Skip Navigation
Skip to contents

Cancer Res Treat : Cancer Research and Treatment

Search
Advanced Search
OPEN ACCESS
mobile search button mobile menu button

Search

Page Path
HOME > Search
2 "Sarah Yang"
Filter
Filter
Article category
Keywords
More +
Publication year
Authors
More +
Funded articles
Original Articles
Genome-Wide Association of Genetic Variation in the PSCA Gene with Gastric Cancer Susceptibility in a Korean Population
Boyoung Park, Sarah Yang, Jeonghee Lee, Hae Dong Woo, Il Ju Choi, Young Woo Kim, Keun Won Ryu, Young-Il Kim, Jeongseon Kim
Cancer Res Treat. 2019;51(2):748-757.   Published online September 5, 2018
DOI: https://doi.org/10.4143/crt.2018.162
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
Half of the world’s gastric cancer cases and the highest gastric cancer mortality rates are observed in Eastern Asia. Although several genome-wide association studies (GWASs) have revealed susceptibility genes associated with gastric cancer, no GWASs have been conducted in the Korean population, which has the highest incidence of gastric cancer.
Materials and Methods
We performed genome scanning of 450 gastric cancer cases and 1,134 controls via Affymetrix Axiom Exome 319 arrays, followed by replication of 803 gastric cancer cases and 3,693 healthy controls.
Results
We showed that the rs2976394 in the prostate stem cell antigen (PSCA) gene is a gastriccancer-susceptibility gene in a Korean population, with genome-wide significance and an odds ratio (OR) of 0.70 (95% confidence interval [CI], 0.64 to 0.77). A strong linkage disequilibrium with rs2294008 was also found, indicating an association with susceptibility. Individuals with the CC genotype of the PSCA gene showed an approximately 2-fold lower risk of gastric cancer compared to those with the TT genotype (OR, 0.47; 95% CI, 0.39 to 0.57). The effect of the PSCA gene on gastric cancer was more prominent in the female population and for diffuse type gastric cancer.
Conclusion
Our result confirmed that the PSCA gene may be the most important susceptibility gene for gastric cancer risk in a Korean population.

Citations

Citations to this article as recorded by  
  • Functional Annotation and Gene Set Analysis of Gastric Cancer Risk Loci in a Korean Population
    Hyojin Pyun, Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Joohon Sung, Jeongseon Kim
    Cancer Research and Treatment.2024; 56(1): 191.     CrossRef
  • HiChIP-Based Epigenomic Footprinting Identifies a Promoter Variant of UXS1 That Confers Genetic Susceptibility to Gastroesophageal Cancer
    Ansley Gnanapragasam, Eftyhios Kirbizakis, Anna Li, Kyle H. White, Katelyn L. Mortenson, Juliana Cavalcante de Moura, Wajih Jawhar, Yifei Yan, Reilly Falter, Colleen Russett, Betty Giannias, Sophie Camilleri-Broët, Nicholas Bertos, Jonathan Cools-Lartigue
    Cancer Research.2024; 84(14): 2377.     CrossRef
  • High Polygenic Risk Scores Positively Associated with Gastric Cancer Risk Interact with Coffee and Polyphenol Intake and Smoking Status in Korean Adults
    Meiling Liu, Sang-Shin Song, Sunmin Park
    Nutrients.2024; 16(19): 3263.     CrossRef
  • Dietary mercury intake, the IL23R rs10889677 polymorphism, and the risk of gastric cancer in a Korean population: a hospital-based case-control study
    Ji Hyun Kim, Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jeongseon Kim
    Epidemiology and Health.2024; 46: e2024051.     CrossRef
  • SNP-SNP Interactions and Gastric Cancer Susceptibility in Ardabil Province
    Homa Akhavan Aghghaleh, Najmeh Ranji, Hadi Habibollahi
    Journal of Ardabil University of Medical Sciences.2024; 24(3): 364.     CrossRef
  • Interaction between dietary potassium intake and TNF-α rs1800629 genetic polymorphism in gastric cancer risk: a case–control study conducted in Korea
    Tao Thi Tran, Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jeongseon Kim
    British Journal of Nutrition.2023; 130(5): 887.     CrossRef
  • Rare variants confer shared susceptibility to gastrointestinal tract cancer risk
    Ji Zheng, Xin Wang, Jingrao Li, Yuanna Wu, Jiang Chang, Junyi Xin, Meilin Wang, Tianpei Wang, Qingyi Wei, Mengyun Wang, Ruoxin Zhang
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • The association of dietary fibre intake and the IL13 rs20541 polymorphism with the risk of gastric cancer: a case-control study in Korea
    Tao Thi Tran, Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jeongseon Kim
    European Journal of Clinical Nutrition.2022; 76(7): 1031.     CrossRef
  • Systematic review of gastric cancer-associated genetic variants, gene-based meta-analysis, and gene-level functional analysis to identify candidate genes for drug development
    Sangjun Lee, Han-Kwang Yang, Hyuk-Joon Lee, Do Joong Park, Seong-Ho Kong, Sue K. Park
    Frontiers in Genetics.2022;[Epub]     CrossRef
  • Incidence of Hereditary Gastric Cancer May Be Much Higher than Reported
    Paula Baraúna de Assumpção, Paulo Pimentel de Assumpção, Fabiano Cordeiro Moreira, Ândrea Ribeiro-dos-Santos, Amanda F. Vidal, Leandro Magalhães, André Salim Khayat, André Maurício Ribeiro-dos-Santos, Giovanna C. Cavalcante, Adenilson Leão Pereira, Inácio
    Cancers.2022; 14(24): 6125.     CrossRef
  • Enhancing the Trajectories of Cancer Health Disparities Research: Improving Clinical Applications of Diversity, Equity, Inclusion, and Accessibility
    Rachel Martini, Endale Gebregzabher, Lisa Newman, Melissa B. Davis
    Cancer Discovery.2022; 12(6): 1428.     CrossRef
  • Identification of Novel Susceptible Genes of Gastric Cancer Based on Integrated Omics Data
    Huang Yaoxing, Yu Danchun, Sun Xiaojuan, Jiang Shuman, Yan Qingqing, Jia Lin
    Frontiers in Cell and Developmental Biology.2021;[Epub]     CrossRef
  • The Associations of Dietary Iron Intake and the Transferrin Receptor (TFRC) rs9846149 Polymorphism with the Risk of Gastric Cancer: A Case–Control Study Conducted in Korea
    Tao Thi Tran, Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jeongseon Kim
    Nutrients.2021; 13(8): 2600.     CrossRef
  • Integration of GWAS and eQTL Analysis to Identify Risk Loci and Susceptibility Genes for Gastric Cancer
    Jing Ni, Bin Deng, Meng Zhu, Yuzhuo Wang, Caiwang Yan, Tianpei Wang, Yaqian Liu, Gang Li, Yanbing Ding, Guangfu Jin
    Frontiers in Genetics.2020;[Epub]     CrossRef
  • Evolutionary History of the Risk of SNPs for Diffuse-Type Gastric Cancer in the Japanese Population
    Risa L. Iwasaki, Koji Ishiya, Hideaki Kanzawa-Kiriyama, Yosuke Kawai, Jun Gojobori, Yoko Satta
    Genes.2020; 11(7): 775.     CrossRef
  • TNF genetic polymorphism (rs1799964) may modify the effect of the dietary inflammatory index on gastric cancer in a case–control study
    Jeeeun Kim, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Joohon Sung, Jeongseon Kim
    Scientific Reports.2020;[Epub]     CrossRef
  • Prediction of gastric cancer risk: association between ZBTB20 genetic variance and gastric cancer risk in Chinese Han population
    Fei Bai, Ke Xiao
    Bioscience Reports.2020;[Epub]     CrossRef
  • Incidence of Stomach and Esophageal Cancers in Mongolia: Data from 2009 to 2018
    Tsegmed Sambuu, Nasanjargal Tumurbat, Bayar Davaa, Bolor-Erdene Tudev
    Euroasian Journal of Hepato-Gastroenterology.2020; 10(1): 16.     CrossRef
  • 10,442 View
  • 209 Download
  • 16 Web of Science
  • 18 Crossref
Close layer
Effects of Soy Product Intake and Interleukin Genetic Polymorphisms on Early Gastric Cancer Risk in Korea: A Case-Control Study
Sarah Yang, Yoon Park, Jeonghee Lee, Il Ju Choi, Young Woo Kim, Keun Won Ryu, Joohon Sung, Jeongseon Kim
Cancer Res Treat. 2017;49(4):1044-1056.   Published online January 19, 2017
DOI: https://doi.org/10.4143/crt.2016.515
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
The current study investigated whether the combined effects of soy intake and genetic polymorphisms of interleukin (IL) genes modify gastric cancer risk.
Materials and Methods
A total of 377 cases and 754 controls of Korean origin were included in the analysis. Soy consumption was assessed using a semi-quantitative food frequency questionnaire. Seven variants of IL10 (rs1800871), IL2 (rs2069763 and rs2069762), IL13 (rs6596090 and rs20541), and IL4R(rs7205663 and rs1805010) were genetically analyzed. To analyze the combined effect of soy intake and genetic polymorphisms, a low-intake group and high-intake group of each type of soy were categorized based on the intake level of the control group. Interactions between soy products and these genetic variants were analyzed by a likelihood ratio test, in which a multiplicative interaction term was added to the logistic regression model.
Results
A higher intake of nonfermented soy products was associated with a reduced cancer risk (odds ratio [OR], 0.62; 95% confidence interval [CI], 0.43 to 0.90), and the reduced risk was only apparent in males (OR, 0.44; 95% CI, 0.27 to 0.71). None of the IL genetic polymorphisms examined were independently associated with gastric cancer risk. Individuals with a minor allele of IL2 rs2069762 and a higher intake of nonfermented soy food had a decreased risk of gastric cancer (OR, 0.46; 95% CI, 0.31 to 0.68) compared to those with a lower intake (pinteraction=0.039).
Conclusion
Based on the genetic characteristics of the studied individuals, the interaction between IL2 rs2069762 and nonfermented soy intake may modify the risk of gastric cancer.

Citations

Citations to this article as recorded by  
  • Polyphenol intake and gastric cancer: A case-control study in the Brazilian Amazon region
    Marcela de Araújo Fagundes, Renata Alves Carnauba, Gisele Aparecida Fernandes, Paulo Pimentel de Assumpção, Maria Paula Curado
    Cancer Epidemiology.2024; 88: 102518.     CrossRef
  • Oral Microbiota as a Diagnostic Biomarker of Digestive Cancer: A Systematic Review
    SK Aziz Ikbal, Surendra Kumar Yadav, Roopanshi Mehrotra, Tasneem Fatima, Anjusha Sharda, Srashti Gupta
    The Journal of Contemporary Dental Practice.2024; 24(11): 902.     CrossRef
  • The pertinence of gastric cancer and interleukin 10–819 single nucleotide polymorphisms: a meta-analysis and systematic review
    Qianqian Mao, Yanwen Liu, Xi Chen, Cheng Jiang Liu
    BMC Gastroenterology.2024;[Epub]     CrossRef
  • Soy Product Consumption and the Risk of Cancer: A Systematic Review and Meta-Analysis of Observational Studies
    Chenting Wang, Keqing Ding, Xuanzhen Xie, Jinyue Zhou, Pengju Liu, Shuang Wang, Ting Fang, Guozhang Xu, Chunlan Tang, Hang Hong
    Nutrients.2024; 16(7): 986.     CrossRef
  • Interaction between dietary potassium intake and TNF-α rs1800629 genetic polymorphism in gastric cancer risk: a case–control study conducted in Korea
    Tao Thi Tran, Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jeongseon Kim
    British Journal of Nutrition.2023; 130(5): 887.     CrossRef
  • Association between soy products, fruits, vegetables, and dairy products and gastric cancer risk in Helicobacter pylori-infected subjects: a case-control study in Korea
    Jung Hyun Kwak, Chang Soo Eun, Dong Soo Han, Yong Sung Kim, Kyu Sang Song, Bo Youl Choi, Hyun Ja Kim
    Nutrition Research and Practice.2023; 17(1): 122.     CrossRef
  • Dietary intake and cancer incidence in Korean adults: a systematic review and meta-analysis of observational studies
    Ji Hyun Kim, Shinyoung Jun, Jeongseon Kim
    Epidemiology and Health.2023; 45: e2023102.     CrossRef
  • The association of dietary fibre intake and the IL13 rs20541 polymorphism with the risk of gastric cancer: a case-control study in Korea
    Tao Thi Tran, Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jeongseon Kim
    European Journal of Clinical Nutrition.2022; 76(7): 1031.     CrossRef
  • Dietary Polyphenol Intake and Gastric Cancer: A Systematic Review and Meta-Analysis
    Marcela de Araújo Fagundes, Alex Richard Costa Silva, Gisele Aparecida Fernandes, Maria Paula Curado
    Cancers.2022; 14(23): 5878.     CrossRef
  • Sex-dependent associations between MAP3K1 gene polymorphisms and soy products with the gastric cancer risk in Korea: a case-control study
    Jung Hyun Kwak, Chang Soo Eun, Dong Soo Han, Yong Sung Kim, Kyu Sang Song, Bo Youl Choi, Hyun Ja Kim
    BMC Gastroenterology.2022;[Epub]     CrossRef
  • Dietary patterns and gastric cancer risk in a Korean population: a case–control study
    Ji Hyun Kim, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jeongseon Kim
    European Journal of Nutrition.2021; 60(1): 389.     CrossRef
  • Possible Roles of Interleukin-4 and -13 and Their Receptors in Gastric and Colon Cancer
    Xujun Song, Benno Traub, Jingwei Shi, Marko Kornmann
    International Journal of Molecular Sciences.2021; 22(2): 727.     CrossRef
  • The association between soy‐based food and soy isoflavone intake and the risk of gastric cancer: a systematic review and meta‐analysis
    Yameng Wang, Jiaping Guo, Fei Yu, Yongmei Tian, Yongjun Wu, Lingling Cui, Li‐e Liu
    Journal of the Science of Food and Agriculture.2021; 101(13): 5314.     CrossRef
  • The Associations of Dietary Iron Intake and the Transferrin Receptor (TFRC) rs9846149 Polymorphism with the Risk of Gastric Cancer: A Case–Control Study Conducted in Korea
    Tao Thi Tran, Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jeongseon Kim
    Nutrients.2021; 13(8): 2600.     CrossRef
  • Identification of Dietary Pattern Networks Associated with Gastric Cancer Using Gaussian Graphical Models: A Case-Control Study
    Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jeongseon Kim
    Cancers.2020; 12(4): 1044.     CrossRef
  • Genome‐wide profiling of normal gastric mucosa identifies Helicobacter pylori‐ and cancer‐associated DNA methylome changes
    Hae Dong Woo, Nora Fernandez‐Jimenez, Akram Ghantous, Davide Degli Esposti, Cyrille Cuenin, Vincent Cahais, Il Ju Choi, Young‐Il Kim, Jeongseon Kim, Zdenko Herceg
    International Journal of Cancer.2018; 143(3): 597.     CrossRef
  • The association between dietary isoflavones intake and gastric cancer risk: a meta-analysis of epidemiological studies
    Jie You, Yafei Sun, Yacong Bo, Yiwei Zhu, Dandan Duan, Han Cui, Quanjun Lu
    BMC Public Health.2018;[Epub]     CrossRef
  • 9,978 View
  • 281 Download
  • 17 Web of Science
  • 17 Crossref
Close layer
Cancer Res Treat : Cancer Research and Treatment
© Korean Cancer Association.
Close layer
TOP