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2 "Dong Ki Kim"
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Lung Cancer
Clinical Significance of Acute Kidney Injury in Lung Cancer Patients
Semin Cho, Eunjeong Kang, Ji Eun Kim, U Kang, Hee Gyung Kang, Minsu Park, Kwangsoo Kim, Dong Ki Kim, Kwon Wook Joo, Yon Su Kim, Hyung-Jin Yoon, Hajeong Lee
Cancer Res Treat. 2021;53(4):1015-1023.   Published online January 18, 2021
DOI: https://doi.org/10.4143/crt.2020.1010
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
Acute kidney injury (AKI) in cancer patients is associated with increased morbidity and mortality. The incidence of AKI in lung cancer seems to be relatively higher compared with other solid organ malignancies, although its impact on patient outcomes remains unclear.
Materials and Methods
The patients newly diagnosed with lung cancer from 2004 to 2013 were enrolled in this retrospective cohort study. The patients were categorized according to the presence and severity of AKI. We compared all-cause mortality and long-term renal outcome according to AKI stage.
Results
A total of 3,202 patients were included in the final analysis. AKI occurred in 1,783 (55.7%) patients during the follow-up period, with the majority having mild AKI stage 1 (75.8%). During the follow-up of 2.6±2.2 years, total 1,251 patients (53.7%) were died and 5-year survival rate was 46.9%. We found that both AKI development and severity were independent risk factors for all-cause mortality in lung cancer patients, even after adjustment for lung cancer-specific variables including the stage or pathological type. In addition, patients suffered from more severe AKI tend to encounter de novo chronic kidney disease development, worsening kidney function, and end-stage kidney disease progression.
Conclusion
In this study, more than half of the lung cancer patients experienced AKI during their diagnosis and treatment period. Moreover, AKI occurrence and more advanced AKI were associated with a higher mortality risk and adverse kidney outcomes.

Citations

Citations to this article as recorded by  
  • Acute kidney injury associated with anti-PD-1 and anti-PD-L1 drugs: a meta-analysis of randomized clinical trials
    Isabela Gonçalves Lima, Isabele Benck Usiro Cabral da Silva, Vitória Carpentieri Pípolo, Vinicius Daher Alvares Delfino, Paulo Roberto Bignardi
    Immunopharmacology and Immunotoxicology.2024; 46(4): 470.     CrossRef
  • Prevalence of kidney disease in patients with different types of cancer or hematological malignancies: a cross-sectional study
    Feng Wu, Shiyuan Wang, Jialing Zhang, Peixin Wang, Aihua Zhang
    International Urology and Nephrology.2024; 56(12): 3835.     CrossRef
  • Protective effect of reduced glutathione on acute kidney injury in lung cancer patients treated with cisplatin: a retrospective cohort study
    Ying Huang, Yang Li, Xialian Xu, Jie Teng, Xiaoqiang Ding, Jiarui Xu
    Renal Failure.2024;[Epub]     CrossRef
  • Association between renal dysfunction and outcomes of lung cancer: A systematic review and meta‑analysis
    Huijuan Qian, Si Li, Ziyun Hu
    Oncology Letters.2024;[Epub]     CrossRef
  • Association and prediction of red blood cell distribution width to albumin ratio in all-cause mortality of acute kidney injury in critically ill patients
    Chen Gao, Longkai Peng
    Frontiers in Medicine.2023;[Epub]     CrossRef
  • Point of care ultrasonography in onco-nephrology: A stride toward better physical examination
    Bhavna Bhasin-Chhabra, Abhilash Koratala
    World Journal of Nephrology.2023; 12(2): 29.     CrossRef
  • Protocolo diagnóstico y tratamiento de la nefropatía en los pacientes con neoplasia sólida
    Rodríguez Doyágüez, M.P. Morán Magro, C.M. Durán López, P. Martínez Miguel
    Medicine - Programa de Formación Médica Continuada Acreditado.2023; 13(82): 4870.     CrossRef
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Establishment of a Screenig Test System for Early Diagnosis of Hepatocellular Carcinoma in High-Risk Patients and the Evaluation of Its Effectiveness
Kwang Hyub Han, Sang Hoon Ahn, Dong Ki Kim, Ki Joon Song, Jung Il Jeong, Kwan Sik Lee, Jae Bock Chung, Chae Yoon Chon, Young Myoung Moon, Il Suh, Jung Mo Nam
J Korean Cancer Assoc. 2000;32(6):1084-1092.
AbstractAbstract PDF
PURPOSE
To evaluate the effectiveness of clinic-based screening program for early detection of hepatocellular carcinoma (HCC) and to assess the risk factors of HCC in Korea.
MATERIALS AND METHODS
The data of 14,259 patients who had ultrasonography (US) due to chronic liver diseases were collected into a data base program from 1990 to 1998.
RESULTS
A total of 4,339 patients were enrolled who had repeated US. 237 patients were diagnosed as HCC during follow-up (mean 33 months). The tumor size detected by screening within a 6-months interval was significantly smaller than that of a longer interval (2.7 cm vs 3.9 cm, P<0.01). The smaller the tumor was at detection, the longer the survival time was. Only 29.9% of HCC patients had an elevated serum alpha-fetoprotein (alphaFP) level above 400 ng/ml. Multivariate analysis showed liver cirrhosis, chronic hepatitis B or C and old age over 40 years to be significantly associated with an increased risk of HCC.
CONCLUSION
The US screening within a 6-months interval is beneficial to high-risk patients over 40 years old through the early detection of HCC and prolonged survival. According to the risk factors, the necessity for screening test and proper interval should be reconsidered.
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  • 19 Download
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