Skip Navigation
Skip to contents

Cancer Res Treat : Cancer Research and Treatment

Search
Advanced Search
OPEN ACCESS
mobile search button mobile menu button

Articles

Page Path
HOME > J Korean Cancer Assoc > Volume 33(1); 2001 > Article
Original Article
Interaction between Genetic Polymorphisms of CYP2E1 & NAT1 and Smoking in Lung Cancer Development (Preliminary report)
Kyoung Mu Lee, Seung Joon Lee, Sue Kyung Park, Sang Yun Lee, Hyung June Im, Ki Jung Yoon, In Mi Choi, Young Ju Lee, Soo Ung Kim, Hwang Choi, Seung Ho Choi, Young Whan Kim, Soo Han Cho, Daehee Kang
Journal of the Korean Cancer Association 2001;33(1): 41-48.
1Department of Preventive Medicine, Seoul National University College of Medicine, Korea.
2Department of Internal Medicine, Hallym University College of Medicine, Korea.
3Department of Preventive Medicine, Dogguk University College of Medicine, Korea.
4Institute of Environmental Medicine, Seoul National University Medical Research Center, Korea.
5Department of Urology, Seoul National University College of Medicine, Seoul, Korea.
6Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
  • 3,603 Views
  • 25 Download
  • 0 Crossref
  • 0 Scopus
prev next
Full Article

Download PDF Download PDF

Abstract

PURPOSE
The interactive effects of genetic polymorphisms of cytochrome P4502E1 (CYP2E1) & N-acetyltransferase 1 (NAT1) and smoking on lung cancer development were evaluated in hospital based case-control study.
MATERIALS AND METHODS
Male lung cancer patients (N= 157) and the male patients with no present or previous history of systemic illnesses who visited the urology department (N=138) were recruited (1998-1999). CYP2E1 & NAT1 genotypes were determined by PCR-RFLP method using RsaI and MboII digestion, respectively.
RESULTS
CYP2E1 c2 or NAT1 *10 allele did not increased the risk of lung cancer. Heavy smokers (35CONCLUSION
These results suggest the gene-environment interaction between genetic polymorphisms of CYP2E1 & NAT1 and smoking in lung cancer development.

  • Cite
    CITE
    export Copy Download
    Close
    Download Citation
    Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.
    Format:
    • RIS — For EndNote, ProCite, RefWorks, and most other reference management software
    • BibTeX — For JabRef, BibDesk, and other BibTeX-specific software
    Include:
    • Citation for the content below
    Interaction between Genetic Polymorphisms of CYP2E1 & NAT1 and Smoking in Lung Cancer Development (Preliminary report)
    J Korean Cancer Assoc. 2001;33(1):41-48.
    Close
Cancer Res Treat : Journal of the Korean Cancer Association
© Korean Cancer Association.
Close layer
TOP