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2 "Semin Cho"
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Lung Cancer
Clinical Significance of Acute Kidney Injury in Lung Cancer Patients
Semin Cho, Eunjeong Kang, Ji Eun Kim, U Kang, Hee Gyung Kang, Minsu Park, Kwangsoo Kim, Dong Ki Kim, Kwon Wook Joo, Yon Su Kim, Hyung-Jin Yoon, Hajeong Lee
Cancer Res Treat. 2021;53(4):1015-1023.   Published online January 18, 2021
DOI: https://doi.org/10.4143/crt.2020.1010
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
Acute kidney injury (AKI) in cancer patients is associated with increased morbidity and mortality. The incidence of AKI in lung cancer seems to be relatively higher compared with other solid organ malignancies, although its impact on patient outcomes remains unclear.
Materials and Methods
The patients newly diagnosed with lung cancer from 2004 to 2013 were enrolled in this retrospective cohort study. The patients were categorized according to the presence and severity of AKI. We compared all-cause mortality and long-term renal outcome according to AKI stage.
Results
A total of 3,202 patients were included in the final analysis. AKI occurred in 1,783 (55.7%) patients during the follow-up period, with the majority having mild AKI stage 1 (75.8%). During the follow-up of 2.6±2.2 years, total 1,251 patients (53.7%) were died and 5-year survival rate was 46.9%. We found that both AKI development and severity were independent risk factors for all-cause mortality in lung cancer patients, even after adjustment for lung cancer-specific variables including the stage or pathological type. In addition, patients suffered from more severe AKI tend to encounter de novo chronic kidney disease development, worsening kidney function, and end-stage kidney disease progression.
Conclusion
In this study, more than half of the lung cancer patients experienced AKI during their diagnosis and treatment period. Moreover, AKI occurrence and more advanced AKI were associated with a higher mortality risk and adverse kidney outcomes.

Citations

Citations to this article as recorded by  
  • Acute kidney injury associated with anti-PD-1 and anti-PD-L1 drugs: a meta-analysis of randomized clinical trials
    Isabela Gonçalves Lima, Isabele Benck Usiro Cabral da Silva, Vitória Carpentieri Pípolo, Vinicius Daher Alvares Delfino, Paulo Roberto Bignardi
    Immunopharmacology and Immunotoxicology.2024; 46(4): 470.     CrossRef
  • Prevalence of kidney disease in patients with different types of cancer or hematological malignancies: a cross-sectional study
    Feng Wu, Shiyuan Wang, Jialing Zhang, Peixin Wang, Aihua Zhang
    International Urology and Nephrology.2024; 56(12): 3835.     CrossRef
  • Protective effect of reduced glutathione on acute kidney injury in lung cancer patients treated with cisplatin: a retrospective cohort study
    Ying Huang, Yang Li, Xialian Xu, Jie Teng, Xiaoqiang Ding, Jiarui Xu
    Renal Failure.2024;[Epub]     CrossRef
  • Association between renal dysfunction and outcomes of lung cancer: A systematic review and meta‑analysis
    Huijuan Qian, Si Li, Ziyun Hu
    Oncology Letters.2024;[Epub]     CrossRef
  • Association and prediction of red blood cell distribution width to albumin ratio in all-cause mortality of acute kidney injury in critically ill patients
    Chen Gao, Longkai Peng
    Frontiers in Medicine.2023;[Epub]     CrossRef
  • Point of care ultrasonography in onco-nephrology: A stride toward better physical examination
    Bhavna Bhasin-Chhabra, Abhilash Koratala
    World Journal of Nephrology.2023; 12(2): 29.     CrossRef
  • Protocolo diagnóstico y tratamiento de la nefropatía en los pacientes con neoplasia sólida
    Rodríguez Doyágüez, M.P. Morán Magro, C.M. Durán López, P. Martínez Miguel
    Medicine - Programa de Formación Médica Continuada Acreditado.2023; 13(82): 4870.     CrossRef
  • 7,316 View
  • 193 Download
  • 6 Web of Science
  • 7 Crossref
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Evaluation of Diagnostic Performance of Screening Thyroid Ultrasonography and Imaging Findings of Screening-Detected Thyroid Cancer
Jeongin Yoo, Hye Shin Ahn, Soo Jin Kim, Sung Hee Park, Mirinae Seo, Semin Chong
Cancer Res Treat. 2018;50(1):11-18.   Published online February 24, 2017
DOI: https://doi.org/10.4143/crt.2016.600
AbstractAbstract PDFPubReaderePub
Purpose
The purpose of this study was to evaluate the diagnostic performance and cost of screening thyroid ultrasonography (US) in an asymptomatic population and determine the US features of screening-detected thyroid cancer.
Materials and Methods
This study included 1,845 asymptomatic participants who underwent screening thyroid US between March and August 2012 at the screening center in our hospital. We evaluated the diagnostic performance of screening thyroid US for thyroid cancer and the average cost of diagnosis for each patient. We also determined the characteristic US features of screening-detected thyroid cancer.
Results
Of the 1,845 subjects, 661 showed no abnormalities, 1,155 exhibited benign thyroid nodules, and 29 exhibited thyroid cancer. Imaging features such as solid composition, hypoechogenicity, taller-than-wide axis, and ill-defined or spiculated margins of nodules were suggestive of malignancy. The rate of detection of cancer was 1.6% (29/1,845), and the sensitivity, specificity, and positive and negative predictive values were 100% (18/18), 98.7% (1,051/1,065), 56.3% (18/32), and 100% (1,051/1,051), respectively. Of 18 patients who underwent thyroidectomy, three (16.7%) had a pathological tumor staging of T3, and four (22.2%) had a pathological nodal staging of N1a. The average cost of diagnosis for each patient with cancer was $7,319.
Conclusion
Screening thyroid US exhibited a good diagnostic performance, with a feasible social cost of use. This modality demonstrated significant differences in sonographic features between screening-detected cancer and benign nodules.

Citations

Citations to this article as recorded by  
  • Temporal Trends in Thyroid Nodule Size on Ultrasonography
    Hayley Mann, Natalia Arroyo, Vivian Hsiao, Franklin Tessler, Lori Mankowski Gettle, Yanchen Zhang, Abdullah Adil, Mary Hitchcock, Elian Massoud, Catherine Jensen, Oguzhan Alagoz, Louise Davies, Sara Fernandes-Taylor, David O. Francis
    JAMA Otolaryngology–Head & Neck Surgery.2025; 151(1): 47.     CrossRef
  • A nomogram based on clinicopathological and ultrasound characteristics to predict central neck lymph node metastases in papillary thyroid cancer
    Fei Chen, Shuiping Jiang, Fan Yao, Yixi Huang, Jiaxi Cai, Jia Wei, Chengxu Li, Yanxuan Wu, Xiaolin Yi, Zhen Zhang
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Comparison of the value of ultrasound-guided fine needle aspiration biopsy and contrast-enhanced ultrasound in different sizes of thyroid nodules
    Qi Liu, Liquan Ouyang, Shengchu Zhang, Yuxia Yang
    Medicine.2024; 103(39): e39843.     CrossRef
  • Thyroid Ultrasonography Screening of a Cohort of Male University Students
    Mahmoud S. Babiker, Fathelrehman A. Alamin, Mohammed Almteri, Abdullah Alradaddi, Waleed Alharbi
    Journal of Diagnostic Medical Sonography.2024;[Epub]     CrossRef
  • Diagnostic performance of six ultrasound-based risk stratification systems in thyroid follicular neoplasm: A retrospective multi-center study
    Jingjing Yang, Yu Sun, Xingjia Li, Yueting Zhao, Xue Han, Guofang Chen, Wenbo Ding, Ruiping Li, Jianhua Wang, Fangsen Xiao, Chao Liu, Shuhang Xu
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Clinical and ultrasonography evaluation of thyroid tumor screening in symptomatic patient of Bajulmati primary care center, Banyuwangi, East Java, Indonesia
    Rosy Setiawati, Tri Wulanhandarini, Fierly Hayati, Dyah Erawati, Merlin Guntur Jaya, Andi Ahmad Thoriq, Triana Mediyawati Wijaya, Galih Nur Ismiyati, Dyan Wahyu Kusumaningrum, Belinda Koesmarsono, Agnes Triana Basja, M. Ikhsan Nugroho, Silvi Yuliana, Syad
    Medicine.2022; 101(52): e32546.     CrossRef
  • The use of computed tomography as a first-line imaging modality in patients with primary hyperparathyroidism
    Mechteld C. de Jong, K. Jamal, S. Morley, T. Beale, T. Chung, S. Jawad, S. Hurel, H. Simpson, U. Srirangalingam, S. E. Baldeweg, V. Rozalén García, S. Otero, M. Shawky, T. E. Abdel-Aziz, T. R. Kurzawinski
    Hormones.2021; 20(3): 499.     CrossRef
  • Sex Bias in Differentiated Thyroid Cancer
    Valentine Suteau, Mathilde Munier, Claire Briet, Patrice Rodien
    International Journal of Molecular Sciences.2021; 22(23): 12992.     CrossRef
  • Hashimoto Thyroiditis in Primary Thyroid Non-Hodgkin Lymphoma
    Antonio Travaglino, Mirella Pace, Silvia Varricchio, Luigi Insabato, Claudia Giordano, Marco Picardi, Fabrizio Pane, Stefania Staibano, Massimo Mascolo
    American Journal of Clinical Pathology.2020; 153(2): 156.     CrossRef
  • Changes in the Diagnostic Efficiency of Thyroid Fine-Needle Aspiration Biopsy during the Era of Increased Thyroid Cancer Screening in Korea
    Young Ki Lee, Kyeong Hye Park, Young Duk Song, Taemi Youk, Joo Young Nam, Sun Ok Song, Dong Yeob Shin, Eun Jig Lee
    Cancer Research and Treatment.2019; 51(4): 1430.     CrossRef
  • Sonographic Criteria Predictive of Malignant Thyroid Nodules
    Carlos Miguel Oliveira, Rui Alves Costa, Miguel Patrício, Amélia Estêvão, Bruno Graça, Filipe Caseiro-Alves
    Academic Radiology.2017;[Epub]     CrossRef
  • 11,305 View
  • 294 Download
  • 14 Web of Science
  • 11 Crossref
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