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2 "Eun Hyo Jin"
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Gastrointestinal cancer
The Persistence of Hypertriglyceridemia and the Risk of Early Onset Colorectal Cancer According to Tumor Subsites: A Nationwide Population-Based Study
Young Hoon Chang, Cheol Min Shin, Kyungdo Han, Jin Hyung Jung, Eun Hyo Jin, Joo Hyun Lim, Seung Joo Kang, Yoon Jin Choi, Hyuk Yoon, Young Soo Park, Nayoung Kim, Dong Ho Lee
Cancer Res Treat. 2024;56(3):825-837.   Published online December 20, 2023
DOI: https://doi.org/10.4143/crt.2023.753
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
The incidence of early-onset colorectal cancer (EoCRC) is increasing worldwide. The association between hypertriglyceridemia (HTG) and EoCRC risk remains unclear.
Materials and Methods
We conducted a nationwide cohort study of 3,340,635 individuals aged 20-49 years who underwent health checkups between 2009 and 2011 under the Korean National Health Insurance Service. HTG was defined as serum triglyceride (TG) level ≥ 150 mg/dL. According to the change in TG status, participants were categorized into persistent normotriglyceridemia (NTG; group 1), NTG to HTG (group 2), HTG to NTG (group 3), and persistent HTG (group 4) groups. The EoCRC incidence was followed up until 2019.
Results
In total, 7,492 EoCRC cases developed after a mean of 6.05 years of follow-up. Group 4 had the highest risk of EoCRC (adjusted hazard ratio [aHR], 1.097; 95% confidence interval [CI], 1.025 to 1.174). While the risk of rectal cancer was significantly increased in groups 3 and 4 (aHR [95% CI], 1.236 [1.076 to 1.419] and 1.175 [1.042-1.325], respectively), no significant risk differences were observed in right colon cancer. In group 4, male sex and diabetes were associated with a further increased risk of EoCRC (aHR [95% CI], 1.149 [1.082 to 1.221] and 1.409 [1.169 to 1.699], respectively). In addition, there was a dose-response relationship between serum TG levels and the risk of EoCRC (p for trends < 0.0001).
Conclusion
Persistent HTG increased the risk of EoCRC, which was significantly higher only for rectal cancer and marginally higher for other colonic subsites.

Citations

Citations to this article as recorded by  
  • Obesity-Associated Colorectal Cancer
    Lucia Gonzalez-Gutierrez, Omar Motiño, Daniel Barriuso, Juan de la Puente-Aldea, Lucia Alvarez-Frutos, Guido Kroemer, Roberto Palacios-Ramirez, Laura Senovilla
    International Journal of Molecular Sciences.2024; 25(16): 8836.     CrossRef
  • 2,849 View
  • 106 Download
  • 1 Web of Science
  • 1 Crossref
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Association between the Persistence of Obesity and the Risk of Gastric Cancer: A Nationwide Population-Based Study
Joo Hyun Lim, Cheol Min Shin, Kyung-Do Han, Seung Woo Lee, Eun Hyo Jin, Yoon Jin Choi, Hyuk Yoon, Young Soo Park, Nayoung Kim, Dong Ho Lee
Cancer Res Treat. 2022;54(1):199-207.   Published online May 4, 2021
DOI: https://doi.org/10.4143/crt.2021.130
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
There remains controversy about relationship between obesity and gastric cancer. We aimed to examine the association using obesity-persistence.
Materials and Methods
We analyzed a nationwide population-based cohort which underwent health check-up between 2009 and 2012. Among them, those who had annual examinations during the last 5 years were selected. Gastric cancer risk was compared between those without obesity during the 5 years (never-obesity group) and those with obesity diagnosis during the 5 years (non-persistent obesity group; persistent obesity group).
Results
Among 2,757,017 individuals, 13,441 developed gastric cancer after median 6.78 years of follow-up. Gastric cancer risk was the highest in persistent obesity group (incidence rate [IR], 0.89/1,000 person-years; hazard ratio [HR], 1.197; 95% confidence interval [CI], 1.117 to 1.284), followed by non-persistent obesity group (IR, 0.83/1,000 person-years; HR, 1.113; 95% CI, 1.056 to 1.172) compared with never-obesity group. In subgroup analysis, this positive relationship was true among those < 65 years old and male. Among heavy-drinkers, the impact of obesity-persistence on the gastric cancer risk far increased (non-persistent obesity: HR, 1.297; 95% CI, 1.094 to 1.538; persistent obesity: HR, 1.351; 95% CI, 1.076 to 1.698).
Conclusion
Obesity-persistence is associated with increased risk of gastric cancer in a dose-response manner, especially among male < 65 years old. The risk raising effect was much stronger among heavy-drinkers.

Citations

Citations to this article as recorded by  
  • Diagnosis of gastric cancer in role of endoscopic imaging techniques in artificial intelligence and machine learning applications: An overview
    Pooja K., Kishore Kanna R., G. Li, U. Subramaniam, M. Sekar
    E3S Web of Conferences.2024; 491: 03016.     CrossRef
  • Joint association of drinking alcohol and obesity in relation to cancer risk: A systematic review and data synthesis
    Graeme A. Macdonald, James A. Thomas, Christine Dalais, Bradley J. Kendall, Aaron P. Thrift
    Cancer Epidemiology.2024; 91: 102596.     CrossRef
  • Roles of long non‑coding RNA SNHG16 in human digestive system cancer (Review)
    Lujie Zhao, Yuling Kan, Lu Wang, Jiquan Pan, Yun Li, Haiyan Zhu, Zhongfa Yang, Lin Xiao, Xinhua Fu, Fujun Peng, Haipeng Ren
    Oncology Reports.2024;[Epub]     CrossRef
  • Gastric Cancer Risk in Association with Underweight, Overweight, and Obesity: A Systematic Review and Meta-Analysis
    Narges Azizi, Moein Zangiabadian, Golnoosh Seifi, Afshan Davari, Elham Yekekhani, Seyed Amir Ahmad Safavi-Naini, Nathan A. Berger, Mohammad Javad Nasiri, Mohammad-Reza Sohrabi
    Cancers.2023; 15(10): 2778.     CrossRef
  • Recent research progress on the correlation between metabolic syndrome and Helicobacter pylori infection
    Qinli Xie, Yangjun He, Danni Zhou, Yi Jiang, Ying Deng, Ruoqing Li
    PeerJ.2023; 11: e15755.     CrossRef
  • Risk of gastric cancer in relation with serum cholesterol profiles: A nationwide population-based cohort study
    Mi Jin Oh, Kyungdo Han, Bongseong Kim, Joo Hyun Lim, Bokyung Kim, Sang Gyun Kim, Soo-Jeong Cho
    Medicine.2023; 102(48): e36260.     CrossRef
  • Decreasing Incidence of Gastric Cancer with Increasing Time after Helicobacter pylori Treatment: A Nationwide Population-Based Cohort Study
    Taewan Kim, Seung In Seo, Kyung Joo Lee, Chan Hyuk Park, Tae Jun Kim, Jinseob Kim, Woon Geon Shin
    Antibiotics.2022; 11(8): 1052.     CrossRef
  • Integration of clinical and transcriptomics reveals programming of the lipid metabolism in gastric cancer
    Yanyan Li, Jungang Zhao, Renpin Chen, Shengwei Chen, Yilun Xu, Weiyang Cai
    BMC Cancer.2022;[Epub]     CrossRef
  • Body fatness associations with cancer: evidence from recent epidemiological studies and future directions
    Susanna C. Larsson, Nikolaos Spyrou, Christos S. Mantzoros
    Metabolism.2022; 137: 155326.     CrossRef
  • FOXC2-AS1 stabilizes FOXC2 mRNA via association with NSUN2 in gastric cancer cells
    Jijun Yan, Juntao Liu, Zhengbin Huang, Wenwei Huang, Jianfa Lv
    Human Cell.2021; 34(6): 1755.     CrossRef
  • 7,405 View
  • 249 Download
  • 9 Web of Science
  • 10 Crossref
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