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Original Articles
- Genitourinary cancer
- TNM-Based Head-to-Head Comparison of Urachal Carcinoma and Urothelial Bladder Cancer: Stage-Matched Analysis of a Large Multicenter National Cohort
- Sang Hun Song, Jaewon Lee, Young Hwii Ko, Jong Wook Kim, Seung Il Jung, Seok Ho Kang, Jinsung Park, Ho Kyung Seo, Hyung Joon Kim, Byong Chang Jeong, Tae-Hwan Kim, Se Young Choi, Jong Kil Nam, Ja Yoon Ku, Kwan Joong Joo, Won Sik Jang, Young Eun Yoon, Seok Joong Yun, Sung-Hoo Hong, Jong Jin Oh
- Cancer Res Treat. 2023;55(4):1337-1345. Published online April 17, 2023
- DOI: https://doi.org/10.4143/crt.2023.417
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Abstract
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Supplementary Material
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ePub - Purpose
Outcome analysis of urachal cancer (UraC) is limited due to the scarcity of cases and different staging methods compared to urothelial bladder cancer (UroBC). We attempted to assess survival outcomes of UraC and compare to UroBC after stage-matched analyses.
Materials and Methods
Total 203 UraC patients from a multicenter database and 373 UroBC patients in single institution from 2000 to 2018 were enrolled (median follow-up, 32 months). Sheldon stage conversion to corresponding TNM staging for UraC was conducted for head-to-head comparison to UroBC. Perioperative clinical variables and pathological results were recorded. Stage-matched analyses for survival by stage were conducted.
Results
UraC patients were younger (mean age, 54 vs. 67 years; p < 0.001), with 163 patients (80.3%) receiving partial cystectomy and 23 patients (11.3%) radical cystectomy. UraC was more likely to harbor ≥ pT3a tumors (78.8% vs. 41.8%). While 5-year recurrence-free survival, cancer-specific survival (CSS) and overall survival were comparable between two groups (63.4%, 67%, and 62.1% in UraC and 61.5%, 75.9%, and 67.8% in UroBC, respectively), generally favorable prognosis for UraC in lower stages (pT1-2) but unfavorable outcomes in higher stages (pT4) compared to UroBC was observed, although only 5-year CSS in ≥ pT4 showed statistical significance (p=0.028). Body mass index (hazard ratio [HR], 0.929), diabetes mellitus (HR, 1.921), pathologic T category (HR, 3.846), and lymphovascular invasion (HR, 1.993) were predictors of CSS for all patients.
Conclusion
Despite differing histology, UraC has comparable prognosis to UroBC with relatively favorable outcome in low stages but worse prognosis in higher stages. The presented system may be useful for future grading and risk stratification of UraC. -
Citations
Citations to this article as recorded by
- Urachal Signet Ring Cell Carcinoma: A Clinicopathological Analysis of 28 Cases
Natalie South, Ioana Maria Mihai, Vickie Wang, Mehdi Agoumi, Charles Guo, Gang Wang
Current Oncology.2026; 33(3): 153. CrossRef - Surgical Reporting and Prognostic Stratification in Urachal Adenocarcinoma: Considerations Arising From a Recent Single-center Cohort Study
Stefanie Herrmann, Maximilian Burger, Ingmar Wolff, Matthias May
Clinical Genitourinary Cancer.2026; 24(5): 102579. CrossRef - Urachal Carcinomas: A Comprehensive Systematic Review and Meta-analysis
Caio Vinícius Suartz, Lucas Motta Martinez, Marcelo Henrique Lima Silvestre, Richard Dobrucki de Lima, Pedro Henrique Souza Brito, Ketlyn Assunção Galhardo, Roberto Iglesias Lopes, Victor Hondo Silva de Moraes, Caio Mazzonetto Teofilo de Moraes, Luana Cov
International braz j urol.2025;[Epub] CrossRef - Clinical Presentation and Targeted Interventions in Urachal Adenocarcinoma: A Single-Institution Case Series and Review of Emerging Therapies
Akshay Mathavan, Akash Mathavan, Rodrigo Murillo-Alvarez, Kriti Gera, Urszula Krekora, Aaron J. Winer, Mohit Mathavan, Ellery Altshuler, Brian Hemendra Ramnaraign
Clinical Genitourinary Cancer.2024; 22(1): 67. CrossRef - Robotic‐assisted approaches to urachal carcinoma: A comprehensive systematic review of the safety and efficacy outcomes
Caio Vinícius Suartz, Lucas Motta Martinez, Pedro Henrique Brito, Carlos Victori Neto, Maurício Dener Cordeiro, Luiz Antonio Assan Botelho, Fábio Pescarmona Gallucci, José Maurício Mota, William Carlos Nahas, Leopoldo Alves Ribeiro‐Filho
BJUI Compass.2024; 5(3): 327. CrossRef
- Urachal Signet Ring Cell Carcinoma: A Clinicopathological Analysis of 28 Cases
- 7,157 View
- 217 Download
- 4 Web of Science
- 5 Crossref
- The Impact of Skin Problems on the Quality of Life in Patients Treated with Anticancer Agents: A Cross-Sectional Study
- Jaewon Lee, Jin Lim, Jong Seo Park, Miso Kim, Tae-Yong Kim, Tae Min Kim, Kyung-Hun Lee, Bhumsuk Keam, Sae-Won Han, Je-Ho Mun, Kwang Hyun Cho, Seong Jin Jo
- Cancer Res Treat. 2018;50(4):1186-1193. Published online December 14, 2017
- DOI: https://doi.org/10.4143/crt.2017.435
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Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
Patients treated with anticancer agents often experience a variety of treatment-related skin problems, which can impair their quality of life.
Materials and Methods
In this cross-sectional study, Dermatology Life Quality Index (DLQI) and clinical information were evaluated in patients under active anticancer treatment using a questionnaire survey and their medical records review.
Results
Of 375 evaluated subjects with anticancer therapy, 136 (36.27%) and 114 (30.40%) were treated for breast cancer and colorectal cancer, respectively. We found that women, breast cancer, targeted agent use, and longer duration of anticancer therapy were associated with higher dermatology-specific quality of life distraction. In addition, itching, dry skin, easy bruising, pigmentation, papulopustules on face, periungual inflammation, nail changes, and palmoplantar lesions were associated with significantly higher DLQI scores. Periungual inflammation and palmoplantar lesions scored the highest DLQI.
Conclusion
We believe our findings can be helpful to clinicians in counseling and managing the patients undergoing anticancer therapy. -
Citations
Citations to this article as recorded by- Long-Term Health Issues of Adolescent and Young Adult Breast Cancer Survivors
Noëlle J.M.C. Vrancken Peeters, Marianne J. Heins, Gioele Re, Marleen Kok, Iris M.C. van der Ploeg, Winette T.A. van der Graaf, Olga Husson
Clinical Breast Cancer.2026; 26(3): 200. CrossRef - Perspectives on managing skin manifestations in cancer patients: a multidisciplinary mixed-method survey of oncologists and dermatologists
Davide Fattore, Omalkhair Abulkhair, Ola M. Reda Khorshid, Tanios Bou Khalil, Rania H. Kafrouny, Michele Cherfane
Supportive Care in Cancer.2026;[Epub] CrossRef - Managing Skin Side Effects Associated With Oncology Treatments: Asian Perspective on Use of Dermocosmetics
Meng Pan, Jianguo Sun, Makoto Kawashima, You Chan Kim, Mison Chun, Chia‐Yu Chu, Yi‐Hsin Liang, Mee Chang, Delphine Kerob, Brigitte Dreno
Asia-Pacific Journal of Clinical Oncology.2026; 22(2): 186. CrossRef - Cutaneous adverse events with CDK4/6 inhibitors in breast cancer: a systematic review and meta-analysis
Rui Liu, Jiayong Cui, Ze Liu, Zhen Liu, Hengheng Zhang, Jiuda Zhao, Guoshuang Shen
Archives of Dermatological Research.2026;[Epub] CrossRef - Skin health in oncology: evidence-based skin care for cancer patients
Alexander Kaminsky, Sara Suhl, Yoni Sacknovitz, Gary K Schwartz, Sandhya Deverapalli, Larisa J Geskin
The Oncologist.2026;[Epub] CrossRef - A comprehensive study of adverse effects of chemotherapy on female breast cancer patients in NORI Cancer Hospital, Islamabad in a developing country
Abdullah, Areesha Abid, Humza Saeed, Zabeehullah, Uswa Iftikhar, Muhammad Khubaib Arshad, Muhammad Uzair Shahid, Tayyab Rasool, Faizan Fazal, Aman Goyal, Anum Akbar
Journal of Oncology Pharmacy Practice.2025; 31(6): 939. CrossRef - The Importance of Cosmetics in Oncological Patients. Survey of Tolerance of Routine Cosmetic Care in Oncological Patients
María-Elena Fernández-Martín, Jose V. Tarazona, Natalia Hernández-Cano, Ander Mayor Ibarguren
Cosmetics.2025; 12(4): 137. CrossRef - Spectrum of sensitive skin in India: a collaborative expert position statement
Deepika Pandhi, Arun C. Inamadar, Abir Saraswat, Abhishek De, Anchala Parthasaradhi, B. S. Chandrasekhar, Malavika Kohli, Manjunath Shenoy, Murlidhar Rajagopalan, Pravin Banodkar, Saumya Panda, Shital Poojary, Priti Thakor, Ruchi Shah, Someshwar Rayasam
Frontiers in Medicine.2025;[Epub] CrossRef - The Impact of Dermatologic Adverse Events on the Quality of Life of Oncology Patients: A Review of the Literature
Annika Belzer, Jolanta J. Pach, Kailyn Valido, Jonathan S. Leventhal
American Journal of Clinical Dermatology.2024; 25(3): 435. CrossRef - Quality of Life Impact in Patients with Cutaneous Toxicities Caused by Epidermal Growth Factor Receptor Inhibitors and Immunotherapy
Maria Mannino, Pietro Sollena, Alessandro Di Stefani, Ernesto Rossi, Ettore D’Argento, Giovanni Schinzari, Giampaolo Tortora, Ketty Peris
Dermatology.2024; 240(4): 523. CrossRef - Chemotherapy induced alopecia in breast cancer patients: A monocentric prospective study
Wala Ben Kridis, Olfa Boudawara, Afef Khanfir
Breast Disease.2024; 43(1): 251. CrossRef - Impact of Xerosis in Patients With Cancer Receiving Epidermal Growth Factor Receptor or Mitogen-Activated Protein Kinase Inhibitors: ATIXI, A Non-Interventional, Prospective, Pilot Study
Pietro Quaglino, Giuseppe Argenziano, Emi Dika, Michela Starace, Simone Amabile, Paolo Fava, Elvira Moscarella, Bianca Maria Piraccini, Alain Delarue, Olivia Dialla, Fabienne Zumaglini, Giampiero Girolomoni
Dermatology Practical & Conceptual.2024; 14(4): e2024259. CrossRef - Global trends in adolescent and young adult female cancer burden, 1990-2021: insights from the Global Burden of Disease study
Z. Huang, J. Wang, H. Liu, B. Wang, M. Qi, Z. Lyu, H. Liu
ESMO Open.2024; 9(11): 103958. CrossRef - Dermatologic toxicities of chemotherapy: an educational intervention for skin of color women with breast cancer
Maham Ahmad, Sabrina Saeed, Brianna Olamiju, Andrea Silber, Jonathan Leventhal
International Journal of Women’s Dermatology.2023; 9(1): e073. CrossRef - Aloe vera gel for prevention of chemotherapy-induced hyperpigmentation: Four case reports
Chia-Chi Chiu, Yi-Wen Hsiao, Yu-Chuan Wen, Tsung-Yen Chang, Shih-Hsiang Chen, Tang-Her Jaing
Medicine.2023; 102(25): e34037. CrossRef - Skin-related Quality of Life in Patients with Lung Cancer Taking Oral Targeted Agents: A Single-Center, Cross-Sectional Study
Joo Mi Park, Jeong Hye Kim
Asian Oncology Nursing.2023; 23(2): 84. CrossRef - Dermatological Side Effects of Cancer Treatment: Psychosocial Implications—A Systematic Review of the Literature
Vera Almeida, Daniela Pires, Marta Silva, Maribel Teixeira, Ricardo João Teixeira, André Louro, Maria Alzira Pimenta Dinis, Maria Ferreira, Ana Teixeira
Healthcare.2023; 11(19): 2621. CrossRef - The role of dermocosmetics in the management of cancer-related skin toxicities: international expert consensus
Brigitte Dreno, Kiarash Khosrotehrani, Giselle De Barros Silva, Julie Ryan Wolf, Delphine Kerob, Mark Trombetta, Etienne Atenguena, Pascale Dielenseger, Meng Pan, Florian Scotte, Ivan Krakowski, Mario Lacouture
Supportive Care in Cancer.2023;[Epub] CrossRef - Effectiveness and Tolerability of Natural Herbal Formulations in the Prevention of Radiation-Induced Skin Toxicity in Patients Undergoing Radiotherapy
Georgios Koukourakis, Georgios Pissakas, Christos G. Ganos, Gregory Sivolapenko, Dimitrios Kardamakis
The International Journal of Lower Extremity Wounds.2022; 21(1): 75. CrossRef - Effects of the epidermal growth factor receptor inhibitor, gefitinib, on lipid and hyaluronic acid synthesis in cultured HaCaT keratinocytes
Jang‐Hee Oh, Woojune Hur, Na Li, Seong Jin Jo
Experimental Dermatology.2022; 31(6): 918. CrossRef - An Emollient PLUS Balm Is Useful for the Management of Xerosis in Patients Treated for Cancer: A Real-World, Prospective, Observational, Multicenter Study
Véronique Vendrely, Ander Mayor-Ibarguren, Aline Stennevin, Ariadna Ortiz-Brugués
Dermatology and Therapy.2022; 12(3): 683. CrossRef - Nail pigmentation induced by chemotherapy: an observational study of patients with early-stage breast cancer
Kuikui Jiang, Simei Shi, Qiulian Lin, Peng Sun, Luan Zhang, Zhongyu Yuan, Ruoxi Hong, Yanxia Shi, Xia Liu, Jingmin Zhang, Jiajia Huang, Xiwen Bi, Wen Xia, Qianyi Lu, Qiufan Zheng, Shusen Wang, Fei Xu
Holistic Integrative Oncology.2022;[Epub] CrossRef - Cutaneous adverse events in patients receiving anticancer therapy in a tertiary hospital setting: the old and the new
Hae‐Jin Suh, Ángeles Flórez, Víctor Sacristán, Ángeles Rodríguez Martinez, Francisca Fernández, Lucía Vilanova‐Trillo, Manuel Constenla, Manuel Pereiro
International Journal of Dermatology.2021; 60(2): 208. CrossRef - The Impact of Acne, Atopic Dermatitis, Skin Toxicities and Scars on Quality of Life and the Importance of a Holistic Treatment Approach
Brigitte Dreno, Jean Michel Amici, Ann Laure Demessant-Flavigny, Charlotte Wright, Charles Taieb, Seemal R Desai, Andrew Alexis
Clinical, Cosmetic and Investigational Dermatology.2021; Volume 14: 623. CrossRef - Evaluating health related quality of life in outpatients receiving anti-cancer treatment: results from an observational, cross-sectional study
Hae-Jin Suh Oh, Ángeles Flórez Menéndez, Víctor Sacristán Santos, Ángeles Rodríguez Martínez, Francisca Fernández Ribeiro, Lucía Vilanova-Trillo, Manuel Constenla Figueiras, Manuel Pereiro Ferreiros
Health and Quality of Life Outcomes.2021;[Epub] CrossRef - Dermatologic conditions in women receiving systemic cancer therapy
Michelle N. Ferreira, Julie Y. Ramseier, Jonathan S. Leventhal
International Journal of Women's Dermatology.2019; 5(5): 285. CrossRef
- Long-Term Health Issues of Adolescent and Young Adult Breast Cancer Survivors
- 11,574 View
- 231 Download
- 30 Web of Science
- 26 Crossref
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