perspectives: Multifunctional Nucleic Acid Nanomedicines for Treatment of Gynecological Cancers
Tetiana Korzun, Abraham S. Moses, Parham Diba, Ariana L. Sattler, Brennan Olson, Olena R. Taratula, Tanja Pejovic, Daniel L. Marks, Oleh Taratula
Small.2023;[Epub] CrossRef
Nanoprobe-based molecular imaging for tumor stratification
Xianbin Ma, Mingchuan Mao, Jiaqi He, Chao Liang, Hai-Yan Xie
Chemical Society Reviews.2023; 52(18): 6447. CrossRef
Magic shotgun over magic bullet for treatment of ovarian cancer via polymeric nanoparticles
Bakr Ahmed, Anuradha Sharma, Zakiya Usmani, Garima Sharma, Joga Singh, Radhika Yadav, Indu Sharma, Indu Pal Kaur
Journal of Drug Delivery Science and Technology.2023; 88: 104945. CrossRef
Safety and Tolerability of Weekly Genexol-PM, a Cremophor-Free Polymeric Micelle Formulation of Paclitaxel, with Carboplatin in Gynecologic Cancer: A Phase I Study
So Hyun Nam, Shin-Wha Lee, Young-Jae Lee, Yong Man Kim
Cancer Research and Treatment.2023; 55(4): 1346. CrossRef
Effective Cancer Management: Inimitable Role of Phytochemical Based Nano- Formulations
Aman Upaganlawar, Satish Polshettiwar, Sushil Raut, Amol Tagalpallewar, Vishal Pande
Current Drug Metabolism.2022; 23(11): 869. CrossRef
Comparison of triblock copolymeric micelles based on α- and ε-poly(L-lysine): a Cornelian choice
Franck Marquet, Viorica Patrulea, Gerrit Borchard
Polymer Journal.2022; 54(2): 199. CrossRef
Neurosurgery at the crossroads of immunology and nanotechnology. New reality in the COVID-19 pandemic
Vladimir A. Ljubimov, Arshia Ramesh, Saya Davani, Moise Danielpour, Joshua J. Breunig, Keith L. Black
Advanced Drug Delivery Reviews.2022; 181: 114033. CrossRef
Nanocarriers targeting the diseases of the pancreas
Nurbanu Demirtürk, Erem Bilensoy
European Journal of Pharmaceutics and Biopharmaceutics.2022; 170: 10. CrossRef
The development and progress of nanomedicine for esophageal cancer diagnosis and treatment
Xiaokun Li, Lingmin Chen, Siyuan Luan, Jianfeng Zhou, Xin Xiao, Yushang Yang, Chengyi Mao, Pinhao Fang, Longqi Chen, Xiaoxi Zeng, Huile Gao, Yong Yuan
Seminars in Cancer Biology.2022; 86: 873. CrossRef
Beyond separation: Membranes towards medicine
Ying Xie, Zhenyu Chu, Wanqin Jin
Journal of Membrane Science Letters.2022; 2(1): 100020. CrossRef
Modulation of TLR/NF-κB/NLRP Signaling by Bioactive Phytocompounds: A Promising Strategy to Augment Cancer Chemotherapy and Immunotherapy
Sajad Fakhri, Seyed Zachariah Moradi, Akram Yarmohammadi, Fatemeh Narimani, Carly E. Wallace, Anupam Bishayee
Frontiers in Oncology.2022;[Epub] CrossRef
Gold Nanorods for Drug and Gene Delivery: An Overview of Recent Advancements
Atieh Jahangiri-Manesh, Marziyeh Mousazadeh, Shirinsadat Taji, Abbas Bahmani, Atefeh Zarepour, Ali Zarrabi, Esmaeel Sharifi, Mostafa Azimzadeh
Pharmaceutics.2022; 14(3): 664. CrossRef
Gene Therapy for Malignant and Benign Gynaecological Disorders: A Systematic Review of an Emerging Success Story
Ekati Drakopoulou, Nicholas P. Anagnou, Kalliopi I. Pappa
Cancers.2022; 14(13): 3238. CrossRef
Engineering nanosystems to overcome barriers to cancer diagnosis and treatment
Suhaila O. Alhaj-Suliman, Emad I. Wafa, Aliasger K. Salem
Advanced Drug Delivery Reviews.2022; 189: 114482. CrossRef
Metabolic Signatures of Surface-Modified Poly(lactic-co-glycolic acid) Nanoparticles in Differentiated THP-1 Cells Derived with Liquid Chromatography-Mass Spectrometry-based Metabolomics
Mohammad A. Al-natour, Salah Abdelrazig, Amir M. Ghaemmaghami, Cameron Alexander, Dong-Hyun Kim
ACS Omega.2022; 7(33): 28806. CrossRef
Pathogen-derived peptides in drug targeting and its therapeutic approach
Seok-Jun Mun, Euni Cho, Jae-Sung Kim, Chul-Su Yang
Journal of Controlled Release.2022; 350: 716. CrossRef
Application of single and cooperative different delivery systems for the treatment of intervertebral disc degeneration
Zongtai Liu, Changfeng Fu
Frontiers in Bioengineering and Biotechnology.2022;[Epub] CrossRef
Engineering the Tumor Immune Microenvironment through Minimally Invasive Interventions
Koustav Pal, Rahul A. Sheth
Cancers.2022; 15(1): 196. CrossRef
Nanoparticle delivery systems to combat drug resistance in ovarian cancer
Emily M. Miller, Timothy M. Samec, Angela A. Alexander-Bryant
Nanomedicine: Nanotechnology, Biology and Medicine.2021; 31: 102309. CrossRef
Engineering precision nanoparticles for drug delivery
Michael J. Mitchell, Margaret M. Billingsley, Rebecca M. Haley, Marissa E. Wechsler, Nicholas A. Peppas, Robert Langer
Nature Reviews Drug Discovery.2021; 20(2): 101. CrossRef
Clinical applications of nanomedicines in lung cancer treatment
Mohammad Norouzi, Pierre Hardy
Acta Biomaterialia.2021; 121: 134. CrossRef
Lyophilization stabilizes clinical‐stage core‐crosslinked polymeric micelles to overcome cold chain supply challenges
Tarun Ojha, Qizhi Hu, Claudio Colombo, Jan Wit, Michiel van Geijn, Mies J. van Steenbergen, Mahsa Bagheri, Hiltrud Königs‐Werner, Eva Miriam Buhl, Ruchi Bansal, Yang Shi, Wim E. Hennink, Gert Storm, Cristianne J. F. Rijcken, Twan Lammers
Biotechnology Journal.2021;[Epub] CrossRef
Development of next generation nanomedicine-based approaches for the treatment of cancer: we've barely scratched the surface
Shannon R. Tracey, Peter Smyth, Caroline J. Barelle, Christopher J. Scott
Biochemical Society Transactions.2021; 49(5): 2253. CrossRef
Impact of Value Frameworks on the Magnitude of Clinical Benefit: Evaluating a Decade of Randomized Trials for Systemic Therapy in Solid Malignancies
Ellen Cusano, Chelsea Wong, Eddy Taguedong, Marcus Vaska, Tasnima Abedin, Nancy Nixon, Safiya Karim, Patricia Tang, Daniel Y. C. Heng, Doreen Ezeife
Current Oncology.2021; 28(6): 4894. CrossRef
Engineering Considerations to Produce Bioactive Compounds from Plant Cell Suspension Culture in Bioreactors
Elizabeth Alejandra Motolinía-Alcántara, Carlos Omar Castillo-Araiza, Mario Rodríguez-Monroy, Angélica Román-Guerrero, Francisco Cruz-Sosa
Plants.2021; 10(12): 2762. CrossRef
Clinical applications of nanomedicine in cancer therapy
Mohammad Norouzi, Mehrnaz Amerian, Mahshid Amerian, Fatemeh Atyabi
Drug Discovery Today.2020; 25(1): 107. CrossRef
Targeting and extending the eukaryotic druggable genome with natural products: cytoskeletal targets of natural products
April L. Risinger, Lin Du
Natural Product Reports.2020; 37(5): 634. CrossRef
Improvement of Paclitaxel-Associated Adverse Reactions (ADRs) via the Use of Nano-Based Drug Delivery Systems: A Systematic Review and Network Meta-Analysis

Pi-Ling Chou, Ya-Ping Huang, Meng-Hsuan Cheng, Kun-Ming Rau, Yi-Ping Fang
International Journal of Nanomedicine.2020; Volume 15: 1731. CrossRef
Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval
Duhyeong Hwang, Jacob D. Ramsey, Alexander V. Kabanov
Advanced Drug Delivery Reviews.2020; 156: 80. CrossRef
Nanoparticles in precision medicine for ovarian cancer: From chemotherapy to immunotherapy
Yuan Li, Yan Gao, Xi Zhang, Hongyan Guo, Huile Gao
International Journal of Pharmaceutics.2020; 591: 119986. CrossRef
Synthesis of PCL–PEG–PCL Triblock Copolymer via Organocatalytic Ring-Opening Polymerization and Its Application as an Injectable Hydrogel—An Interdisciplinary Learning Trial
Kaiting Wu, Lin Yu, Jiandong Ding
Journal of Chemical Education.2020; 97(11): 4158. CrossRef
Phytochemical-Based Nanomedicine for Advanced Cancer Theranostics: Perspectives on Clinical Trials to Clinical Use

Madhusmita Dhupal, Devasish Chowdhury
International Journal of Nanomedicine.2020; Volume 15: 9125. CrossRef
Synthesis and anti-cancer evaluation of folic acid-peptide- paclitaxel conjugates for addressing drug resistance
Yuxuan Dai, Xingguang Cai, Xinzhou Bi, Chunxia Liu, Na Yue, Ying Zhu, Jiaqi Zhou, Mian Fu, Wenlong Huang, Hai Qian
European Journal of Medicinal Chemistry.2019; 171: 104. CrossRef
A Phase II Study of Genexol-PM and Cisplatin as Induction Chemotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma
Bhumsuk Keam, Keun-Wook Lee, Se-Hoon Lee, Jin-Soo Kim, Jin Ho Kim, Hong-Gyun Wu, Keun-Yong Eom, Suzy Kim, Soon-Hyun Ahn, Eun-Jae Chung, Seong Keun Kwon, Woo-Jin Jeong, Young Ho Jung, Ji-Won Kim, Dae Seog Heo
The Oncologist.2019; 24(6): 751. CrossRef
Polymeric Hybrid Nanomicelles for Cancer Theranostics: An Efficient and Precise Anticancer Strategy for the Codelivery of Doxorubicin/miR-34a and Magnetic Resonance Imaging
Xiaoxue Xie, Yu Chen, Zhongyuan Chen, Yi Feng, Jing Wang, Tingting Li, Shun Li, Xiang Qin, Chunhui Wu, Chuan Zheng, Jie Zhu, Fengming You, Yiyao Liu, Hong Yang
ACS Applied Materials & Interfaces.2019; 11(47): 43865. CrossRef
Micellar paclitaxel in the treatment of patients with tumors of the female reproductive system
A. G. Kedrova, S. E. Krasilnikov, D. A. Astakhov, V. V. Kosyy
Tumors of female reproductive system.2019; 15(3): 37. CrossRef
Improving Drug Delivery of Micellar Paclitaxel against Non‐Small Cell Lung Cancer by Coloading Itraconazole as a Micelle Stabilizer and a Tumor Vascular Manipulator
Ling Zhang, Zhengsheng Liu, Chao Kong, Chun Liu, Kuan Yang, Huijun Chen, Jinfeng Huang, Feng Qian
Small.2018;[Epub] CrossRef

13,783 View
362 Download
60 Web of Science
57 Crossref

The Impact of High-Risk HPV Genotypes Other Than HPV 16/18 on the Natural Course of Abnormal Cervical Cytology: A Korean HPV Cohort Study: Kyeong A So, Mi Jung Kim, Ki-Heon Lee, In-Ho Lee, Mi Kyung Kim, Yoo Kyung Lee, Chang-Sun Hwang, Mi Seon Jeong, Mee-Kyung Kee, Chun Kang, Chi Heum Cho, Seok Mo Kim, Sung Ran Hong, Ki Tae Kim, Won-Chul Lee, Jong Sup Park, Tae Jin Kim; Cancer Res Treat. 2016;48(4):1313-1320. Published online March 9, 2016; DOI: https://doi.org/10.4143/crt.2016.013

Abstract PDF PubReader ePub

Purpose
The purpose of this study is to evaluate the impact of high-risk human papillomaviruses (HPVs) other than HPV 16/18 on the natural course of atypical squamous cells of undetermined significance (ASC-US) or low-grade squamous intraepithelial lesion (LSIL).
Materials and Methods
The study population was derived from the Korean HPV cohort (2010-2014). Women aged 20 to 60 who satisfied the criteria of having both HPV infection and abnormal cervical cytology of either ASC-US or LSIL were recruited from five institutions nationwide. Enrolled patients underwent cervical cytology and HPV DNA testing every 6 months.
Results
A total of 1,158 patients were enrolled. The 10 most common HPV types were HPV 16 (12.3%), 58 (10.0%), 56 (8.8%), 53 (8.4%), 52 (7.7%), 39 (6.2%), 18 (6.0%), 51 (5.7%), 68 (5.1%), and 66 (4.6%). Among these patients, 636 women were positive for high-risk HPVs other than HPV 16 or 18, and 429 women were followed for more than 6 months. Cytology evaluations showed progression in 15.3% of women, no change in 22.6%, and regression in 62.1% of women at 12 months. In cases of HPV 58 single infection, a more highly significant progression rate, compared to other high-risk types, was observed at 6 months (relative risk [RR], 3.3; 95% confidence interval [CI], 2.04 to 5.30; p < 0.001) and 12 months (RR, 5.03; 95% CI, 2.56 to 9.91; p < 0.001).
Conclusion
HPV genotypes numbered in the 50s were frequent in Korean women with ASC-US and LSIL. HPV 58 was the second most common type, with a high progression rate of cervical cytology.

Citations

Citations to this article as recorded by

Women 50 Years and Older With Negative Pap Test and Positive Human Papillomavirus Test for Genotypes Other Than 16 and 18—Follow-up Outcomes
Farah S. Baban, Michael R. Henry, Margaret E. Long, Meredith A. VandeHaar, Grant M. Spears, Sarah M. Jenkins, Diva R. Salomao
Journal of Lower Genital Tract Disease.2024; 28(1): 43. CrossRef
Cervical intraepithelial neoplasia in non-16/18 high-risk human papilloma virus positive/cytology negative women: An alternative approach in poor resource areas
Fariba Yarandi, Elham Shirali, Elham Feizabad, Sara Ramhormoziyan, Soheila Sarmadi, Maryam SadrAmeli, Elham Arshadi
Taiwanese Journal of Obstetrics and Gynecology.2023; 62(2): 299. CrossRef
Molecular markers predicting the progression and prognosis of human papillomavirus-induced cervical lesions to cervical cancer
Fatema Alzahraa Samy Amin, Zeba Un Naher, P. Shaik Syed Ali
Journal of Cancer Research and Clinical Oncology.2023; 149(10): 8077. CrossRef
Herpes Simplex Virus, Human Papillomavirus, and Cervical Cancer: Overview, Relationship, and Treatment Implications
Daniel Sausen, Oren Shechter, Elisa Gallo, Harel Dahari, Ronen Borenstein
Cancers.2023; 15(14): 3692. CrossRef
Association strength of E6 to E6AP/p53 complex correlates with HPV‐mediated oncogenesis risk
Matheus Vitor Ferreira Ferraz, Isabelle Freire Tabosa Viana, Danilo Fernandes Coêlho, Carlos Henrique Bezerra da Cruz, Maíra de Arruda Lima, Madson Allan de Luna Aragão, Roberto Dias Lins
Biopolymers.2022;[Epub] CrossRef
Diagnostic performance of immediate colposcopy among women with high‐risk human papillomavirus (HPV) other than HPV 16/18 and normal cytology
Serdar Aydın, Hande Nur Öncü, Dilek Sema Arıcı
Journal of Obstetrics and Gynaecology Research.2021; 47(2): 720. CrossRef
Mixed and nonvaccine high risk HPV types are associated with higher mortality in Black women with cervical cancer
Rachelle P. Mendoza, Tahmineh Haidary, Elmer Gabutan, Ying Yin Zhou, Zaheer Bukhari, Courtney Connelly, Wen-Ching Lee, Yi-Chun Lee, Raj Wadgaonkar, Raag Agrawal, M. A. Haseeb, Raavi Gupta
Scientific Reports.2021;[Epub] CrossRef
Distribution of HPV genotypes among women with abnormal cytology results in Alberta, Canada
Sabrina S Plitt, Ryan Kichuk, Sheena Geier, Trenton Smith, Felicia Roy, Alberto Severini, Carmen L Charlton
Journal of the Association of Medical Microbiology and Infectious Disease Canada.2021; 6(2): 94. CrossRef
The Clinical Significance and Utility of HPV-DNA Testing in Korean Women with Atypical Glandular Cells in Cervical Pap Tests: An Analysis of 311 Cases at a Single Institution
Tae-Kyu Jang, Jeong-Yeol Park, Dae-Yeon Kim, Dae-Shik Suh, Jong-Hyeok Kim, Yong-Man Kim, Young-Tak Kim, Joo-Hyun Nam
Cancer Investigation.2021; 39(10): 885. CrossRef
Enhanced disease progression due to persistent HPV-16/58 infections in Korean women: a systematic review and the Korea HPV cohort study
Jaehyun Seong, Sangmi Ryou, JeongGyu Lee, Myeongsu Yoo, Sooyoung Hur, Byeong-Sun Choi
Virology Journal.2021;[Epub] CrossRef
Risk of cervical lesions in high-risk HPV positive women with normal cytology: a retrospective single-center study in China
Zhiling Wang, Ting Liu, Yunjian Wang, Ying Gu, Hui Wang, Jingkang Liu, Baoxia Cui, Xingsheng Yang
Infectious Agents and Cancer.2020;[Epub] CrossRef
Co-infection between genotypes of the human papillomavirus and Chlamydia trachomatis in Mexican women
Marco A Escarcega-Tame, Marcela López-Hurtado, Marcos R Escobedo-Guerra, Elba Reyes-Maldonado, Graciela Castro-Escarpulli, Fernando M Guerra-Infante
International Journal of STD & AIDS.2020; 31(13): 1255. CrossRef
Artificial intelligence estimates the impact of human papillomavirus types in influencing the risk of cervical dysplasia recurrence: progress toward a more personalized approach
Giorgio Bogani, Antonino Ditto, Fabio Martinelli, Mauro Signorelli, Valentina Chiappa, Umberto Leone Roberti Maggiore, Francesca Taverna, Claudia Lombardo, Chiara Borghi, Cono Scaffa, Domenica Lorusso, Francesco Raspagliesi
European Journal of Cancer Prevention.2019; 28(2): 81. CrossRef
Human papillomavirus genotype-specific risk in cervical carcinogenesis
Kyeong A So, In Ho Lee, Ki Heon Lee, Sung Ran Hong, Young Jun Kim, Hyun Hee Seo, Tae Jin Kim
Journal of Gynecologic Oncology.2019;[Epub] CrossRef
Comparison of the PANArray HPV Genotyping Chip Test with the Cobas 4800 HPV and Hybrid Capture 2 Tests for Detection of HPV in ASCUS Women
Eun Young Ki, Yoon Kyung Lee, Ahwon Lee, Jong Sup Park
Yonsei Medical Journal.2018; 59(5): 662. CrossRef
Genetic variability in E6, E7 and L1 genes of Human Papillomavirus 62 and its prevalence in Mexico
Cristina Artaza-Irigaray, María Guadalupe Flores-Miramontes, Dominik Olszewski, María Teresa Magaña-Torres, María Guadalupe López-Cardona, Yelda Aurora Leal-Herrera, Patricia Piña-Sánchez, Luis Felipe Jave-Suárez, Adriana Aguilar-Lemarroy
Infectious Agents and Cancer.2017;[Epub] CrossRef

33,962 View
301 Download
16 Web of Science
16 Crossref

Case Reports

Hepatocellular Carcinoma Presenting as Uterine Metastasis: Woo Dae Kang, Cheol Hong Kim, Moon Kyung Cho, Jong Woon Kim, Ji Shin Lee, Yoon Ha Kim, Ho Sun Choi, Seok Mo Kim; Cancer Res Treat. 2008;40(3):141-144. Published online September 30, 2008; DOI: https://doi.org/10.4143/crt.2008.40.3.141

Abstract PDF PubReader ePub

Metastatic extragenital cancer that spreads to the uterus is rare. When it occurs, the extragenital primary disease is often in the breast or gastrointestinal tract. We report here on a case of hepatocellular carcinoma (HCC) that metastasis to the uterus. The patient was admitted for evaluation of a pelvic mass. The serum alpha-fetoprotein level was highly elevated. Magnetic resonance imaging of the abdomen and pelvis showed hepatic and uterine masses. The patient underwent surgical treatment. The histopathologic findings and immunohistochemical staining results of the uterine mass were char acteristics of metastatic HCC. The endometrium and both ovaries were free of tumor. Up to now, there have been only two cases of uterine metastasis from HCC reported in the English literature. This case is the first documented instance of a metastatic uterine tumor from HCC that spared both ovaries.

Citations

Citations to this article as recorded by

Pelvis metastasis with rectal infiltration in hepatocellular carcinoma - a rare case report
Arnetta Naomi Louise Lalisang, Davin Nathan Wijaya, Indah Jamtani, Vania Myralda Giamour Marbun, Yarman Mazni, Toar Jean Maurice Lalisang, Marini Stephanie, Taufik Agung Wibowo
European Journal of Medical Case Reports.2024;[Epub] CrossRef
Pelvis metastasis with rectal infiltration in hepatocellular carcinoma - a rare case report
Arnetta Naomi Louise Lalisang, Davin Nathan Wijaya, Indah Jamtani, Vania Myralda Giamour Marbun, Yarman Mazni, Toar Jean Maurice Lalisang, Marini Stephanie, Taufik Agung Wibowo
European Journal of Medical Case Reports.2024;[Epub] CrossRef
Rare Site Hepatocellular Carcinoma Metastasis

Enrique Boldo, Ana Santafe, Araceli Mayol, Rafael Lozoya, Alba Coret, Diana Escribano, Carlos Fortea, Andres Muñoz, Juan Carlos Pastor, Guillermo Pérez de Lucia, Nuria Bosch Aparicio
Journal of Hepatocellular Carcinoma.2020; Volume 7: 39. CrossRef
Cholangiocarcinoma Presenting as Uterine Metastasis
W. Dendas, L. Cappelle, J. Verguts, G. Orye
Case Reports in Obstetrics and Gynecology.2014; 2014: 1. CrossRef
Localized Uterine Recurrence of Hepatocellular Carcinoma 4 Years after Curative Resection
Sang Jin Lee, Jung Woo Shin, Neung Hwa Park, Yang Won Nah, Hang Jo Yoo, Yoong Ki Jung, Hye Jeong Choi
Korean Journal of Medicine.2012; 82(5): 603. CrossRef
Endometrial Carcinomas
Carla Bartosch, José Manuel Lopes, Esther Oliva
Advances in Anatomic Pathology.2011; 18(6): 415. CrossRef

8,528 View
67 Download
6 Crossref

Primary Epithelial Ovarian Carcinoma with Gastric Metastasis Mimic Gastrointestinal Stromal Tumor: Woo Dae Kang, Cheol Hong Kim, Moon Kyoung Cho, Jong Woon Kim, Ji Shin Lee, Seong Yeob Ryu, Yoon Ha Kim, Ho Sun Choi, Seok Mo Kim; Cancer Res Treat. 2008;40(2):93-96. Published online June 30, 2008; DOI: https://doi.org/10.4143/crt.2008.40.2.93

Abstract PDF PubReader ePub

Epithelial ovarian carcinoma rarely metastasizes to the parenchyma of the stomach. A 55-years-old woman presented with epigastric pain and a feeling of fullness for one month. A subsequent contrast-enhanced CT scan demonstrated a 4.5×4 cm submucosal mass with focal ulceration in the gastric antrum, and this finding was suggestive of GIST. After gastric antrectomy, the final pathology showed metastatic gastric tumor from a primary ovarian serous carcinoma. Because epithelial ovarian carcinoma is usually spread along the peritoneal surface, stomach involvement is rare. Furthermore, transmural gastric metastasis is very rare in a patient with primary ovarian carcinoma. Until now, there has been no reported case of stomach involvement at presentation in a patient with primary ovarian carcinoma. We present here a case of ovarian carcinoma with gastric metastasis that mimicked GIST.

Citations

Citations to this article as recorded by

Ovarian serous carcinoma with stomach metastasis: a rare case report and literature review
Jia-Li Hu, Zhao-Jiao Guo, Chun Wang, Jun Yan, Hao Yang
Journal of International Medical Research.2024;[Epub] CrossRef
Gastrointestinal Stromal Tumors (GISTs) Mimicking Primary Ovarian Tumors or Metastasizing to the Ovaries: A Systematic Literature Review
Gabriele Tonni, Andrea Palicelli, Maria Bassi, Federica Torricelli, Ilaria Vacca, Lorenzo Aguzzoli, Vincenzo Mandato
Cancers.2024; 16(13): 2305. CrossRef
Solitary Gastric Metastasis from a Stage IA Serous Ovarian Carcinoma: A Case Report with Literature Review
Keishi Mizuguchi, Hiroshi Minato, Isao Yoshida, Junpei Iwadare, Kayo Kayahashi, Yuki Mitani, Kazuyoshi Watanabe
Internal Medicine.2017; 56(8): 915. CrossRef
Isolated gastric recurrence from ovarian carcinoma: A case report
QIAN LIU, QIAN-QIAN YU, HAO WU, ZHI-HONG ZHANG, REN-HUA GUO
Oncology Letters.2015; 9(3): 1173. CrossRef
Improved Survival of a Patient with Gastric and Other Multiple Metastases from Ovarian Cancer by Multimodal Treatment: A Case Report
Seonmi Hwangbo, Oh Kyoung Kwon, Ho Young Chung, Wansik Yu
Journal of Gastric Cancer.2015; 15(3): 218. CrossRef
Clinicopathological features and treatment outcomes of metastatic tumors in the stomach
Tsutomu Namikawa, Kazuhiro Hanazaki
Surgery Today.2014; 44(8): 1392. CrossRef
Gastric Metastasis from Ovarian Cancer Presenting as a Submucosal Tumor: A Case Report
Eun Young Kim, Cho Hyun Park, Eun Sun Jung, Kyo Young Song
Journal of Gastric Cancer.2014; 14(2): 138. CrossRef
Gastric perforation secondary to metastasis from ovarian cancer: Case report
Firas Obeidat, Ayman Mismar, Maha Shomaf, Mohammad Yousef, Kamil Fram
International Journal of Surgery Case Reports.2013; 4(6): 541. CrossRef
Multiple Gastric Metastases from Ovarian Carcinoma Diagnosed by Endoscopic Ultrasound with Fine Needle Aspiration
Mehmet Akce, Sharon Bihlmeyer, Andrew Catanzaro
Case Reports in Gastrointestinal Medicine.2012; 2012: 1. CrossRef
Gastric metastasis from ovarian carcinoma diagnosed by EUS-FNA biopsy and elastography
Silvia Carrara, Claudio Doglioni, Paolo Giorgio Arcidiacono, Pier Alberto Testoni
Gastrointestinal Endoscopy.2011; 74(1): 223. CrossRef

11,390 View
69 Download
10 Crossref

Original Articles

Hydrogen Peroxide Producing Lactobacilli in Women with Cervical Neoplasia: Ho Sun Choi, Ki Min Kim, Chol Hong Kim, Seok Mo Kim, Jong Seok Oh; Cancer Res Treat. 2006;38(2):108-111. Published online April 30, 2006; DOI: https://doi.org/10.4143/crt.2006.38.2.108

Abstract PDF PubReader ePub

Purpose

It is well known that human papillomavirus (HPV) is the main cause of cervical neoplasia, and hydrogen peroxide-producing lactobacilli are the most important microorganisms for maintaining the balance of the vaginal ecosystem. The purpose of our study was to investigate the relationship of hydrogen peroxide-producing lactobacilli, cervical neoplasia and high-risk HPV.

Materials and Methods

We enrolled 1138 women with abnormal cervical smears or cervicograms who were referred to the department of Obstetrics and Gynecology at Chonnam National University Medical School. In all of them, 1,138 vaginal swabs were collected for the qualitative assay of hydrogen peroxide producing lactobacilli and 150 cervical swabs were used for the HPV hybrid capture II test without regard to the subjects' pregnancy status. In the non-pregnant women, 880 cervical biopsies and/or loop electrosurgical excision procedures were performed for making the histological diagnosis.

Results

There was no significant difference not only between the distribution of H₂O₂ producing lactobacilli and the cervical histology, but also between the distribution of H₂O₂ producing lactobacilli and the positivity for high-risk HPV.

Conclusions

Both cervical neoplasia and high-risk HPV may not be influenced by the existence of hydrogen peroxide producing lactobacilli in the vagina.

Citations

Citations to this article as recorded by

Unravelling the Biological Interplay Between Genital HPV Infection and Cervicovaginal Microbiota in Sub-Saharan Africa: Implications for Cervical (Pre)cancer Prevention
Harris Onywera, Zizipho Z. A. Mbulawa, Adrian Brink, Anna-Lise Williamson, Lamech M. Mwapagha
Venereology.2024; 3(4): 211. CrossRef
Antimicrobial activity of Lactobacillus against microbial flora of cervicovaginal infections
Subramanyam Dasari, Raju Naidu Devanaboyaina Shouri, Rajendra Wudayagiri, Lokanatha Valluru
Asian Pacific Journal of Tropical Disease.2014; 4(1): 18. CrossRef
PCR‐based identification of eight lactobacillus species and 18 hr‐HPV genotypes in fixed cervical samples of south african women at risk of HIV and BV
Joke A.M. Dols, Gregor Reid, Remco Kort, Frank H.J. Schuren, Hugo Tempelman, Tj. Romke Bontekoe, Hans Korporaal, E.M. Van der Veer, Pieter W. Smit, Mathilde E. Boon
Diagnostic Cytopathology.2012; 40(6): 472. CrossRef

9,436 View
80 Download
3 Crossref

The Clinical Values of Metaplasia, p 53, c - erbB2 and CEA Expression in Gallbladder Carcinoma: Seok Mo Kim, Seong Hwan Kim, Jeong Hwan Chang, Sung chul Lim, Chae Hong Suh; J Korean Cancer Assoc. 1999;31(6):1261-1270.

Abstract PDF: PURPOSE
We evaluated the correlation between the carcinogenesis of gallbladder and the expression of lysozyme, p53, c-erbB2 and CEA in gallbladder lesions.
MATERIALS AND METHODS
Thirty cases of gallbladder lesions (containing 17 cases of GB carcinoma) were examined. We analyzed the clinicopathologic findings of the early (stage I & II) and advanced carcinoma (stage III, IV & V) and those of carcinoma with or without metaplasia in the tumor. We performed p53, c-erbB2 and CEA immunohistochemical staining and compared their findings with those of normal mucosa and preneoplastic lesions. We also performed lysozyme immunohistochemical staining and compared its finding with metaplastic and non-metaplastic lesions.
RESULTS
There are two distinct genetic pathways in gallbladder cacinogenesis and metaplastic carcinoma was more frequent than non-metaplastic carcinoma. Metaplasia of gallbladder did not reveal any difference of the clinicopathologic findings and depth of invasion (Nevin stage). Lysozyme expression was found in all metaplastic lesions but non-expression did not indicate non-metaplastic lesions. p53 mutations and c-erbB2 alterations may have a role in the carcinogenesis of gallbladder carcinomas, especially, in a late event, and in an early and late events, respectively. The correlation of p53 and c-erbB2 expressions was found but which did not indicate that the co-expression was needed in the carcinogenesis. CEA immunohistochemical staining may be helpful in the differential diagnosis of benign lesions and precancerous and cancerous lesions of the gallbladder.
CONCLUSION
These results suggest that p53 mutations and c-erbB2 alterations may have a role in the carcinogenesis of gallbladder carcinomas, especially, in a late event, and in an early and late events, respectively.

2,447 View
15 Download

First
Prev
Page of 1
Next
Last

Search