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Cancer Research and Treatment > Volume 35(2); 2003 > Article
Cancer Research and Treatment 2003;35(2): 130-134. doi: https://doi.org/10.4143/crt.2003.35.2.130
Prognosis of Malignant Obstructive Jaundice Following Surgery for Gastric Carcinoma
Jae Hyun Song, Ki Young Yoon, Sang Ho Lee
Department of Surgery, Gospel Hospital, Kosin MedicalCollege, Busan, Korea. gssong@kosin.md
  Published online: April 30, 2003.
Obstructive jaundice is a rare presentation, but is an ominous prognostic sign in patients undergoing surgery for a gastric carcinoma. Therefore, we investigated the prognosis of malignant obstructive jaundice following surgery for a gastric carcinoma.
Thirty-eight patients, with an extrahepatic biliary obstruction due to a metastatic gastric carcinoma, were retrospectively studied to determine their demographics, clinical features, laboratory finding, pathological characteristics and survival.
Between January 1996 and April 2000, 2401 patients underwent operations for gastric cancer, of which 38 (1.6%) were found to have obstructive jaundice. The mean age was 55.9 +/- 10.7 years, and the sex ratio (male: female) was 3.2: 1. The median interval between the previous gastrectomy and the presentation of jaundice was 10.1 8.9 months. The levels of total bilirubin and direct bilirubin were 16.5 +/- 6.5 and 12.0 +/- 4.4, respectively. The most common site of the obstruction was the common bile duct (65%). An antrumal location, poorly differentiated stage IV gastric cancer was common associated with obstructive jaundice. A percutaneous transhepatic biliary drainage was a commonly used treatment modality. When the clinical and laboratory findings were presented to a Cox regression analysis, the P values of the time interval and albumin were 0.019 and 0.057, respectively.
The time interval between a previous gastrectomy, the presentation of jaundice and albumin level were found to be independent risk factors for predicting the survival.
Key words: Stomach neoplasm;Obstructive jaundice
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