Cancer Research and Treatment

Original Article

A Study of Relationship of Atheroembolic Risk Factors with Postoperative Recovery in Renal Function after Partial Nephrectomy in Patients Staged T1-2 Renal Cell Carcinoma during Median 4-Year Follow-up: Sung Han Kim, Kyung Min Kang, Ami Yu, Jung Hoon Lee, Byung Ho Nam, Eun Sik Lee; Cancer Res Treat. 2016;48(1):288-296. Published online April 15, 2015; DOI: https://doi.org/10.4143/crt.2014.297

Purpose
The objective of this study is to evaluate the relationship of atheroembolic risk factors with postoperative recovery of renal function after on-clamp partial nephrectomy (PN) with warm ischemia in patients with staged T1-2 renal cell carcinoma (RCC).
Materials and Methods
A total of 234 patients from 2004 to 2012 were included, and their clinicopathologic and operative parameters, including atheroembolic risk factors were reviewed retrospectively. Renal function, as determined by estimated glomerular filtration rate (eGFR) and measurement of serum creatinine level (Cr) at each scheduled follow-up for a median four years, was compared between the high-risk (HR) group (n=49, ≥ five risk factors) and the low-risk (LR) group (n=185, < five risk factors).
Results
Except for baseline renal function and number of risk factors for atheroembolism, differences in characteristics between groups were comparatively insignificant. At 3 months after the operation, Cr and eGFR differed significantly between the two groups (p < 0.05), but no differences were observed afterward. Significant deterioration from baseline in Cr and eGFR was observed in both groups at 1 month after the operation, with a greater change in the HR group (p < 0.05). From measurement to measurement, significantly faster deterioration in Cr and eGFR was observed in the HR group than in the LR group until 6 months after the operation (Cr: LR, 0.02 mg/dL and HR, 0.13 mg/dL; eGFR: LR, 1.50 mL/min/1.73 m² and HR, 6.38 mL/min/1.73 m²; p < 0.05).
Conclusion
The presence of atheroembolic risk factors may negatively influence postoperative recovery of renal function after PN in patients with localized RCC.

Citations

Citations to this article as recorded by

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Clinical Genitourinary Cancer.2022; 20(1): e45. CrossRef
The Effect of Patient and Surgical Characteristics on Renal Function After Partial Nephrectomy
Andrew G. Winer, Emily C. Zabor, Michael J. Vacchio, A. Ari Hakimi, Paul Russo, Jonathan A. Coleman, Edgar A. Jaimes
Clinical Genitourinary Cancer.2018; 16(3): 191. CrossRef
The effect of predisposing atheroembolic risk factors on renal functional recovery between laparoscopy and open technique in patients with T1-stage renal cell carcinoma who underwent partial nephrectomy: a retrospective comparison study
Sung Han Kim, Jae Young Joung, Ho Kyung Seo, Kang Hyun Lee, Jinsoo Chung
Japanese Journal of Clinical Oncology.2017; 47(9): 876. CrossRef

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