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Original Articles
- Comparison of the 7th and the 8th AJCC Staging System for Non-metastatic D2-Resected Lymph Node–Positive Gastric Cancer Treated with Different Adjuvant Protocols
- Jeong Il Yu, Do Hoon Lim, Jeeyun Lee, Won Ki Kang, Se Hoon Park, Joon Oh Park, Young Suk Park, Ho Yeong Lim, Seung Tae Kim, Su Jin Lee, Sung Kim, Tae Sung Sohn, Jun Ho Lee, Ji Yeong An, Min Gew Choi, Jae Moon Bae, Heejin Yoo, Kyunga Kim
- Cancer Res Treat. 2019;51(3):876-885. Published online October 1, 2018
- DOI: https://doi.org/10.4143/crt.2018.401
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Abstract
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Supplementary Material
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ePub - Purpose
The purpose of this study was to compare prognostic differentiation performances of the 7th and the 8th edition of American Joint Commission on Cancer (AJCC) staging system for gastric cancer (GC) patients.
Materials and Methods
A total of 1,633 GC patients who underwent curative D2 resection followed by adjuvant chemotherapy alone (CA) or concurrent chemo-radiotherapy (CCRT) from 2004 to 2013 were included. Concordance index (c-index) was applied to compare the discriminatory ability.
Results
In the 8th edition, migration of stage was detected in 248 patients (15.2%). Among them, 121 patients were up-staged while 127 patients were down-staged. Overall, there was no statistically significant difference in the discriminatory ability between the 7th and 8th editions. The new edition of staging system, however, showed a trend of better prognostic performance not only in recurrence-free survival (c-index=0.734; 95% confidence interval [CI], 0.706 to 0.762 in the 7th edition vs. c-index=0.740; 95% CI, 0.712 to 0.768 in the 8th edition; p=0.14), but also in overall survival (c-index=0.717; 95% CI, 0.688 to 0.745 in the 7th edition vs. c-index=0.722; 95% CI, 0.694 to 0.751 in the 8th edition; p=0.19), especially in stage III. This finding was repeated in the subgroup analysis regardless of adjuvant CA or CCRT.
Conclusion
Generally, the 8th edition of AJCC staging system had failed to show a superior discriminatory ability for curatively D2 resected GC patients than the 7th edition, although there was a trend of better prognostic performance of the new edition, regardless of adjuvant treatment method. -
Citations
Citations to this article as recorded by
- Construction of a modified TNM staging system and prediction model based on examined lymph node counts for gastric cancer patients at pathological stage N3
Hongyu Zhang, Nan Sun, Feng Li, Qiyang Wang, Zhao Sun, Yawei Zhang, Lei Wang, Chunlin Zhao, Yang Fu
Frontiers in Oncology.2025;[Epub] CrossRef - Normalization weighted combination scores re-evaluate TNM staging of gastric cancer: a retrospective cohort study based on a multicenter database
Junpeng Wu, Hao Wang, Xin Yin, Yufei Wang, Zhanfei Lu, Jiaqi Zhang, Yao Zhang, Yingwei Xue
International Journal of Surgery.2024; 110(1): 11. CrossRef - An analysis of the relationship of triglyceride glucose index with gastric cancer prognosis: A retrospective study
Chao Cai, Cheng Chen, Xiuli Lin, Huihui Zhang, Mingming Shi, Xiaolei Chen, Weisheng Chen, Didi Chen
Cancer Medicine.2024;[Epub] CrossRef - Revolutionizing T3-4N0-2M0 gastric cancer staging with an innovative pathologic N classification system
Kailai Yin, Xuanhong Jin, Yang Pan, Mengli Zi, Yingsong Zheng, Yubo Ma, Chuhong Pang, Kang liu, Jinxia Chen, Yizhou Wei, Dujiang Liu, Xiangdong Cheng, Li Yuan
Journal of Gastrointestinal Surgery.2024; 28(8): 1283. CrossRef - A Comprehensive Review of Prognostic Factors in Patients with Gastric Adenocarcinoma
Styliani Mantziari, Penelope St Amour, Francesco Abboretti, Hugo Teixeira-Farinha, Sergio Gaspar Figueiredo, Caroline Gronnier, Dimitrios Schizas, Nicolas Demartines, Markus Schäfer
Cancers.2023; 15(5): 1628. CrossRef - A Substage Increase in The AJCC Classification System Improves Prognostic Prediction in Stage III Gastric Cancer With Insufficient Lymph Nodes Removed
Ri-Sheng Zhao, Yi-Nan Liu, Wei-Gang Dai, Si-Le Chen, Jin-Ning Ye, Er-Tao Zhai, Shi-Rong Cai, Jian-Hui Chen
Frontiers in Oncology.2021;[Epub] CrossRef - Current therapeutic options for gastric adenocarcinoma
C.R. Akshatha, Smitha Bhat, R. Sindhu, Dharini Shashank, Sarana Rose Sommano, Wanaporn Tapingkae, Ratchadawan Cheewangkoon, Shashanka K. Prasad
Saudi Journal of Biological Sciences.2021; 28(9): 5371. CrossRef - Outcomes of Radiotherapy for Mesenchymal and Non-Mesenchymal Subtypes of Gastric Cancer
Jeong Il Yu, Hee Chul Park, Jeeyun Lee, Changhoon Choi, Won Ki Kang, Se Hoon Park, Seung Tae Kim, Tae Sung Sohn, Jun Ho Lee, Ji Yeong An, Min Gew Choi, Jae Moon Bae, Kyoung-Mee Kim, Heewon Han, Kyunga Kim, Sung Kim, Do Hoon Lim
Cancers.2020; 12(4): 943. CrossRef
- Construction of a modified TNM staging system and prediction model based on examined lymph node counts for gastric cancer patients at pathological stage N3
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- 241 Download
- 9 Web of Science
- 8 Crossref
- Characteristics of Synchronous Cancers in Gastric Cancer Patients
- Ja Seong Bae, Jun Ho Lee, Keun Won Ryu, Young Woo Kim, Jae Moon Bae
- Cancer Res Treat. 2006;38(1):25-29. Published online February 28, 2006
- DOI: https://doi.org/10.4143/crt.2006.38.1.25
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Abstract
PDFPubReaderePub
Purpose The primary objective of the current study was to investigate the characteristics of synchronous cancers in gastric cancer patients.
Materials and Methods We analyzed the 2,237 patients who were diagnosed between December 2000 and December 2003 with gastric cancer and synchronous cancers of organs other than the stomach.
Results 73 (3.3%) of a total of 2,237 gastric cancer patients had synchronous primary cancers. Among these 73 patients, 71 had one synchronous cancer, and two patients had double synchronous cancers. Colorectal cancer (26 patients, 34.7%) was the most frequently encountered synchronous cancer, followed by cancer of the lung (16 patients, 21.3%), esophagus (13 patients, 17.2%), and liver (8 patients, 10.7%). Synchronous cancers were detected with increased frequency in the elderly, in the patients with multiple gastric cancers, in the patients with differentiated gastric cancer, and in the patients with early gastric cancer, as determined on univariate analysis, but the differentiation of gastric cancers was the only risk factor for synchronous cancers on the multivariate analysis.
Conclusions The differentiation of gastric cancer cells may be a risk factor for synchronous cancers in gastric cancer patients. Careful surveillance by the physician for synchronous cancer is warranted for the patients suffering from gastric cancer.
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Citations
Citations to this article as recorded by- Rare metastasis of the urinary bladder from esophageal squamous cell carcinoma: a case report
Chunlei Zhang, Dehui Chang, Dongxing Wang, Jiale Zuo, Zhigang Cao
Frontiers in Oncology.2025;[Epub] CrossRef - Synchronous Triple Primary Gastrointestinal Tract Malignancies: A Case Report
Hyeon Min Rim, Young Min Rah, Ju Seok Kim
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2025; 25(4): 381. CrossRef - Synchronous Triple Malignancy of Esophagus, Pancreas, and Pyriform Sinus: A Prima Facie Report
Sekhar Saha, Varun Goel, Arnab Chakraborty, Vineet Talwar
Indian Journal of Surgical Oncology.2024; 15(S2): 349. CrossRef - Synchronous Gastric and Colonic Adenocarcinoma: A Case Report With its Molecular Implications
Lakshmipriya V, Sarah Grace Priyadarshini , Neha Agarwal, Padmapriya B S
Cureus.2024;[Epub] CrossRef - Triple metachronous primary cancer of uterus, colon, and breast cancer
Guanqiao Li, Jia Yao, Tangna Wu, Yaxiong Chen, Zhenping Wang, Yiming Wang, Fen Wang, Rui Zhong, Shiping Yang
Medicine.2020; 99(34): e21764. CrossRef - Gastric cancer and intrahepatic cholangiocarcinoma
Alex Emmanuel Elobu, Ashok Thorat, Vianney Kweyamba, Rakesh Rai
Formosan Journal of Surgery.2019; 52(3): 107. CrossRef - Clinicopathologic characteristics and survival rate in patients with synchronous or metachronous double primary colorectal and gastric cancer
Ji-Hyeon Park, Jeong-Heum Baek, Jun-Young Yang, Won-Suk Lee, Woon-Kee Lee
Korean Journal of Clinical Oncology.2018; 14(2): 83. CrossRef - Can positron emission tomography detect colorectal adenomas and cancers?
Kimihiro Igarashi, Kinichi Hotta, Kenichiro Imai, Yuichiro Yamaguchi, Sayo Ito, Noboru Kawata, Masaki Tanaka, Naomi Kakushima, Kohei Takizawa, Hiroyuki Matsubayashi, Masahiro Endo, Kouiku Asakura, Takuma Oishi, Tadakazu Shimoda, Hiroyuki Ono
Journal of Gastroenterology and Hepatology.2017; 32(3): 602. CrossRef - Triple synchronous primary malignancies: a rare occurrence
Heather Katz, Hassaan Jafri, Linda Brown, Toni Pacioles
BMJ Case Reports.2017; 2017: bcr-2017-219237. CrossRef - A Concurrence of Adenocarcinoma with Micropapillary Features and Composite Glandular-Endocrine Cell Carcinoma in the Stomach
Ji-Hoon Kim, Dae-Woon Eom, Cheon-Soo Park, Jae-Young Kwak, Eun-Hwa Park, Jin-Ho Kwak, Hyuk-Jae Jang, Kun-Moo Choi, Myung-Sik Han
Journal of Gastric Cancer.2016; 16(4): 266. CrossRef - Synchronous triple primary cancers occurring in the stomach, kidney, and thyroid
Sung Jin Oh, Dong Sik Bae, Byoung Jo Suh
Annals of Surgical Treatment and Research.2015; 88(6): 345. CrossRef - Risk factors for double primary malignancies and their clinical implications in patients with sporadic gastric cancer
I. Cho, J.Y. An, I.G. Kwon, Y.Y. Choi, J.H. Cheong, W.J. Hyung, S.H. Noh
European Journal of Surgical Oncology (EJSO).2014; 40(3): 338. CrossRef - Concurrent Robot-Assisted Distal Gastrectomy and Partial Nephrectomy for Synchronous Early Gastric Cancer and Renal Cell Carcinoma: An Initial Experience
Jieun Kim, Su Mi Kim, Jeong Eun Seo, Min Gew Choi, Jun Ho Lee, Tae Sung Sohn, Sung Kim, Jae Moon Bae, Seong Il Seo
Journal of Gastric Cancer.2014; 14(3): 211. CrossRef - Concurrent Robot-Assisted Distal Gastrectomy and Partial Nephrectomy for Synchronous Early Gastric Cancer and Renal Cell Carcinoma: An Initial Experience
Jieun Kim, Su Mi Kim, Jeong Eun Seo, Min Gew Choi, Jun Ho Lee, Tae Sung Sohn, Sung Kim, Jae Moon Bae, Seong Il Seo
Journal of Gastric Cancer.2014; 14(3): 211. CrossRef - Management of gastric epithelial neoplasia in patients requiring esophagectomy for esophageal cancer
H. I., G. H. Kim, D. Y. Park, Y. D. Kim, B. E. Lee, D. Y. Ryu, D. U. Kim, G. A. Song
Diseases of the Esophagus.2013; 26(6): 603. CrossRef - Synchronous lung and gastric cancers successfully treated with carboplatin and pemetrexed: a case report
Takashi Sato, Koji Tomaru, Tomoko Koide, Makoto Masuda, Masaki Yamamoto, Naoki Miyazawa, Yoshiaki Inayama, Takeshi Kaneko, Yoshiaki Ishigatsubo
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Kung-Ning Hu, Wei-Hong Lai, Po-Tsang Tseng, Wen-Ching Wang, Kun-Hung Shen
Urological Science.2012; 23(1): 28. CrossRef - Synchronous multifocal early gastric cancers and rectal adenocarcinoma: Lesson learnt from image‐enhanced endoscopy
Boon Eu Andrew KWEK, Tiing Leong ANG, Kwong Ming FOCK, Eng Kiong TEO
Journal of Digestive Diseases.2011; 12(3): 226. CrossRef - Clinical improvement of membranous nephropathy after endoscopic resection of double early gastrointestinal cancers
Satoshi Matsui, Hiroko Tsuji, Yukinobu Takimoto, Shinji Ono
Clinical and Experimental Nephrology.2011; 15(2): 285. CrossRef - Microsatellite Instability Is Associated with the Clinicopathologic Features of Gastric Cancer in Sporadic Gastric Cancer Patients
Shin Hyuk Kim, Byung Kyu Ahn, Young Su Nam, Joo Youn Pyo, Young Ha Oh, Kang Hong Lee
Journal of Gastric Cancer.2010; 10(4): 149. CrossRef - Second primary cancers in patients with gastric cancer
Oktay Buyukasik, Ahmet Hasdemir, Yusuf Gulnerman, Cavit Col, Ozgur Ikiz
Radiology and Oncology.2010;[Epub] CrossRef
- Rare metastasis of the urinary bladder from esophageal squamous cell carcinoma: a case report
- 11,524 View
- 58 Download
- 21 Crossref
- Effectiveness of Gastrectomy in Stage 4 Gastric Cancer with Hepatic Metastasis
- Jeong Hwan Yook, Sung Joon Kwon, Byung Ki Kim, Byung Jae Kim, Sung Kim, Seung Moon Noh, Young Jae Mok, Kyung Kyu Park, Byung Ju Park, Cho Hyun Park, Ho Yoon Bang, Jae Moon Bae, Young Jin Song, Du Hyun Yang, Dae Hyun Yang, Sung Tae Oh, Hyo Yung Yun, Moo Son Lee, Jong Inn Lee, Yong Kwan Cho, Dong Wook Choi, Sang Uk Han
- J Korean Cancer Assoc. 1999;31(3):441-447.
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Abstract
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- PURPOSE
The prognosis for patients with stage IV gastric cancer is very poor. However, recently, some studies have reported benefits from a gastric resection for metastatic gastric cancer. This clinical study was performed to evaluate the effectiveness of a noncurative gastrectomy in treating stage IV gastric cancer with hepatic metastasis.
MATERIALS AND METHODS
A retrospective analysis was performed on 98 gastric cancer patients who had undergone gastric resection, in spite of hepatic metastasis, between January 1990 and December 1996 at the Department of Surgery in 11 General Hospitals in Korea.
RESULTS
The average age was 58 years old, and the male-to-female ratio was 69: 29. The laboratory tests were unable to predict hepatic metastasis. In 54 cases, hepatic metastasis was not identified before the surgery. The most common location of gastric cancer was antrum (72 cases). The most common gross type was Bonmann type III (78 cases). The serosa-exposed cases were 80. The peritoneal seeding was combined in 17 cases. A total gastrectomy was performed in 18 cases and a distal gastrectomy in 80. Lymph-node dissection was performed in 23 Dl, and 51 D2 cases. Hepatic resection was performed in 36 cases, The frequent histologic types were moderately differentiated and poorly differentiated tubular adenocarcinoma. Postoperative adjuvant chemotherapy was done in 70 cases. The complication rate (7%) was low. The median survival time was 15 months, with mean survival time of 18 months. The 2-year and 3-year survival rates were 23%, and 7%, respectively. In the univariate analysis, good survival was closely related to limitation of hepatic metastasis to one lobe, a few metastases to both lobes, negativity of peritoneal seeding and lymph node dissection more than D2 (p<0.05), CONCLUSIONS: An aggressive gastric resection for stage IV gastric cancer with hepatic metastasis might be beneficial in lengthening the survival period. A prospective study is needed, especiaUy one with an exact evaluation and analysis of the quality of life between the gastrectomy and nonresection groups.
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