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Original Article
- Vascular Endothelial Growth Factor and basic Fibroblast Growth Factor Expression in Early Gastric Carcinomas: Correlation with Clinicopathologic Factors
- Young Sik Kim, Hyun Deuk Cho, Seong Hwan Park, Dae Won Kim, Dae Su Kim, Jong Sang Choi, Hwa Eun Oh
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Journal of the Korean Cancer Association 2000;32(6): 986-996.
1College of Medicine, Kwandong University, Myongji Hospital, Koyang, Korea.
2Department of Pathology, College of Medicine, Korea University, Seoul, Korea.
2Department of Pathology, College of Medicine, Korea University, Seoul, Korea.
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Abstract
PURPOSE
Recent studies have demonstrated that angiogenesis and its inducers such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) play an important role in growth, progression, and metastasis in gastric carcinomas. In this study, the authors investigated the prognostic significance of angiogenesis, VEGF, bFGF with respect to conventional clinicopathologic factors in early gastric adenocarcinomas.
MATERIALS AND METHODS
Sixty-six specimens resected from patients with early gastric carcinomas were investigated by immunohistochemical staining with antibodies against VEGF, bFGF, and CD31.
RESULTS
In this study, high expression rates of VEGF and bFGF as well as high level of angiogenesis were observed. In addition, the expression rate of VEGF was correlated well with angiogenesis. However, the clinicopathologic factors, such as age, sex, location, growth pattern, lymph node metastasis, submucosal invasion, and degree of differentiation, were not significantly associated with the expression of VEGF and bFGF, and angiogenesis.
CONCLUSION
These results suggest that controlling angiogenesis and its inducers might be a therapeutic target rather than a prognostic factor in early gastric carcinomas.
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