Cancer Research and Treatment

Original Articles

A Machine Learning Risk Prediction Model for Gastric Cancer with SHapley Additive exPlanations: Bomi Park, Chung Ho Kim, Jae Kwan Jun, Mina Suh, Kui Son Choi, Il Ju Choi, Hyun Jin Oh; Received August 29, 2024 Accepted December 15, 2024 Published online December 16, 2024; DOI: https://doi.org/10.4143/crt.2024.843 [Epub ahead of print]

Purpose
Gastric cancer (GC) prediction models hold potential for enhancing early detection by enabling the identification of high-risk individuals, facilitating personalized risk-based screening, and optimizing the allocation of healthcare resources.
Materials and Methods
In this study, we developed a machine learning-based GC prediction model utilizing data from the Korean National Health Insurance Service, encompassing 10,515,949 adults who had not been diagnosed with GC and underwent GC screening during 2013-2014, with a follow-up period of 5 years. The cohort was divided into training and test datasets at an 8:2 ratio, and class imbalance was mitigated through random oversampling.
Results
Among various models, logistic regression demonstrated the highest predictive performance, with an area under the receiver operating characteristic curve (AUC) of 0.708, which was consistent with the AUC obtained in external validation (0.669). Importantly, the outcomes were robust to missing data imputation and variable selection. The SHapley Additive exPlanations (SHAP) algorithm enhanced the explainability of the model, identifying advancing age, being male, Helicobacter pylori infection, current smoking, and a family history of GC as key predictors of elevated risk.
Conclusion
This predictive model could significantly contribute to the early identification of individuals at elevated risk for GC, thereby enabling the implementation of targeted preventive strategies. Furthermore, the integration of noninvasive and cost-effective predictors enhances the clinical utility of the model, supporting its potential application in routine healthcare settings.

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Development and validation of a prediction model for myelosuppression in lung cancer patients after platinum-based doublet chemotherapy: a multifactorial analysis approach
Xueyan Li
American Journal of Cancer Research.2025; 15(2): 470. CrossRef

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Gastrointestinal cancer

Functional Annotation and Gene Set Analysis of Gastric Cancer Risk Loci in a Korean Population: Hyojin Pyun, Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Joohon Sung, Jeongseon Kim; Cancer Res Treat. 2024;56(1):191-198. Published online June 20, 2023; DOI: https://doi.org/10.4143/crt.2022.958

Abstract PDF Supplementary Material PubReader ePub

Purpose
We aimed to identify the associated single nucleotide polymorphisms (SNPs) with gastric cancer (GC) risk by genome-wide association study (GWAS) and to explore the pathway enrichment of implicated genes and gene-sets with expression patterns.
Materials and Methods
The study population was comprised of 1,253 GC cases and 4,827 controls from National Cancer Center and an urban community of the Korean Genome Epidemiology Study and their genotyping was performed. SNPs were annotated, and mapped to genes to prioritize by three mapping approaches by functional mapping and annotation (FUMA). The gene-based analysis and gene-set analysis were conducted with full GWAS summary data using MAGMA. Gene-set pathway enrichment test with those prioritized genes were performed.
Results
In GWAS, rs2303771, a nonsynonymous variant of KLHDC4 gene was top SNP associated significantly with GC (odds ratio, 2.59; p=1.32×10^–83). In post-GWAS, 71 genes were prioritized. In gene-based GWAS, seven genes were under significant p < 3.80×10^–6 (0.05/13,114); DEFB108B had the lowest p=5.94×10^–15, followed by FAM86C1 (p=1.74×10^–14), PSCA (p=1.81×10^–14), and KLHDC4 (p=5.00×10^–10). In gene prioritizing, KLDHC4 was the only gene mapped with all three gene-mapping approaches. In pathway enrichment test with prioritized genes, FOLR2, PSCA, LY6K, LYPD2, and LY6E showed strong enrichment related to cellular component of membrane; a post-translation modification by synthesis of glycosylphosphatidylinositol (GPI)-anchored proteins pathway.
Conclusion
While 37 SNPs were significantly associated with the risk of GC, genes involved in signaling pathways related to purine metabolism and GPI-anchored protein in cell membrane are pinpointed to be playing important role in GC.

Citations

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A rare KLHDC4 variant Glu510Lys is associated with genetic susceptibility and promotes tumor metastasis in nasopharyngeal carcinoma
Xi-Xi Cheng, Guo-Wang Lin, Ya-Qing Zhou, Yi-Qi Li, Shuai He, Yang Liu, Yan-Ni Zeng, Yun-Miao Guo, Shu-Qiang Liu, Wan Peng, Pan-Pan Wei, Chun-Ling Luo, Jin-Xin Bei
Journal of Genetics and Genomics.2025; 52(4): 559. CrossRef
Investigating the Shared Genetic Architecture Between Leukocyte Telomere Length and Prostate Cancer
Zhizhou Li, Maoyu Wang, Shuxiong Zeng, Ziwei Wang, Yidie Ying, Qing Chen, Chen Zhang, Wei He, Chaoyang Sheng, Yi Wang, Zhensheng Zhang, Chuanliang Xu, Huiqing Wang
The World Journal of Men's Health.2024;[Epub] CrossRef

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Genome-Wide Association of Genetic Variation in the PSCA Gene with Gastric Cancer Susceptibility in a Korean Population: Boyoung Park, Sarah Yang, Jeonghee Lee, Hae Dong Woo, Il Ju Choi, Young Woo Kim, Keun Won Ryu, Young-Il Kim, Jeongseon Kim; Cancer Res Treat. 2019;51(2):748-757. Published online September 5, 2018; DOI: https://doi.org/10.4143/crt.2018.162

Abstract PDF Supplementary Material PubReader ePub

Purpose
Half of the world’s gastric cancer cases and the highest gastric cancer mortality rates are observed in Eastern Asia. Although several genome-wide association studies (GWASs) have revealed susceptibility genes associated with gastric cancer, no GWASs have been conducted in the Korean population, which has the highest incidence of gastric cancer.
Materials and Methods
We performed genome scanning of 450 gastric cancer cases and 1,134 controls via Affymetrix Axiom Exome 319 arrays, followed by replication of 803 gastric cancer cases and 3,693 healthy controls.
Results
We showed that the rs2976394 in the prostate stem cell antigen (PSCA) gene is a gastriccancer-susceptibility gene in a Korean population, with genome-wide significance and an odds ratio (OR) of 0.70 (95% confidence interval [CI], 0.64 to 0.77). A strong linkage disequilibrium with rs2294008 was also found, indicating an association with susceptibility. Individuals with the CC genotype of the PSCA gene showed an approximately 2-fold lower risk of gastric cancer compared to those with the TT genotype (OR, 0.47; 95% CI, 0.39 to 0.57). The effect of the PSCA gene on gastric cancer was more prominent in the female population and for diffuse type gastric cancer.
Conclusion
Our result confirmed that the PSCA gene may be the most important susceptibility gene for gastric cancer risk in a Korean population.

Citations

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Functional Annotation and Gene Set Analysis of Gastric Cancer Risk Loci in a Korean Population
Hyojin Pyun, Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Joohon Sung, Jeongseon Kim
Cancer Research and Treatment.2024; 56(1): 191. CrossRef
HiChIP-Based Epigenomic Footprinting Identifies a Promoter Variant of UXS1 That Confers Genetic Susceptibility to Gastroesophageal Cancer
Ansley Gnanapragasam, Eftyhios Kirbizakis, Anna Li, Kyle H. White, Katelyn L. Mortenson, Juliana Cavalcante de Moura, Wajih Jawhar, Yifei Yan, Reilly Falter, Colleen Russett, Betty Giannias, Sophie Camilleri-Broët, Nicholas Bertos, Jonathan Cools-Lartigue
Cancer Research.2024; 84(14): 2377. CrossRef
High Polygenic Risk Scores Positively Associated with Gastric Cancer Risk Interact with Coffee and Polyphenol Intake and Smoking Status in Korean Adults
Meiling Liu, Sang-Shin Song, Sunmin Park
Nutrients.2024; 16(19): 3263. CrossRef
Dietary mercury intake, the IL23R rs10889677 polymorphism, and the risk of gastric cancer in a Korean population: a hospital-based case-control study
Ji Hyun Kim, Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jeongseon Kim
Epidemiology and Health.2024; 46: e2024051. CrossRef
SNP-SNP Interactions and Gastric Cancer Susceptibility in Ardabil Province
Homa Akhavan Aghghaleh, Najmeh Ranji, Hadi Habibollahi
Journal of Ardabil University of Medical Sciences.2024; 24(3): 364. CrossRef
Interaction between dietary potassium intake and TNF-α rs1800629 genetic polymorphism in gastric cancer risk: a case–control study conducted in Korea
Tao Thi Tran, Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jeongseon Kim
British Journal of Nutrition.2023; 130(5): 887. CrossRef
Rare variants confer shared susceptibility to gastrointestinal tract cancer risk
Ji Zheng, Xin Wang, Jingrao Li, Yuanna Wu, Jiang Chang, Junyi Xin, Meilin Wang, Tianpei Wang, Qingyi Wei, Mengyun Wang, Ruoxin Zhang
Frontiers in Oncology.2023;[Epub] CrossRef
The association of dietary fibre intake and the IL13 rs20541 polymorphism with the risk of gastric cancer: a case-control study in Korea
Tao Thi Tran, Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jeongseon Kim
European Journal of Clinical Nutrition.2022; 76(7): 1031. CrossRef
Systematic review of gastric cancer-associated genetic variants, gene-based meta-analysis, and gene-level functional analysis to identify candidate genes for drug development
Sangjun Lee, Han-Kwang Yang, Hyuk-Joon Lee, Do Joong Park, Seong-Ho Kong, Sue K. Park
Frontiers in Genetics.2022;[Epub] CrossRef
Incidence of Hereditary Gastric Cancer May Be Much Higher than Reported
Paula Baraúna de Assumpção, Paulo Pimentel de Assumpção, Fabiano Cordeiro Moreira, Ândrea Ribeiro-dos-Santos, Amanda F. Vidal, Leandro Magalhães, André Salim Khayat, André Maurício Ribeiro-dos-Santos, Giovanna C. Cavalcante, Adenilson Leão Pereira, Inácio
Cancers.2022; 14(24): 6125. CrossRef
Enhancing the Trajectories of Cancer Health Disparities Research: Improving Clinical Applications of Diversity, Equity, Inclusion, and Accessibility
Rachel Martini, Endale Gebregzabher, Lisa Newman, Melissa B. Davis
Cancer Discovery.2022; 12(6): 1428. CrossRef
Identification of Novel Susceptible Genes of Gastric Cancer Based on Integrated Omics Data
Huang Yaoxing, Yu Danchun, Sun Xiaojuan, Jiang Shuman, Yan Qingqing, Jia Lin
Frontiers in Cell and Developmental Biology.2021;[Epub] CrossRef
The Associations of Dietary Iron Intake and the Transferrin Receptor (TFRC) rs9846149 Polymorphism with the Risk of Gastric Cancer: A Case–Control Study Conducted in Korea
Tao Thi Tran, Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jeongseon Kim
Nutrients.2021; 13(8): 2600. CrossRef
Integration of GWAS and eQTL Analysis to Identify Risk Loci and Susceptibility Genes for Gastric Cancer
Jing Ni, Bin Deng, Meng Zhu, Yuzhuo Wang, Caiwang Yan, Tianpei Wang, Yaqian Liu, Gang Li, Yanbing Ding, Guangfu Jin
Frontiers in Genetics.2020;[Epub] CrossRef
Evolutionary History of the Risk of SNPs for Diffuse-Type Gastric Cancer in the Japanese Population
Risa L. Iwasaki, Koji Ishiya, Hideaki Kanzawa-Kiriyama, Yosuke Kawai, Jun Gojobori, Yoko Satta
Genes.2020; 11(7): 775. CrossRef
TNF genetic polymorphism (rs1799964) may modify the effect of the dietary inflammatory index on gastric cancer in a case–control study
Jeeeun Kim, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Joohon Sung, Jeongseon Kim
Scientific Reports.2020;[Epub] CrossRef
Prediction of gastric cancer risk: association between ZBTB20 genetic variance and gastric cancer risk in Chinese Han population
Fei Bai, Ke Xiao
Bioscience Reports.2020;[Epub] CrossRef
Incidence of Stomach and Esophageal Cancers in Mongolia: Data from 2009 to 2018
Tsegmed Sambuu, Nasanjargal Tumurbat, Bayar Davaa, Bolor-Erdene Tudev
Euroasian Journal of Hepato-Gastroenterology.2020; 10(1): 16. CrossRef

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Effects of Soy Product Intake and Interleukin Genetic Polymorphisms on Early Gastric Cancer Risk in Korea: A Case-Control Study: Sarah Yang, Yoon Park, Jeonghee Lee, Il Ju Choi, Young Woo Kim, Keun Won Ryu, Joohon Sung, Jeongseon Kim; Cancer Res Treat. 2017;49(4):1044-1056. Published online January 19, 2017; DOI: https://doi.org/10.4143/crt.2016.515

Abstract PDF Supplementary Material PubReader ePub

Purpose
The current study investigated whether the combined effects of soy intake and genetic polymorphisms of interleukin (IL) genes modify gastric cancer risk.
Materials and Methods
A total of 377 cases and 754 controls of Korean origin were included in the analysis. Soy consumption was assessed using a semi-quantitative food frequency questionnaire. Seven variants of IL10 (rs1800871), IL2 (rs2069763 and rs2069762), IL13 (rs6596090 and rs20541), and IL4R(rs7205663 and rs1805010) were genetically analyzed. To analyze the combined effect of soy intake and genetic polymorphisms, a low-intake group and high-intake group of each type of soy were categorized based on the intake level of the control group. Interactions between soy products and these genetic variants were analyzed by a likelihood ratio test, in which a multiplicative interaction term was added to the logistic regression model.
Results
A higher intake of nonfermented soy products was associated with a reduced cancer risk (odds ratio [OR], 0.62; 95% confidence interval [CI], 0.43 to 0.90), and the reduced risk was only apparent in males (OR, 0.44; 95% CI, 0.27 to 0.71). None of the IL genetic polymorphisms examined were independently associated with gastric cancer risk. Individuals with a minor allele of IL2 rs2069762 and a higher intake of nonfermented soy food had a decreased risk of gastric cancer (OR, 0.46; 95% CI, 0.31 to 0.68) compared to those with a lower intake (p_interaction=0.039).
Conclusion
Based on the genetic characteristics of the studied individuals, the interaction between IL2 rs2069762 and nonfermented soy intake may modify the risk of gastric cancer.

Citations

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Polyphenol intake and gastric cancer: A case-control study in the Brazilian Amazon region
Marcela de Araújo Fagundes, Renata Alves Carnauba, Gisele Aparecida Fernandes, Paulo Pimentel de Assumpção, Maria Paula Curado
Cancer Epidemiology.2024; 88: 102518. CrossRef
Oral Microbiota as a Diagnostic Biomarker of Digestive Cancer: A Systematic Review
SK Aziz Ikbal, Surendra Kumar Yadav, Roopanshi Mehrotra, Tasneem Fatima, Anjusha Sharda, Srashti Gupta
The Journal of Contemporary Dental Practice.2024; 24(11): 902. CrossRef
The pertinence of gastric cancer and interleukin 10–819 single nucleotide polymorphisms: a meta-analysis and systematic review
Qianqian Mao, Yanwen Liu, Xi Chen, Cheng Jiang Liu
BMC Gastroenterology.2024;[Epub] CrossRef
Soy Product Consumption and the Risk of Cancer: A Systematic Review and Meta-Analysis of Observational Studies
Chenting Wang, Keqing Ding, Xuanzhen Xie, Jinyue Zhou, Pengju Liu, Shuang Wang, Ting Fang, Guozhang Xu, Chunlan Tang, Hang Hong
Nutrients.2024; 16(7): 986. CrossRef
Interaction between dietary potassium intake and TNF-α rs1800629 genetic polymorphism in gastric cancer risk: a case–control study conducted in Korea
Tao Thi Tran, Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jeongseon Kim
British Journal of Nutrition.2023; 130(5): 887. CrossRef
Association between soy products, fruits, vegetables, and dairy products and gastric cancer risk in Helicobacter pylori-infected subjects: a case-control study in Korea
Jung Hyun Kwak, Chang Soo Eun, Dong Soo Han, Yong Sung Kim, Kyu Sang Song, Bo Youl Choi, Hyun Ja Kim
Nutrition Research and Practice.2023; 17(1): 122. CrossRef
Dietary intake and cancer incidence in Korean adults: a systematic review and meta-analysis of observational studies
Ji Hyun Kim, Shinyoung Jun, Jeongseon Kim
Epidemiology and Health.2023; 45: e2023102. CrossRef
The association of dietary fibre intake and the IL13 rs20541 polymorphism with the risk of gastric cancer: a case-control study in Korea
Tao Thi Tran, Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jeongseon Kim
European Journal of Clinical Nutrition.2022; 76(7): 1031. CrossRef
Dietary Polyphenol Intake and Gastric Cancer: A Systematic Review and Meta-Analysis
Marcela de Araújo Fagundes, Alex Richard Costa Silva, Gisele Aparecida Fernandes, Maria Paula Curado
Cancers.2022; 14(23): 5878. CrossRef
Sex-dependent associations between MAP3K1 gene polymorphisms and soy products with the gastric cancer risk in Korea: a case-control study
Jung Hyun Kwak, Chang Soo Eun, Dong Soo Han, Yong Sung Kim, Kyu Sang Song, Bo Youl Choi, Hyun Ja Kim
BMC Gastroenterology.2022;[Epub] CrossRef
Dietary patterns and gastric cancer risk in a Korean population: a case–control study
Ji Hyun Kim, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jeongseon Kim
European Journal of Nutrition.2021; 60(1): 389. CrossRef
Possible Roles of Interleukin-4 and -13 and Their Receptors in Gastric and Colon Cancer
Xujun Song, Benno Traub, Jingwei Shi, Marko Kornmann
International Journal of Molecular Sciences.2021; 22(2): 727. CrossRef
The association between soy‐based food and soy isoflavone intake and the risk of gastric cancer: a systematic review and meta‐analysis
Yameng Wang, Jiaping Guo, Fei Yu, Yongmei Tian, Yongjun Wu, Lingling Cui, Li‐e Liu
Journal of the Science of Food and Agriculture.2021; 101(13): 5314. CrossRef
The Associations of Dietary Iron Intake and the Transferrin Receptor (TFRC) rs9846149 Polymorphism with the Risk of Gastric Cancer: A Case–Control Study Conducted in Korea
Tao Thi Tran, Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jeongseon Kim
Nutrients.2021; 13(8): 2600. CrossRef
Identification of Dietary Pattern Networks Associated with Gastric Cancer Using Gaussian Graphical Models: A Case-Control Study
Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jeongseon Kim
Cancers.2020; 12(4): 1044. CrossRef
Genome‐wide profiling of normal gastric mucosa identifies Helicobacter pylori‐ and cancer‐associated DNA methylome changes
Hae Dong Woo, Nora Fernandez‐Jimenez, Akram Ghantous, Davide Degli Esposti, Cyrille Cuenin, Vincent Cahais, Il Ju Choi, Young‐Il Kim, Jeongseon Kim, Zdenko Herceg
International Journal of Cancer.2018; 143(3): 597. CrossRef
The association between dietary isoflavones intake and gastric cancer risk: a meta-analysis of epidemiological studies
Jie You, Yafei Sun, Yacong Bo, Yiwei Zhu, Dandan Duan, Han Cui, Quanjun Lu
BMC Public Health.2018;[Epub] CrossRef

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Effect of Helicobacter pylori Eradication on Long-Term Survival after Distal Gastrectomy for Gastric Cancer: Young-Il Kim, Soo-Jeong Cho, Jong Yeul Lee, Chan Gyoo Kim, Myeong-Cherl Kook, Keun Won Ryu, Young-Woo Kim, Il Ju Choi; Cancer Res Treat. 2016;48(3):1020-1029. Published online November 17, 2015; DOI: https://doi.org/10.4143/crt.2015.264

Abstract PDF PubReader ePub

Purpose
Negative Helicobacter pylori status has been identified as a poor prognostic factor for survival in gastric cancer (GC) patients who underwent surgery. The aim of this study was to examine the effect of H. pylori eradication on long-term outcomes after distal gastrectomy for GC.
Materials and Methods
We analyzed the survival of 169 distal GC patients enrolled in a prospective randomized trial evaluating histologic changes of gastric mucosa after H. pylori eradication in the remnant stomach. The outcomes measured were overall survival (OS) and GC recurrence rates.
Results
The median follow-up duration was 9.4 years. In the modified intention-to-treat analysis including patients who underwent H. pylori treatment (n=87) or placebo (n=82), 5-year OS rates were 98.9% in the treatment group and 91.5% in the placebo group, and KaplanMeier analysis showed no significant difference in OS (p=0.957) between groups. In multivariate analysis, no difference in overall mortality was observed between groups (adjusted hazard ratio [aHR] for H. pylori treatment, 0.75; p=0.495) or H. pylori-eradicated status (aHR for positive H. pylori status, 1.16; p=0.715), while old age, male sex, and advanced stage ≥ IIIa were independent risk factors. Six patients in the treatment group (6.9%) and seven patients in the placebo group (8.5%) had GC recurrences, and GC recurrence rates were not different according to H. pylori treatment (5-year GC recurrence rates, 4.6% in the treatment group vs. 8.5% in the placebo group; p=0.652).
Conclusion
H. pylori eradication for GC patients who underwent distal gastrectomy did not compromise long-term survival after surgery.

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Relationship between Helicobacter pylori infection and programmed death-ligand 1 in gastric cancer: A meta-analysis
Hong-Chang Yang, Cheng-Feng Fu, Li-Jun Qiao, Gen-He Long, Li-Fen Yang, Biao Yao
World Journal of Clinical Oncology.2025;[Epub] CrossRef
The relationship between the eradication of Helicobacter pylori and the occurrence of stomach cancer: an updated meta-analysis and systemic review
Zhouhan Wu, Yi Tang, Meiwen Tang, Zhoutong Wu, Yonghui Xu
BMC Gastroenterology.2025;[Epub] CrossRef
Anti–Helicobacter pylori Treatment in Patients With Gastric Cancer After Radical Gastrectomy
Zhoukai Zhao, Ruopeng Zhang, Guoming Chen, Man Nie, Feiyang Zhang, Xiaojiang Chen, Jun Lin, Zewei Chen, Feizhi Lin, Chengzhi Wei, Ziqi Zheng, Shenghang Ruan, Bowen Huang, Yingbo Chen, Runcong Nie
JAMA Network Open.2024; 7(3): e243812. CrossRef
Helicobacter Pylori and Celiac Disease Antibody Positivity Have a Higher Prevalence in Patients With Distal Gastrectomy: A Cross-Sectional Retrospective Study
Kubilay Issever, Ersin Kuloglu, Demet Sengul, Ali Muhtaroglu, Ahmet Cumhur Dulger
Cureus.2023;[Epub] CrossRef
The influence of partial gastrectomy for gastric cancer on the spontaneous disappearance of Helicobacter pylori: A single‐center prospective study
Senichiro Yanagawa, Nobuaki Fujikuni, Kazuaki Tanabe, Masahiro Nakahara, Toshio Noriyuki
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Positive H. pylori status predicts better prognosis of non-cardiac gastric cancer patients: results from cohort study and meta-analysis
Zhifang Jia, Min Zheng, Jing Jiang, Donghui Cao, Yanhua Wu, Yuzheng Zhang, Yingli Fu, Xueyuan Cao
BMC Cancer.2022;[Epub] CrossRef
Effect of gastric cancer screening on long-term survival of gastric cancer patients: results of Korean national cancer screening program
Xuan Quy Luu, Kyeongmin Lee, Jae Kwan Jun, Mina Suh, Kyu-Won Jung, Kui Son Choi
Journal of Gastroenterology.2022; 57(7): 464. CrossRef
Current Evidence for a Paradigm Shift in Gastric Cancer Prevention From Endoscopic Screening toHelicobacter pyloriEradication in Korea
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Journal of Gastric Cancer.2022; 22(3): 169. CrossRef
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Kentaro Matsuo, Sang-Woong Lee, Ryo Tanaka, Yoshiro Imai, Kotaro Honda, Kohei Taniguchi, Hideki Tomiyama, Kazuhisa Uchiyama
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Yonghoon Choi, Nayoung Kim, Chang Yong Yun, Yoon Jin Choi, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Sang-Hoon Ahn, Do Joong Park, Hye Seung Lee, Ji-Won Kim, Jin Won Kim, Keun-Wook Lee, Won Chang, Ji Hoon Park, Yoon Jin Lee, Kyoung Ho Lee, Young Hoon Kim
Gastric Cancer.2020; 23(6): 1051. CrossRef
Impact of the timing of Helicobacter pylori eradication on the risk of development of metachronous lesions after treatment of early gastric cancer: a population-based cohort study
Hyun Ju Kim, Yun Jin Kim, Seung In Seo, Woon Geon Shin, Chan Hyuk Park
Gastrointestinal Endoscopy.2020; 92(3): 613. CrossRef
Helicobacter pylori Eradication in Patients Undergoing Gastrectomy: Diagnosis and Therapy
Youn I Choi, Jun-Won Chung
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2020; 20(3): 204. CrossRef
Helicobacter pylori Eradication in Adult Patients with Acute Idiopathic Thrombocytopenic Purpura (ITP)
Minoosh Moghimi, Yousef Mortazavi, Saeed Razavi-Dizaji, Shahrbanoo Keyhanian, Zahra Ghadimi, Sahar Baba Ali, Saeideh Mazloomzadeh, Sattar Jafari, Reza Mansouri, Masoud Asadi-Khiavi
Journal of Advances in Medical and Biomedical Research.2019; 27(124): 1. CrossRef
Helicobacter pylori Therapy for the Prevention of Metachronous Gastric Cancer
Il Ju Choi, Myeong-Cherl Kook, Young-Il Kim, Soo-Jeong Cho, Jong Yeul Lee, Chan Gyoo Kim, Boram Park, Byung-Ho Nam
New England Journal of Medicine.2018; 378(12): 1085. CrossRef
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Gastroenterology Research and Practice.2018; 2018: 1. CrossRef
Do We Need to Retest of Helicobacter pylori Infection after Gastric Cancer Surgery?
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Gut and Liver.2017; 11(2): 169. CrossRef

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Long-Term Low-Dose Aspirin Use Reduces Gastric Cancer Incidence: A Nationwide Cohort Study: Young-Il Kim, So Young Kim, Ji Hyun Kim, Jun Ho Lee, Young-Woo Kim, Keun Won Ryu, Jong-Hyock Park, Il Ju Choi; Cancer Res Treat. 2016;48(2):798-805. Published online July 14, 2015; DOI: https://doi.org/10.4143/crt.2015.117

Abstract PDF PubReader ePub

Purpose
The aim of this study was to investigate whether aspirin use can reduce the incidence of gastric cancer in patients with hypertension or type 2 diabetes. Materials and Methods A total of 200,000 patients with hypertension or type 2 diabetes were randomly selected from the Korean National Health Insurance claim database. Of these, 3,907 patients who used 100 mg of aspirin regularly (regular aspirin users) and 7,808 patients who did not use aspirin regularly (aspirin non-users) were selected at a frequency of 1:2, matched by age, sex, comorbid illnesses (type 2 diabetes and hypertension), and observation periods. The incidence of gastric cancer in this cohort was then assessed during the observation period of 2004 to 2010.
Results
In the matched cohort, the incidence rates of gastric cancer were 0.8% (31/3,907) for regular aspirin users and 1.1% (86/7,808) for aspirin non-users, but the cumulative incidence rates were not significantly different between groups (p=0.116, log-rank test). However, in multivariate analysis, regular aspirin users had a reduced risk of gastric cancer (adjusted hazard ratio [aHR], 0.71; 95% confidential interval [CI], 0.47 to 1.08; p=0.107). Duration of aspirin use showed significant association with reduction of gastric cancer risk (aHR for each year of aspirin use, 0.85; 95% CI, 0.73 to 0.99; p=0.044), particularly in patients who used aspirin for more than 3 years (aHR, 0.40; 95% CI, 0.16 to 0.98; p=0.045). Conclusion Long-term low-dose aspirin use was associated with reduced gastric cancer risk in patients with hypertension or type 2 diabetes.

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Exposure to Commonly Used Drugs and the Risk of Gastric Cancer: An Umbrella Review of Meta-Analyses
Xiao Bai, Si-Qi Ding, Xue-Ping Zhang, Ming-Hao Han, Dong-Qiu Dai
Cancers.2023; 15(2): 372. CrossRef
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Effects of Polymorphisms of Innate Immunity Genes and Environmental Factors on the Risk of Noncardia Gastric Cancer: Jeongseon Kim, Young Ae Cho, Il Ju Choi, Yeon-Su Lee, Sook-Young Kim, Jung-Ah Hwang, Soo-Jeong Cho, Myeong-Cherl Kook, Chan Gyoo Kim, Young-Woo Kim; Cancer Res Treat. 2013;45(4):313-324. Published online December 31, 2013; DOI: https://doi.org/10.4143/crt.2013.45.4.313

Abstract PDF PubReader ePub

PURPOSE
Increasing evidence suggests that polymorphisms in innate immunity genes are associated with Helicobacter pylori-induced inflammation and may influence susceptibility in developing noncardia gastric cancer. Therefore, we investigate the effect of polymorphisms of innate immunity genes and interactions with environmental factors in the Korean population.
MATERIALS AND METHODS
We genotyped four polymorphisms of TLR2 (rs1898830), TLR4 (rs10983755 and rs10759932), and CD14 (rs2569190) in a case-control study of 487 noncardia gastric cancer patients and 487 sex- and age-matched healthy controls. Polytomous logistic regression models were used to detect the effects of genetic polymorphisms and environmental factors, which were stratified by the histological type of gastric cancer.
RESULTS
TLR4 rs10983755 A carriers were found to have higher risk of intestinal-type noncarida gastric cancer than G homozygotes (odds ratio [OR], 1.41; 95% confidence interval [CI], 1.01 to 1.97), but other genetic variants showed no association with the risk of noncardia gastric cancer. Among H. pylori-positive participants, smokers carrying TLR4 rs10983755 A had a higher risk of intestinal-type gastric cancer than nonsmoking TLR4 rs10983755 G homozygotes (OR, 4.28; 95% CI, 2.12 to 8.64). In addition, compared with tap water, other drinking water sources during childhood were found to be associated with the elevated risk of intestinal-type gastric cancer, and these associations were slightly stronger among TLR4 rs10983755 A carriers.
CONCLUSION
The genetic polymorphisms of innate immunity genes are associated with the development of intestinal-type noncardia gastric cancer and these associations may differ in accordance to an exposure to certain environmental factors.

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