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J Korean Cancer Assoc > Volume 32(6); 2000 > Article
Journal of the Korean Cancer Association 2000;32(6): 1100-1108.
C-erbB-2 Protein Expression and Correlation in Sera and Tumors of Non-Small Cell Lung Cancer Patients
Hun Mo Ryoo, Sang Yeop Lee, Kyung Hee Lee, Myung Soo Hyun, Mi Jin Kim
1Departments of Internal Medicine, Yeung Nam University College of Medicine, Daegu, Korea. rhmrhm@cuth.cataegu.ac.kr
2Departments of Anatomical Pathology, Yeung Nam University College of Medicine, Daegu, Korea.
We have examined the expression of c-erbB-2 oncogene in sera and tissues of non-small cell lung cancer patients.
Serum levels of c-erbB-2 protein were measured by an enzyme im munoassay in 55 patients with non-small cell lung cancer. Sera from patients with surgical therapy were evaluated again after surgery. Immunohistochemical staining was performed in 47 of these tumors.
Elevated levels (> or =45 U/mL, control mean 2SD) were observed in 15% of 55 non-small cell lung cancer patients, as compared with none of control subjects (p<0.05). The incidence of elevated level was higher in the adenocarcinoma than squamous cell carcinoma (22% vs 4%, p<0.01). The serum levels of c-erbB-2 protein decreased significantly after surgical tumor ablation (p<0.01). Tissue overexpression was obtained in 23/47 cases (49%). The incidence of c-erbB-2 overexpression was higher in the adenocarcinoma (73% vs 29%, p<0.005). No relationship was found between c-erbB-2 protein expression in serum and tumor tissue and clinicopathologic feature. Elevated serum c-erbB-2 levels predicted tissue overexpression with sensitivity 30% and specificity 96%. There was relationship between serum level and expression in tumor tissue of c-erbB-2 protein.
Serum and tissue levels of c-erbB-2 correlate in patients with non-small cell carcinoma. Serum c-erbB-2 protein may be a useful indicator of tumor burden in patients with non-small cell lung cancer.
Key words: Non-small cell lung cancer;C-erbB-2;Gene
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