Neoadjuvant Cisplatin-Based Chemotherapy Followed by Selective Bladder Preservation Chemoradiotherapy in Muscle-Invasive Urothelial Carcinoma of the Bladder: Post Hoc Analysis of Two Prospective Studies

Sung Wook Cho; Sung Hee Lim; Ghee Young Kwon; Chan Kyo Kim; Won Park; Hongryull Pyo; Jae Hoon Chung; Wan Song; Hyun Hwan Sung; Byong Chang Jeong; Se Hoon Park

doi:10.4143/crt.2024.015

Articles

Page Path: HOME > Cancer Res Treat > Volume 56(3); 2024 > Article

Original Article Genitourinary cancer Neoadjuvant Cisplatin-Based Chemotherapy Followed by Selective Bladder Preservation Chemoradiotherapy in Muscle-Invasive Urothelial Carcinoma of the Bladder: Post Hoc Analysis of Two Prospective Studies: Sung Wook Cho¹, Sung Hee Lim¹, Ghee Young Kwon², Chan Kyo Kim³, Won Park⁴, Hongryull Pyo⁴, Jae Hoon Chung⁵, Wan Song⁵, Hyun Hwan Sung⁵, Byong Chang Jeong⁵, Se Hoon Park¹; Cancer Research and Treatment : Official Journal of Korean Cancer Association 2024;56(3):893-897.
DOI: https://doi.org/10.4143/crt.2024.015
Published online: February 15, 2024

¹Division of Hematology and Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

²Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

³Department of Radiology and Center for Imaging Sciences, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

⁴Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

⁵Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

Correspondence: Se Hoon Park, Division of Hematology and Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea
Tel: 82-2-3410-1779 Fax: 82-2-3410-1754 E-mail: hematoma@skku.edu

• Received: January 4, 2024 • Accepted: February 13, 2024

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

7,125 Views
226 Download
6 Web of Science
7 Crossref
8 Scopus

prev next

Full Article

Download PDF

Abstract

Purpose
Bladder preservation chemoradiotherapy (CRT) in patients with a clinical complete response (cCR) following cisplatin-based neoadjuvant chemotherapy (NAC) is a promising treatment strategy for muscle-invasive bladder urothelial carcinoma (MIBC). A combined analysis of raw data from two prospective phase II studies was performed to better evaluate the feasibility of selective bladder preservation CRT.
Materials and Methods
The analysis was based on primary efficacy data from two independent studies, including 76 MIBC patients receiving NAC followed by bladder preservation CRT. The efficacy data included metastasis-free survival (MFS) and disease-free survival (DFS). For the present analysis, starting point of survival was defined as the date of commencing CRT.
Results
Among 76 patients, 66 had a cCR following NAC. Sixty-four patients received gemcitabine and cisplatin (GC) combination chemotherapy in neoadjuvant setting, and 12 received nivolumab plus GC. Bladder preservation CRT following NAC was generally well-tolerated, with low urinary tract symptoms being the most common late complication. With a median follow-up of 64 months, recurrence was recorded in 43 patients (57%): intravesical only (n=20), metastatic only (n=16), and both (n=7). In 27 patients with intravesical recurrence, transurethral resection, and Bacillus Calmette-Guerin treatment was given to 17 patients. Salvage cystectomy was performed in 10 patients. Median DFS was 46.3 (95% confidence interval [CI], 25.1 to 67.5) months, and the median MFS was not reached. Neither DFS nor MFS appeared to be affected by any of the baseline characteristics. However, DFS was significantly longer in patients with a cCR than in those without (hazard ratio, 0.465; 95% CI, 0.222 to 0.976).
Conclusion
The strategy of NAC followed by selective bladder preservation CRT based on the cCR is feasible in the treatment of MIBC. A standardized definition of cCR is needed to better assess disease status post-NAC.
Key words: Urinary bladder neoplasms, Muscle-invasive, Neoadjuvant chemoradiotherapy

Introduction

Urothelial carcinoma (UC), also termed transitional cell carcinoma, arising from urinary bladder is the second most frequently occurring genitourinary malignancy after prostate cancer, and is one of the main causes of cancer death in Korea [1]. Bladder UC presents as superficial (i.e., non-muscle-invasive), muscle-invasive (MIBC), or metastatic disease. In patients with MIBC, cisplatin-based neoadjuvant chemotherapy (NAC) followed by radical cystectomy and bilateral pelvic lymphadenectomy has been considered the standard treatment [2]. Studies have revealed that NAC results in substantial tumor downstaging (15%-30% pathologic complete response [pCR]), and thus prolonged survival in patients with MIBC [3-5].

Although radical cystectomy remains the standard of care for MIBC, some patients are not candidates for curative surgery due to advanced age, poor performance status, or multiple comorbidities. In addition, radical surgery and urinary diversion significantly affect patient quality of life [6]. Thus, bladder preservation chemoradiotherapy (CRT) may be offered to non-surgical candidates who are medically unfit to undergo radical surgery, or to those who refuse bladder removal. Although bladder preservation strategies involving radiotherapy with or without chemotherapy have often been perceived to result in inferior overall survival (OS) compared with radical cystectomy, no randomized trials support this bias. Five-year disease-free survival (DFS) rates of 61% to 71%, and 5-year OS rates ranging from 30% to 70% have been achieved in appropriately selected patients with modern bladder preservation approaches [7,8]. Treatment decisions should be based on patient preference and an understanding of the quality of life issues associated with radical surgery.

With the introduction of a multidisciplinary team approach in the treatment of MIBC, treatment decision-making has become more complex given the multiple specialties involved in delivering different components of treatment. Since 2017, we performed two prospective, open-label clinical trials involving NAC for patients with MIBC [9,10]. In these two consecutive trials, patients who achieved a clinical complete response (cCR) were offered bladder preservation CRT. Because of the long-term follow-up and the increased number of patients, the present combined analyses could be useful to identify factors predicting durable DFS, and to provide an evidence-based recommendation for the selection of treatment strategy for MIBC according to the cCR after NAC.

Materials and Methods

The present study was performed using data obtained from two consecutive phase II trials evaluating NAC for MIBC: gemcitabine and cisplatin (GC; Clinicaltrials.gov, NCT030-61630) [9] and nivolumab plus GC (ONO-4538-X41; CRIS. nih.go.kr, KCT0003804) [10]. Both prospective trials were conducted in accordance with Good Clinical Practice and the Declaration of Helsinki. Study protocols were approved by the Samsung Medical Center (Seoul, Korea) Institutional Review Board, and all patients provided written informed consent before study entry. Detailed study designs and results have been published previously [9,10], and only data regarding disease recurrence and survival were updated at the time of the present analysis. In both trials, eligible patients with T2-T4aN0M0 MIBC received NAC with GC±nivolumab. Sixty-six patients who achieved cCR post-NAC were eligible to receive bladder preservation CRT. A cCR was evaluated following NAC, and defined as no tumors visible either on imaging studies or on urine cytology and cystoscopy. However, an additional 10 patients without cCR were included because they refused surgery and underwent CRT as an alternative option.

An extensive literature search of clinical trial results, guidelines, and real-world data was performed to identify criteria commonly used to predict higher risk of recurrence and the development of metastases. Endpoints included DFS and metastasis-free survival (MFS). Disease recurrence was defined as no evidence of disease both in the urinary tract (i.e., bladder and upper tract) and distant organs or lymph nodes, and was determined by follow-up imaging studies, urine cytology, and cystoscopy. MFS was defined as the time to the development of metastatic disease. For the present analysis, starting point of survival was set as the date of commencing CRT. Survival curves and their 95% confidence intervals (CIs) were presented according to the Kaplan-Meier method. Analyses for predictive DFS and MFS were performed using the Cox regression model. Variables used to identify predictive factors included age (> vs. < median), sex (male vs. female), T category at the time of study entry (T2 vs. T3/T4a), grade (World Health Organization 2 vs. 3), previous history of intravesical Bacillus Calmette-Guerin (BCG), presence of carcinoma in situ (CIS), multiple primary tumors, status of large (< 5 vs. > 5 cm), presence of hydronephrosis, Eastern Cooperative Oncology Group performance status (0 vs. 1), study treatment (with nivolumab vs. without), and the achievement of cCR following neoadjuvant chemotherapy. Interactions between these variables were represented by products of the corresponding variables. Non-significant variables were dropped one at a time, beginning with the least significant. Statistical tests were performed using the R package (https://www.r-project.org), and the cutoff date for the present analysis was November 2023.

Results

A total of 76 patients treated with NAC followed by bladder preservation CRT were included (Fig. 1). Median time from study enrollment to data cutoff date was 65 months (range, 62 to 68 months) in the GC trial [9], and 44 months (range, 42 to 47 months) in ONO-4538-X41 [10]. Baseline patient characteristics are summarized in Table 1. The median age was 67 years and most (83%) were male. Sixty-six patients (87%) achieved cCR following NAC.

With a median follow-up of 64 months, bladder preservation CRT following NAC was generally well-tolerated, with low urinary tract symptoms being the most common late complication. Severe (grade 3 or 4) complications associated with CRT including intractable bleeding or recurrent infections were noted in eight patients. Disease recurrence was recorded in 43 patients (57%): intravesical only (n=20), metastatic only (n=16), and both (n=7). In 20 patients with intravesical recurrence only (Ta/CIS, n=11; T1, n=8; T2, n=2), transurethral resection and BCG treatment was given to 17 patients. Salvage cystectomy was performed in 10 patients. The most commonly observed metastatic site was the lymph nodes (n=20), followed by lung (n=7), bone (n=5), and liver (n=4). The median DFS was 46.3 months (95% CI, 25.1 to 67.5 months), and the median MFS was not reached (Fig. 2). At 5 years after starting CRT, the DFS and MFS rates were calculated to be 38% and 70%, respectively.

Baseline factors that showed individual predictive value in univariate models were used to examine their joint value in a multivariate model. We found a significant interaction between T category and cCR, suggesting the effect of NAC was higher in T2 than in T3/T4a tumors. In univariate analysis, T category, no BCG history, and cCR were significantly associated with DFS. Multivariate model revealed that DFS was independently associated with cCR (hazard ratio, 0.465; 95% CI, 0.222 to 0.976; p=0.043). In contrast, MFS was not affected by any of the baseline factors (Table 2).

Discussion

The present exploratory post hoc analyses of our two prospective clinical trials demonstrated that bladder preservation CRT in MIBC patients who achieved cCR after NAC is feasible, and provides durable DFS and MFS. With a novel treatment strategy of bladder preservation CRT according to cCR, the 5-year DFS and MFS rates were 38% and 70%, respectively. In 26% of patients with intravesical-only recurrence, the disease could be controlled with transurethral resection or salvage cystectomy. Multivariate analyses revealed that the ideal candidate for bladder preservation CRT is the patient with a cCR following NAC.

Although cisplatin-based NAC followed by radical cystectomy is the current standard of care for patients with MIBC [2-4], the major drawback associated with radical cystectomy is significant morbidities that have profound impact on patient quality of life [6,11]. As noted in the present study, most patients are elderly, which can increase rates of postoperative complications or even impact eligibility to undergo radical surgery. Therefore, a major motivation for bladder preservation following NAC is to avoid complications caused by the removal of bladder and urinary diversion. For example, a pooled analysis of the Radiation Therapy Oncology Group (RTOG) studies involving bladder preservation CRT showed cCR in 69% of patients and low rates of muscleinvasive local failure (14% in 10 years) [12]. If the prognostic value of cCR can be reliably validated as a promising alternative endpoint, accurate determination of cCR would provide a paradigm shift in bladder preservation approaches for the management of MIBC [13]. Unfortunately, studies have demonstrated that cCR after NAC did not necessarily predict pCR based on cystectomy specimens [14,15]. Even with post-NAC transurethral resection and molecular biomarkers [16,17], the false downstaging rate reflects the continuing clinical dilemma of the inability to accurately restage tumor status after NAC. However, these two trials (active surveillance in RETAIN [16] and nivolumab maintenance in HCRN GU16-256 [17]) did not involve local treatment (i.e., CRT) in patients who achieved cCR. The need for salvage cystectomy in a subset of patients with intravesical recurrence raises the need for CRT to further optimize the likelihood of bladder preservation. In addition, patient selection is important for long-term DFS and/or MFS in bladder preservation approaches. Ideal candidates for CRT are patients with small, single tumors that can be completely resected, no CIS, and no hydronephrosis [2]. Perhaps one of the most interesting findings in the present analysis was the observation of similar DFS and MFS irrespective of baseline factors. Although it requires a validation in further studies, if a patient achieves cCR post-NAC, bladder preservation CRT can be considered a reasonable alternative to radical cystectomy.

The limitations of the present study include the nature of post hoc exploratory analyses, and possible selection bias as the two trials had no comparative arms. It is also unclear how the addition of immune checkpoint inhibitors to NAC, either concurrently and/or as maintenance therapy, could impact the rate of cCR [18]. Additionally, some patients with MIBC are cisplatin-ineligible; that population is frequently excluded from clinical trials. More than a few phase III clinical trials are under way in an MIBC neoadjuvant setting, both in cisplatin-eligible (NIAGARA, NCT03732677; ENER-GIZE, NCT03661320, Keynote 866, NCT03924856) and cisplatinineligible (Keynote 905, NCT03924895; VOLGA, NCT04960- 709) patients. For patients who choose bladder preservation and those who are not eligible for cystectomy, trials comparing immune checkpoint inhibitor combinations and CRT (SunRISe-2, NCT04658862) also are ongoing. Questions raised here and in other contemporary trials of MIBC should be addressed by these ongoing trials.

In conclusion, the findings obtained here demonstrate the feasibility and efficacy of the strategy of NAC followed by selective bladder preservation CRT according to the cCR. Although current assessment of cCR lacks validation, and NAC followed by radical cystectomy is still the standard of care in MIBC, bladder preservation CRT may also yield acceptable oncologic outcomes. Considering the substantial perioperative morbidity and the significant effect on patient quality of life, the results from ongoing and future clinical trials will be useful in decision-making among MIBC patients.

NOTES

Ethical Statement

Both prospective trials were conducted in accordance with Good Clinical Practice and the Declaration of Helsinki. Study protocols were approved by the Samsung Medical Center (Seoul, Korea) Institutional Review Board (approval number: SMC IRB No. 2017-01-006 and No. 2017-10-008), and all patients provided written informed consent before study entry.

Author Contributions

Conceived and designed the analysis: Cho SW, Park SH.

Collected the data: Cho SW, Kwon GY, Kim CK, Park W, Pyo H, Chung JH, Song W, Sung HH, Jeong BC, Lim SH.

Contributed data or analysis tools: Cho SW, Kwon GY, Kim CK, Park W, Pyo H, Chung JH, Song W, Sung HH, Jeong BC, Lim SH, Park SH.

Performed the analysis: Cho SW.

Wrote the paper: Cho SW.

Conflicts of Interest

Conflict of interest relevant to this article was not reported.

Fig. 1.

Study flow of the two phase II trials. cCR, clinical complete response; MIBC, muscle-invasive bladder cancer.

Fig. 2.

Kaplan-Meier curves for disease-free and metastasis-free survival.

Table 1.

Baseline patient characteristics

	No. (%)
Age (yr)
Median (range)	67 (40-85)
Sex
Male	63 (82.9)
Female	13 (17.1)
T category
T2	66 (86.8)
T3 or T4a	10 (13.2)
Grade
Moderately-differentiated (G2)	10 (13.2)
Poorly-differentiated (G3)	66 (86.8)
Risk factors
BCG history	17 (22.4)
Presence of CIS	15 (19.7)
Multiple primary tumors	21 (27.6)
Large (> 5 cm) tumor	8 (10.5)
Hydronephrosis	7 (9.2)
ECOG performance status
0	59 (77.6)
1	17 (22.4)
Neoadjuvant chemotherapy regimens
Gemcitabine and cisplatin	64 (84.2)
Gemcitabine and cisplatin, plus nivolumab	12 (15.8)
Clinical complete response after neoadjuvant	66 (86.8)

BCG, Bacillus Calmette-Guerin intravesical therapy; CIS, carcinoma in situ; ECOG, Eastern Cooperative Oncology Group.

Table 2.

Multivariate regression analyses for disease-free and metastasis-free survival

	Disease-free survival		Metastasis-free survival
	HR (95% CI)	p-value	HR (95% CI)	p-value
T2 vs. T3/T4a	0.494 (0.218-1.116)	0.090	0.472 (0.174-1.277)	0.140
No BCG history	0.552 (0.277-1.101)	0.092	0.536 (0.220-1.304)	0.169
Clinical CR	0.465 (0.222-0.976)	0.043	0.615 (0.228-1.656)	0.336

BCG, Bacillus Calmette-Guerin intravesical therapy; CI, confidence interval; CR, complete response; HR, hazard ratio.

REFERENCES

1. Kang MJ, Won YJ, Lee JJ, Jung KW, Kim HJ, Kong HJ, et al. Cancer statistics in Korea: incidence, mortality, survival, and prevalence in 2019. Cancer Res Treat. 2022;54:330–44. Article PubMed PMC PDF
2. Flaig TW, Spiess PE, Agarwal N, Bangs R, Boorjian SA, Buyyounouski MK, et al. Bladder cancer, version 3.2020, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2020;18:329–54. PubMed
3. Grossman HB, Natale RB, Tangen CM, Speights VO, Vogelzang NJ, Trump DL, et al. Neoadjuvant chemotherapy plus cystectomy compared with cystectomy alone for locally advanced bladder cancer. N Engl J Med. 2003;349:859–66. PubMed
4. Galsky MD, Pal SK, Chowdhury S, Harshman LC, Crabb SJ, Wong YN, et al. Comparative effectiveness of gemcitabine plus cisplatin versus methotrexate, vinblastine, doxorubicin, plus cisplatin as neoadjuvant therapy for muscle-invasive bladder cancer. Cancer. 2015;121:2586–93. Article PubMed
5. Peyton CC, Tang D, Reich RR, Azizi M, Chipollini J, Pow-Sang JM, et al. Downstaging and survival outcomes associated with neoadjuvant chemotherapy regimens among patients treated with cystectomy for muscle-invasive bladder cancer. JAMA Oncol. 2018;4:1535–42. Article PubMed PMC
6. Ghosh A, Somani BK. Recent trends in postcystectomy healthrelated quality of life (QoL) favors neobladder diversion: systematic review of the literature. Urology. 2016;93:22–6. Article PubMed
7. James N, Hussain SA. Management of muscle invasive bladder cancer: British approaches to organ conservation. Semin Radiat Oncol. 2005;15:19–27. Article PubMed
8. Kozak KR, Hamidi M, Manning M, Moody JS. Bladder preservation for localized muscle-invasive bladder cancer: the survival impact of local utilization rates of definitive radiotherapy. Int J Radiat Oncol Biol Phys. 2012;83:e197–204. Article PubMed PMC
9. Sung HH, Kim H, Kim R, Kim CK, Kwon GY, Park W, et al. Neoadjuvant chemotherapy with gemcitabine and cisplatin followed by selective bladder preservation chemoradiotherapy in muscle-invasive urothelial carcinoma of bladder. Investig Clin Urol. 2022;63:168–74. Article PubMed PMC PDF
10. Kim H, Jeong BC, Hong J, Kwon GY, Kim CK, Park W, et al. Neoadjuvant nivolumab plus gemcitabine/cisplatin chemotherapy in muscle-invasive urothelial carcinoma of the bladder. Cancer Res Treat. 2023;55:636–42. Article PubMed PMC PDF
11. Madersbacher S, Schmidt J, Eberle JM, Thoeny HC, Burkhard F, Hochreiter W, et al. Long-term outcome of ileal conduit diversion. J Urol. 2003;169:985–90. Article PubMed
12. Mak RH, Hunt D, Shipley WU, Efstathiou JA, Tester WJ, Hagan MP, et al. Long-term outcomes in patients with muscle-invasive bladder cancer after selective bladder-preserving combined-modality therapy: a pooled analysis of Radiation Therapy Oncology Group protocols 8802, 8903, 9506, 9706, 9906, and 0233. J Clin Oncol. 2014;32:3801–9. PubMed PMC
13. Lee HW, Kwon WA, Nguyen NT, Phan DT, Seo HK. Approaches to clinical complete response after neoadjuvant chemotherapy in muscle-invasive bladder cancer: possibilities and limitations. Cancers (Basel). 2023;15:1323.Article PubMed PMC
14. Reese AC, Ball MW, Gandhi N, Gorin MA, Netto GJ, Bivalacqua TJ, et al. The utility of an extensive postchemotherapy staging evaluation in patients receiving neoadjuvant chemotherapy for bladder cancer. Urology. 2014;84:358–63. Article PubMed PMC
15. Becker RE, Meyer AR, Brant A, Reese AC, Biles MJ, Harris KT, et al. Clinical restaging and tumor sequencing are inaccurate indicators of response to neoadjuvant chemotherapy for muscle-invasive bladder cancer. Eur Urol. 2021;79:364–71. PubMed
16. Geynisman DM, Abbosh P, Ross EA, Zibelman MR, Ghatalia P, Anari F, et al. A phase II trial of risk-enabled therapy after initiating neoadjuvant chemotherapy for bladder cancer (RETAIN). J Clin Oncol. 2023;41(6 Suppl):438.Article
17. Galsky MD, Daneshmand S, Izadmehr S, Gonzalez-Kozlova E, Chan KG, Lewis S, et al. Gemcitabine and cisplatin plus nivolumab as organ-sparing treatment for muscle-invasive bladder cancer: a phase 2 trial. Nat Med. 2023;29:2825–34. PubMed PMC
18. Song SH, Oh JJ. The evolving role of checkpoint inhibitors in the treatment of urothelial carcinoma: a literature review of practice-changing trials. J Urol Oncol. 2023;21:154–64. Article PDF

Figure & Data

REFERENCES

Citations

Citations to this article as recorded by

Neoadjuvant Chemotherapy Prior to Trimodality Therapy for Muscle-invasive Bladder Cancer: A Systematic Review and Meta-analysis
Keiichiro Miyajima, Akihiro Matsukawa, Takafumi Yanagisawa, Marcin Miszczyk, Navid Roessler, Shota Inoue, Abdulrahman S. Alqahtani, Ahmed R. Alfarhan, Fumihiko Urabe, Keiichiro Mori, Pierre I. Karakiewicz, Takahiro Kimura, Shahrokh F. Shariat
European Urology Open Science.2026; 83: 54. CrossRef
Comparative Outcomes of Surgery and Chemoradiotherapy After Neoadjuvant Chemotherapy in Stage II–III Bladder Cancer
Doğan Bayram, Öznur Bal, Alper Türkel, Serhat Sekmek, Emre Hafızoğlu, Berkan Karabuga, Mutlu Doğan, Efnan Algın, Doğan Uncu
The European Research Journal.2026; : 160. CrossRef
Bladder Preservation with Concurrent Chemoradiotherapy Following Complete Response to Induction Systemic Therapy in Patients with Muscle-Invasive Bladder Cancer: A Review of the Existing Literature
Georgios Nikiforos Ntoumas, Andromachi Kougioumtzopoulou, Dimitra Desse, Charalambos Fragkoulis, Georgios Papadopoulos, Efthymios Kostouros, Dimitra Michaletou, Vassileios Kouloulias, Anna Zygogianni, Ioannis Georgakopoulos
Cancers.2026; 18(6): 961. CrossRef
Recent Advances and Future Directions in Bladder Preservation Therapy for Muscle‐Invasive Bladder Cancer
Tomokazu Kimura, Satoshi Inoue, Tomoyasu Sano, Kenji Zennami, Shusuke Akamatsu
International Journal of Urology.2025; 32(10): 1334. CrossRef
Prognostic Factors of Trimodal Therapy for Muscle-invasive Bladder Cancer: A Systematic Review and Meta-analysis
Keiichiro Miyajima, Akihiro Matsukawa, Takafumi Yanagisawa, Marcin Miszczyk, Navid Roessler, Shota Inoue, Shingo Nishimura, Abdulrahman S. Alqahtani, Ahmed R. Alfarhan, Fumihiko Urabe, Keiichiro Mori, Pierre I. Karakiewicz, Leonardo Oliveira Reis, Takahir
European Urology Focus.2025;[Epub] CrossRef
Assessing clinical complete response after neoadjuvant systemic therapy in muscle-invasive bladder cancer: a systematic review
Navid Roessler, Marcin Miszczyk, Paolo Gontero, Keiichiro Miyajima, Shota Inoue, Ahmed R. Alfarhan, Abdulrahman S. Alqahtani, Markus von Deimling, Malte W. Vetterlein, Jeremy Yuen-Chun Teoh, David D’Andrea, Margit Fisch, Shahrokh F. Shariat
World Journal of Urology.2025;[Epub] CrossRef
News and prospects on radiotherapy for bladder cancer: Is trimodal therapy becoming the gold standard?
Olivier Riou, Christophe Hennequin, Jonathan Khalifa, Paul Sargos
Cancer/Radiothérapie.2024; 28(6-7): 623. CrossRef

PubReader
ePub Link

Cite

CITE: export Copy Download Format; Close

Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

Format:

RIS — For EndNote, ProCite, RefWorks, and most other reference management software
BibTeX — For JabRef, BibDesk, and other BibTeX-specific software

Include:

Citation for the content below
Citation and abstract for the content below

Neoadjuvant Cisplatin-Based Chemotherapy Followed by Selective Bladder Preservation Chemoradiotherapy in Muscle-Invasive Urothelial Carcinoma of the Bladder: Post Hoc Analysis of Two Prospective Studies

Cancer Res Treat. 2024;56(3):893-897. Published online February 15, 2024

DOI: https://doi.org/10.4143/crt.2024.015

XML Download

Abstract
Introduction
Materials and Methods
Results
Discussion
NOTES
REFERENCES

Fig. 1. Study flow of the two phase II trials. cCR, clinical complete response; MIBC, muscle-invasive bladder cancer.

Fig. 2. Kaplan-Meier curves for disease-free and metastasis-free survival.

Fig. 1.

Fig. 2.

	No. (%)
Age (yr)
Median (range)	67 (40-85)
Sex
Male	63 (82.9)
Female	13 (17.1)
T category
T2	66 (86.8)
T3 or T4a	10 (13.2)
Grade
Moderately-differentiated (G2)	10 (13.2)
Poorly-differentiated (G3)	66 (86.8)
Risk factors
BCG history	17 (22.4)
Presence of CIS	15 (19.7)
Multiple primary tumors	21 (27.6)
Large (> 5 cm) tumor	8 (10.5)
Hydronephrosis	7 (9.2)
ECOG performance status
0	59 (77.6)
1	17 (22.4)
Neoadjuvant chemotherapy regimens
Gemcitabine and cisplatin	64 (84.2)
Gemcitabine and cisplatin, plus nivolumab	12 (15.8)
Clinical complete response after neoadjuvant	66 (86.8)

	Disease-free survival		Metastasis-free survival
	HR (95% CI)	p-value	HR (95% CI)	p-value
T2 vs. T3/T4a	0.494 (0.218-1.116)	0.090	0.472 (0.174-1.277)	0.140
No BCG history	0.552 (0.277-1.101)	0.092	0.536 (0.220-1.304)	0.169
Clinical CR	0.465 (0.222-0.976)	0.043	0.615 (0.228-1.656)	0.336

Table 1. Baseline patient characteristics

BCG, Bacillus Calmette-Guerin intravesical therapy; CIS, carcinoma in situ; ECOG, Eastern Cooperative Oncology Group.

Table 2. Multivariate regression analyses for disease-free and metastasis-free survival

BCG, Bacillus Calmette-Guerin intravesical therapy; CI, confidence interval; CR, complete response; HR, hazard ratio.