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J Korean Cancer Assoc > Volume 32(1); 2000 > Article
Journal of the Korean Cancer Association 2000;32(1): 60-67.
Expression Pattern and Prognostic Correlation of BAG - 1 Protein in Breast Cancer
Se Hoon Cho, Dae Young Lee, Byung Jin Kim, Sook Hee Hong
1Departments of Surgery, Dong-A University College of Medicine, Busan, Korea.
2Departments of Anatomical Pathology, Dong-A University College of Medicine, Busan, Korea.
The objective of this study was to understand the expression of BAG-1 in the human breast cancer.
We studied its expression in one hundred and thirteen patients diagnosed with breast cancer in Dong-A university hospital between 1992 and 1996 by performing immunohistochemical staining with BAG-1 monoclonal antibody.
Of the 113 breast carcinoma examined, 62.0% were positive for BAG-1 cyto- plasmic expression, 28.0% were positive for nuclear BAG-1 expression and 9.7% were positive for both BAG-1 cytoplasmic and nuclear expression. The higher histologic grade was correlated with the higher cytoplasmic expression (p<0.05). Except for histologic grade, no correlation was observed between BAG-1 expression and conventional prognostic factors such as age, menopausal status, metastatic status of the axillary lymh nodes, cathepsin-D, p53, C-erbB-2, DNA ploidy, S-phase fraction, PCNA (proliferating cell nuclear antigen).
The high histologic grade was found to correlate with positive BAG-1 cyto- plasmic staining which did not correlate with conventional prognostic factors. Our data indicate that furthermore investigation is warranted to define the role of BAG-1 as an meaningful prognostic factor in patients with newly diagnosed breast cancer.
Key words: Breast neoplasm;BAG-1
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