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J Korean Cancer Assoc > Volume 32(3); 2000 > Article
Journal of the Korean Cancer Association 2000;32(3): 487-496.
Clinicopathologic Significance of Multidrug Resistance Protein Expression in Patients with Stage III Gastric Adendegrees Carcinoma
Sae Hyun Kim, Wan Ku Lee, Hyun Kim, Young Nam Kim, Seung Min Park, Su Jin Choi, Hyo Suk Park, Myung Jin Joo, Kwang Min Lee, Jong Myung Lee, Sung Hye Shin, Min Chul Kim
1Departments of Hemato-Oncology, Presbyterian Medical Center, Chonju, Korea.
2Departments of Anatomical Patholgy, Presbyterian Medical Center, Chonju, Korea.
3Departments of General Surgery, Presbyterian Medical Center, Chonju, Korea.
4Departments of Christian Medical Research Center, Presbyterian Medical Center, Chonju, Korea.
ABSTRACT
PURPOSE:
We wanted to determine the prognostic significance of P-glycoprotein (Pgp) and multi drug resistance-assdegrees Ciated protein (MRP) in stage III gastric adendegrees Carcinoma by evaluating whe ther the Pgp and/or MRP expression correlate with various clinicopathological parameters and survival rates. MATERIAL AND
METHODS:
The expression of Pgp and/or MRP were studied immunohistdegrees Chemi cally by ABC method with paraffin-embedded tissue specimens which were surgically obtained from 64 cases of stage III gastric adendegrees Carcinomas at the Department of Surgery, Presbyterian Medical Center from 1991 to 1992. Statistical differences of both expression in various factors including survival rates and clinicopatholgical parameters were sought.
RESULTS:
Expression rates of Pgp and MRP group were 50.0% and 43.7% respectively. There was no significant correlation between expression of two proteins and various clinicopathological variables such as age, sex, stage, tumor depth, number of metastatic node, tumor size, site and method of operation. However, in case of the degree of differenciation, the expression of Pgp and/or MRP was significantly greater in well differenciated adendegrees Carcinoma than in poorly dif ferenciated adendegrees Carcinoma (p=0.001, p=0.012). Statistically, no significant correlations between the expression of Pgp and/or MRP and overall survival rates were found.
CONCLUSION:
These results suggest that the Pgp and/or MRP expression in patients with stage III gastric adendegrees Carcinomas are not useful in determining postoperative chemotherapy and as an independent predictor of survival.
Key words: Stomach neoplasm;Multidrug resistance;P-glycoprotein
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