Cancer Research and Treatment

Original Articles

Comparison of the 7th and the 8th AJCC Staging System for Non-metastatic D2-Resected Lymph Node–Positive Gastric Cancer Treated with Different Adjuvant Protocols: Jeong Il Yu, Do Hoon Lim, Jeeyun Lee, Won Ki Kang, Se Hoon Park, Joon Oh Park, Young Suk Park, Ho Yeong Lim, Seung Tae Kim, Su Jin Lee, Sung Kim, Tae Sung Sohn, Jun Ho Lee, Ji Yeong An, Min Gew Choi, Jae Moon Bae, Heejin Yoo, Kyunga Kim; Cancer Res Treat. 2019;51(3):876-885. Published online October 1, 2018; DOI: https://doi.org/10.4143/crt.2018.401

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Purpose
The purpose of this study was to compare prognostic differentiation performances of the 7th and the 8th edition of American Joint Commission on Cancer (AJCC) staging system for gastric cancer (GC) patients.
Materials and Methods
A total of 1,633 GC patients who underwent curative D2 resection followed by adjuvant chemotherapy alone (CA) or concurrent chemo-radiotherapy (CCRT) from 2004 to 2013 were included. Concordance index (c-index) was applied to compare the discriminatory ability.
Results
In the 8th edition, migration of stage was detected in 248 patients (15.2%). Among them, 121 patients were up-staged while 127 patients were down-staged. Overall, there was no statistically significant difference in the discriminatory ability between the 7th and 8th editions. The new edition of staging system, however, showed a trend of better prognostic performance not only in recurrence-free survival (c-index=0.734; 95% confidence interval [CI], 0.706 to 0.762 in the 7th edition vs. c-index=0.740; 95% CI, 0.712 to 0.768 in the 8th edition; p=0.14), but also in overall survival (c-index=0.717; 95% CI, 0.688 to 0.745 in the 7th edition vs. c-index=0.722; 95% CI, 0.694 to 0.751 in the 8th edition; p=0.19), especially in stage III. This finding was repeated in the subgroup analysis regardless of adjuvant CA or CCRT.
Conclusion
Generally, the 8th edition of AJCC staging system had failed to show a superior discriminatory ability for curatively D2 resected GC patients than the 7th edition, although there was a trend of better prognostic performance of the new edition, regardless of adjuvant treatment method.

Citations

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Construction of a modified TNM staging system and prediction model based on examined lymph node counts for gastric cancer patients at pathological stage N3
Hongyu Zhang, Nan Sun, Feng Li, Qiyang Wang, Zhao Sun, Yawei Zhang, Lei Wang, Chunlin Zhao, Yang Fu
Frontiers in Oncology.2025;[Epub] CrossRef
Normalization weighted combination scores re-evaluate TNM staging of gastric cancer: a retrospective cohort study based on a multicenter database
Junpeng Wu, Hao Wang, Xin Yin, Yufei Wang, Zhanfei Lu, Jiaqi Zhang, Yao Zhang, Yingwei Xue
International Journal of Surgery.2024; 110(1): 11. CrossRef
An analysis of the relationship of triglyceride glucose index with gastric cancer prognosis: A retrospective study
Chao Cai, Cheng Chen, Xiuli Lin, Huihui Zhang, Mingming Shi, Xiaolei Chen, Weisheng Chen, Didi Chen
Cancer Medicine.2024;[Epub] CrossRef
Revolutionizing T3-4N0-2M0 gastric cancer staging with an innovative pathologic N classification system
Kailai Yin, Xuanhong Jin, Yang Pan, Mengli Zi, Yingsong Zheng, Yubo Ma, Chuhong Pang, Kang liu, Jinxia Chen, Yizhou Wei, Dujiang Liu, Xiangdong Cheng, Li Yuan
Journal of Gastrointestinal Surgery.2024; 28(8): 1283. CrossRef
A Comprehensive Review of Prognostic Factors in Patients with Gastric Adenocarcinoma
Styliani Mantziari, Penelope St Amour, Francesco Abboretti, Hugo Teixeira-Farinha, Sergio Gaspar Figueiredo, Caroline Gronnier, Dimitrios Schizas, Nicolas Demartines, Markus Schäfer
Cancers.2023; 15(5): 1628. CrossRef
A Substage Increase in The AJCC Classification System Improves Prognostic Prediction in Stage III Gastric Cancer With Insufficient Lymph Nodes Removed
Ri-Sheng Zhao, Yi-Nan Liu, Wei-Gang Dai, Si-Le Chen, Jin-Ning Ye, Er-Tao Zhai, Shi-Rong Cai, Jian-Hui Chen
Frontiers in Oncology.2021;[Epub] CrossRef
Current therapeutic options for gastric adenocarcinoma
C.R. Akshatha, Smitha Bhat, R. Sindhu, Dharini Shashank, Sarana Rose Sommano, Wanaporn Tapingkae, Ratchadawan Cheewangkoon, Shashanka K. Prasad
Saudi Journal of Biological Sciences.2021; 28(9): 5371. CrossRef
Outcomes of Radiotherapy for Mesenchymal and Non-Mesenchymal Subtypes of Gastric Cancer
Jeong Il Yu, Hee Chul Park, Jeeyun Lee, Changhoon Choi, Won Ki Kang, Se Hoon Park, Seung Tae Kim, Tae Sung Sohn, Jun Ho Lee, Ji Yeong An, Min Gew Choi, Jae Moon Bae, Kyoung-Mee Kim, Heewon Han, Kyunga Kim, Sung Kim, Do Hoon Lim
Cancers.2020; 12(4): 943. CrossRef

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Long-Term Low-Dose Aspirin Use Reduces Gastric Cancer Incidence: A Nationwide Cohort Study: Young-Il Kim, So Young Kim, Ji Hyun Kim, Jun Ho Lee, Young-Woo Kim, Keun Won Ryu, Jong-Hyock Park, Il Ju Choi; Cancer Res Treat. 2016;48(2):798-805. Published online July 14, 2015; DOI: https://doi.org/10.4143/crt.2015.117

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Purpose
The aim of this study was to investigate whether aspirin use can reduce the incidence of gastric cancer in patients with hypertension or type 2 diabetes. Materials and Methods A total of 200,000 patients with hypertension or type 2 diabetes were randomly selected from the Korean National Health Insurance claim database. Of these, 3,907 patients who used 100 mg of aspirin regularly (regular aspirin users) and 7,808 patients who did not use aspirin regularly (aspirin non-users) were selected at a frequency of 1:2, matched by age, sex, comorbid illnesses (type 2 diabetes and hypertension), and observation periods. The incidence of gastric cancer in this cohort was then assessed during the observation period of 2004 to 2010.
Results
In the matched cohort, the incidence rates of gastric cancer were 0.8% (31/3,907) for regular aspirin users and 1.1% (86/7,808) for aspirin non-users, but the cumulative incidence rates were not significantly different between groups (p=0.116, log-rank test). However, in multivariate analysis, regular aspirin users had a reduced risk of gastric cancer (adjusted hazard ratio [aHR], 0.71; 95% confidential interval [CI], 0.47 to 1.08; p=0.107). Duration of aspirin use showed significant association with reduction of gastric cancer risk (aHR for each year of aspirin use, 0.85; 95% CI, 0.73 to 0.99; p=0.044), particularly in patients who used aspirin for more than 3 years (aHR, 0.40; 95% CI, 0.16 to 0.98; p=0.045). Conclusion Long-term low-dose aspirin use was associated with reduced gastric cancer risk in patients with hypertension or type 2 diabetes.

Citations

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Dose-response relationship between aspirin and gastric cancer risk: A systematic review and meta-analysis
Shan Zhang, Hongwei Wang, Jingjing Ji, Ruiyu Chai, Shiyi Song, Jikang Shi, Siyu Liu
Cancer Epidemiology.2025; 97: 102873. CrossRef
Exposure to Commonly Used Drugs and the Risk of Gastric Cancer: An Umbrella Review of Meta-Analyses
Xiao Bai, Si-Qi Ding, Xue-Ping Zhang, Ming-Hao Han, Dong-Qiu Dai
Cancers.2023; 15(2): 372. CrossRef
In Vitro Assessment of the Synergistic Effect of Aspirin and 5-Fluorouracil in Colorectal Adenocarcinoma Cells
Monica Susan, Ioana Macasoi, Iulia Pinzaru, Cristina Dehelean, Iosif Ilia, Razvan Susan, Ioana Ionita
Current Oncology.2023; 30(7): 6197. CrossRef
Prediction algorithm for gastric cancer in a general population: A validation study
Martin C. S. Wong, Eman Yee‐man Leung, Sarah T. Y. Yau, Sze Chai Chan, Shaohua Xie, Wanghong Xu, Junjie Huang
Cancer Medicine.2023; 12(21): 20544. CrossRef
Evaluation of clopidogrel use on gastric precancerous lesions: Does it have chemopreventive effect?
Taner AKYOL
Journal of Medicine and Palliative Care.2023; 4(5): 524. CrossRef
Safety and effectiveness of low-dose aspirin for the prevention of gastrointestinal cancer in adults without atherosclerotic cardiovascular disease: a population-based cohort study
Jessica J P Shami, Jiaxi Zhao, Swathi Pathadka, Eric Yuk Fai Wan, Joseph Edgar Blais, Pareen Vora, Montse Soriano-Gabarró, Ka Shing Cheung, W K Leung, Ian C K Wong, Esther W Chan
BMJ Open.2022; 12(2): e050510. CrossRef
Association Between Aspirin Use and Gastric Adenocarcinoma: A Prospective Cohort Study
Sohee Kwon, Wenjie Ma, David A. Drew, Samuel J. Klempner, Brianna M. Leonardo, Jacqueline J. Flynn, Yin Cao, Edward L. Giovannucci, Ying Bao, Charles S. Fuchs, Mingyang Song, Andrew T. Chan
Cancer Prevention Research.2022; 15(4): 265. CrossRef
Association of Aspirin, Metformin, and Statin Use with Gastric Cancer Incidence and Mortality: A Nationwide Cohort Study
Mi Hee Cho, Tae Gon Yoo, Su-Min Jeong, Dong Wook Shin
Cancer Prevention Research.2021; 14(1): 95. CrossRef
Antibreast Cancer Activity of Aspirin-Conjugated Chalcone Polymeric Micelles
Do Young Lee, Kang Pa Lee, Suji Beak, Ji Su Park, Young Jin Kim, Kil-Nam Kim, Song-Rae Kim, Myeong Sik Yoon
Macromolecular Research.2021; 29(1): 105. CrossRef
Effect of frequently prescribed drugs on gastric cancer risk
Theresa Weltermann, Christian Schulz, Lukas Macke
Best Practice & Research Clinical Gastroenterology.2021; : 101741. CrossRef
Aspirin Use and Common Cancer Risk: A Meta-Analysis of Cohort Studies and Randomized Controlled Trials
Lijuan Wang, Rongqi Zhang, Lili Yu, Jiarui Xiao, Xuan Zhou, Xinxuan Li, Peige Song, Xue Li
Frontiers in Oncology.2021;[Epub] CrossRef
The Relationship between Diabetes Mellitus and Gastric Cancer and the Potential Benefits of Metformin: An Extensive Review of the Literature
Chin-Hsiao Tseng
Biomolecules.2021; 11(7): 1022. CrossRef
Effect of aspirin use on gastric cancer incidence and survival: A systematic review and meta‐analysis
Ryota Niikura, Yoshihiro Hirata, Yoku Hayakawa, Takuya Kawahara, Atsuo Yamada, Kazuhiko Koike
JGH Open.2020; 4(2): 117. CrossRef
Positive association between dietary inflammatory index and gastric cancer risk: A systematic review and meta-analysis
Ying Liang, Haoyan Jiao, Lingbo Qu, Hao Liu
Nutrition and Cancer.2020; 72(8): 1290. CrossRef
Efficacy of Aspirin in the Primary Prevention of Cardiovascular Diseases and Cancer in the Elderly: A Population-Based Cohort Study in Korea
Minji Jung, Sukhyang Lee
Drugs & Aging.2020; 37(1): 43. CrossRef
Safety of Proton Pump Inhibitors Questioned Based on a Large Randomized Trial of Patients Receiving Rivaroxaban or Aspirin
Johanna Simin, Qing Liu, Romina Fornes, Nele Brusselaers
Gastroenterology.2020; 158(4): 1172. CrossRef
De novo malignancy risk in patients undergoing the first percutaneous coronary intervention: A nationwide population-based cohort study
Soongu Kwak, You-Jung Choi, Soonil Kwon, Seo-Young Lee, Seokhun Yang, Inki Moon, Hyun-Jung Lee, Heesun Lee, Jun-Bean Park, Kyungdo Han, Yong-Jin Kim, Hyung-Kwan Kim
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Use of proton pump inhibitors and histamine-2 receptor antagonists and risk of gastric cancer in two population-based studies
Peipei Liu, Úna C. McMenamin, Brian T. Johnston, Peter Murchie, Lisa Iversen, Amanda J. Lee, Pauline A. J. Vissers, Chris R. Cardwell
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Low‐dose aspirin and risk of gastric and oesophageal cancer: A population‐based study in the United Kingdom using The Health Improvement Network
Luis A. García Rodríguez, Montse Soriano‐Gabarró, Pareen Vora, Lucía Cea Soriano
International Journal of Cancer.2020; 147(9): 2394. CrossRef
Preventing Metachronous Gastric Cancer after the Endoscopic Resection of Gastric Epithelial Neoplasia: Roles of Helicobacter pylori Eradication and Aspirin
Jiro Watari, Toshihiko Tomita, Katsuyuki Tozawa, Tadayuki Oshima, Hirokazu Fukui, Hiroto Miwa
Gut and Liver.2020; 14(3): 281. CrossRef
Acetylsalicylic Acid Exerts Potent Antitumor and Antiangiogenic Effects in Cutaneous and Uveal Melanoma Cell Lines
Dominique Fausto de Souza, Thupten Tsering, Miguel N. Burnier , Vasco Bravo-Filho, Ana Beatriz Toledo Dias, Mohamed Abdouh, Alicia Goyeneche, Julia Valdemarin Burnier
Ocular Oncology and Pathology.2020; 6(6): 442. CrossRef
Associations between aspirin use and the risk of cancers: a meta-analysis of observational studies
Yan Qiao, Tingting Yang, Yong Gan, Wenzhen Li, Chao Wang, Yanhong Gong, Zuxun Lu
BMC Cancer.2018;[Epub] CrossRef
Cumulative Dose Threshold for the Chemopreventive Effect of Aspirin Against Gastric Cancer
Min-hyung Kim, Jooyoung Chang, Warrick Junsuk Kim, Samprit Banerjee, Sang Min Park
American Journal of Gastroenterology.2018; 113(6): 845. CrossRef
Aspirin associated with risk reduction of secondary primary cancer for patients with head and neck cancer: A population-based analysis
Yu-Shan Lin, Chih-Ching Yeh, Shiang-Fu Huang, Yi-Sheng Chou, Li-Tang Kuo, Fung-Chang Sung, Chih-Hsin Muo, Chien-Tien Su, Fu-Hsiung Su, Mohammad R. Akbari
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Cumulative Dose Threshold for the Chemopreventive Effect of Aspirin Against Gastric Cancer
Min-hyung Kim, Jooyoung Chang, Warrick Junsuk Kim, Samprit Banerjee, Sang Min Park
American Journal of Gastroenterology.2018; 113(6): 845. CrossRef
Chemoprevention of Gastric Cancer: Non-steroidal Anti-inflammatory Drugs Including Aspirin
Kee Don Choi
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2017; 17(4): 169. CrossRef
Effects of long-term aspirin use on molecular alterations in precancerous gastric mucosa in patients with and without gastric cancer
Yuki Michigami, Jiro Watari, Chiyomi Ito, Ken Hara, Takahisa Yamasaki, Takashi Kondo, Tomoaki Kono, Katsuyuki Tozawa, Toshihiko Tomita, Tadayuki Oshima, Hirokazu Fukui, Takeshi Morimoto, Kiron M. Das, Hiroto Miwa
Scientific Reports.2017;[Epub] CrossRef
Aspirin enhances the cytotoxic activity of bortezomib against myeloma cells via suppression of Bcl-2, survivin and phosphorylation of AKT
Jiang-Hua Ding, Li-Ya Yuan, Guo-An Chen
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Aspirin and non-steroidal anti-inflammatory drugs use reduce gastric cancer risk: A dose-response meta-analysis
Xuan-zhang Huang, You Chen, Jian Wu, Xi Zhang, Cong-cong Wu, Chao-ying Zhang, Shuang-shuang Sun, Wen-jun Chen
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Prognostic value of a novel FPR biomarker in patients with surgical stage II and III gastric cancer
Jing Zhang, Shu-Qi Li, Zhi-Hua Liao, Yu-Huan Jiang, Qing-Gen Chen, Bo Huang, Jing Liu, Yan-Mei Xu, Jin Lin, Hou-Qun Ying, Xiao-Zhong Wang
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Dietary inflammatory index and the risk of gastric cancer in a Korean population
Sunghee Lee, Jeonghee Lee, Il Ju Choi, Young-Woo Kim, Keun Won Ryu, Young-Il Kim, Jin-Kyoung Oh, Binh Thang Tran, Jeongseon Kim
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Characteristics of Synchronous Cancers in Gastric Cancer Patients: Ja Seong Bae, Jun Ho Lee, Keun Won Ryu, Young Woo Kim, Jae Moon Bae; Cancer Res Treat. 2006;38(1):25-29. Published online February 28, 2006; DOI: https://doi.org/10.4143/crt.2006.38.1.25

Abstract PDF PubReader ePub

Purpose

The primary objective of the current study was to investigate the characteristics of synchronous cancers in gastric cancer patients.

Materials and Methods

We analyzed the 2,237 patients who were diagnosed between December 2000 and December 2003 with gastric cancer and synchronous cancers of organs other than the stomach.

Results

73 (3.3%) of a total of 2,237 gastric cancer patients had synchronous primary cancers. Among these 73 patients, 71 had one synchronous cancer, and two patients had double synchronous cancers. Colorectal cancer (26 patients, 34.7%) was the most frequently encountered synchronous cancer, followed by cancer of the lung (16 patients, 21.3%), esophagus (13 patients, 17.2%), and liver (8 patients, 10.7%). Synchronous cancers were detected with increased frequency in the elderly, in the patients with multiple gastric cancers, in the patients with differentiated gastric cancer, and in the patients with early gastric cancer, as determined on univariate analysis, but the differentiation of gastric cancers was the only risk factor for synchronous cancers on the multivariate analysis.

Conclusions

The differentiation of gastric cancer cells may be a risk factor for synchronous cancers in gastric cancer patients. Careful surveillance by the physician for synchronous cancer is warranted for the patients suffering from gastric cancer.

Citations

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Rare metastasis of the urinary bladder from esophageal squamous cell carcinoma: a case report
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Gastric cancer and intrahepatic cholangiocarcinoma
Alex Emmanuel Elobu, Ashok Thorat, Vianney Kweyamba, Rakesh Rai
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Clinicopathologic characteristics and survival rate in patients with synchronous or metachronous double primary colorectal and gastric cancer
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Heather Katz, Hassaan Jafri, Linda Brown, Toni Pacioles
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Ji-Hoon Kim, Dae-Woon Eom, Cheon-Soo Park, Jae-Young Kwak, Eun-Hwa Park, Jin-Ho Kwak, Hyuk-Jae Jang, Kun-Moo Choi, Myung-Sik Han
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I. Cho, J.Y. An, I.G. Kwon, Y.Y. Choi, J.H. Cheong, W.J. Hyung, S.H. Noh
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Concurrent Robot-Assisted Distal Gastrectomy and Partial Nephrectomy for Synchronous Early Gastric Cancer and Renal Cell Carcinoma: An Initial Experience
Jieun Kim, Su Mi Kim, Jeong Eun Seo, Min Gew Choi, Jun Ho Lee, Tae Sung Sohn, Sung Kim, Jae Moon Bae, Seong Il Seo
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Concurrent Robot-Assisted Distal Gastrectomy and Partial Nephrectomy for Synchronous Early Gastric Cancer and Renal Cell Carcinoma: An Initial Experience
Jieun Kim, Su Mi Kim, Jeong Eun Seo, Min Gew Choi, Jun Ho Lee, Tae Sung Sohn, Sung Kim, Jae Moon Bae, Seong Il Seo
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Boon Eu Andrew KWEK, Tiing Leong ANG, Kwong Ming FOCK, Eng Kiong TEO
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Case Report

A Case of Pancreatic Serous Cystadenoma Associated with Papillary Thyroid Cancer: Jin Hong Park, Chang Ryoul Lee, Jun Ho Lee, So Jin Choi, Seong Ho Choi, Seong Pyo Son; J Korean Cancer Assoc. 1999;31(1):201-207.

Abstract PDF: The most common pancreatic cystic lesion is pancreatic pseudocyst which represents about 85%. Primary cystic neoplasms represent about 10 to 15% of the lesion. Pathologically cystic neoplasms can be classified into serous cystadenoma, mucinous cystadenoma and papillary cystic neoplasm by epithelial lining-cell, whereas pseudocyst is characterized by fibrotic capsules. Mucinous form is known to be premalignant or malignant and serous cystadenoma was known to be benign in the past, but recently 4 cases of malignant transformation have been reported. Serous cystadenoma is described under a variety of names, including microcystic adenoma and glycogen-rich cystadenoma but recently macroqystic variants have been reported. Serous cystadenoma is most commonly seen in middle aged women with symptoms of vague upper abdominal pain or palpable mass. It is sometimes associated with extra- pancreatic diseases such as gallstones, diabetes mellitus, hypertension, duodenal ulcers, sterility, obesity and thymic dysfunction, but coexisting papillary thyroid cancer have been reported in only 2 cases to our knowledge. The pathogenesis of associated diseases is unknown and appears to be due to function of age of the patients or incidental occurrence. Herein, we report a patient who had a pancreatic serous cystadenoma coexisting with papillary thyroid cancer. Since pancreatic serous cystadenoma can occur in association with papaillary thyroid cancer, examination of thyroid seems to be advisable when pancreatic serous cystadenoma is found.

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