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Cancer Research and Treatment > Volume 34(1); 2002 > Article
Cancer Research and Treatment 2002;34(1): 52-57. doi: https://doi.org/10.4143/crt.2002.34.1.52
Expression of Cell Surface Receptors on Human Glioblastoma Xenograft Model in NOD/SCID Mouse
Kyung Seung Oh, Ki Uk Kim, Na Hee Park, Su Yeong Seo, Sun Seob Choi, Gi Yeong Huh
1Department of Diagnostic Radiology, Kosin University Collegeof Medicine, Busan, Korea.
2Department of Neurosurgery, Dong-A University College ofMedicine, Busan, Korea.
3Department of Microbiology, Dong-A University College ofMedicine, Busan, Korea.
4Department of Diagnostic Radiology, Dong-A UniversityCollege of Medicine, Busan, Korea.
5Department of Pathology, Dong-A University College ofMedicine, Busan, Korea. gyhuh@daunet.donga.ac.kr
  Published online: February 28, 2002.
ABSTRACT
PURPOSE:
To obtain basic data for development of a glioblastoma-specific immunotoxin, the expression of variable cell surface receptors on a human glioblastoma xenograft model was evaluated, using NOD/SCID mice.
MATERIALS AND METHODS:
We developed a xenograft model in NOD/SCID mice implanted with a human glioblastoma cell line (U-87MG). Immunohistochemical studies were performed on implanted tumor nodules (n=8) using antibodies against CD71, EGFR, IGF-IRalpha, CXCR4 and IL-4Ralpha.
RESULTS:
Expression of IL-4Ralpha, in implanted tumornodules, was the highest of the cell surface receptors evaluated in this study. However, the endothelial cells in, and around, the tumor nodules also revealed immunopositivity against IL-4Ralpha. The immunoreactivity of IL-4Ralpha, and other surface receptors such as CD71, IGF-IRalpha and EGFR, was prominent in tumor nodules associated with tumor necrosis.
CONCLUSION:
IL-4Ralpha would be a possible target for the development of glioblastoma-specific immunotoxin, although there are limitations due to its endothelial expression.
Key words: Glioblastoma;Interleukin-4 receptor;SCID mouse
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