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Cancer Research and Treatment > Epub ahead of print
doi: https://doi.org/10.4143/crt.2020.424    [Epub ahead of print]
An Innovative Prognostic Model Based on Four Genes in Asian Patient with Gastric Cancer
Jiahui Chen1, Anqiang Wang1, Jun Ji2,3, Kai Zhou1, Zhaode Bu1, Guoqing Lyu4, Jiafu Ji1
1Department of Gastrointestinal Surgery, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China
2Department of Gastrointestinal Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China
3First Affiliated Hospital of Baotou Medical College, General Surgery, Baotou, China
4Department of Gastrointestinal Surgery, Peking University Shenzhen Hospital, Shenzhen, China
Correspondence  Guoqing Lyu ,Tel: 86-0755-83923333 , Fax: 86-0755-83061340 , Email: 365973269@qq.com
Jiafu Ji ,Tel: 86-10-88196970, Fax: 86-10-88196970, Email: jijiafu@hsc.pku.edu.cn
Received: May 8, 2020;  Accepted: August 28, 2020.  Published online: August 31, 2020.
*Jiahui Chen, Anqiang Wang and Jun Ji contributed equally to this work.
ABSTRACT
Purpose
Gastric cancer (GC) has substantial biological differences between Asian and non-Asian populations, which makes it difficult to have a unified predictive measure for all people. We aimed to identify novel prognostic biomarkers to help predict the prognosis of Asian GC patients.
Materials and Methods
We investigated the differential gene expression between GC and normal tissues of GSE66229. Univariate, multivariate and Lasso Cox regression analyses were conducted to establish a four-gene-related prognostic model based on the risk score. The risk score was based on a linear combination of the expression levels of individual genes multiplied by their multivariate Cox regression coefficients. Validation of the prognostic model was conducted using The Cancer Genome Atlas (TCGA) database. A nomogram containing clinical characteristics and the prognostic model was established to predict the prognosis of Asian GC patients.
Results
Four genes (RBPMS2, RGN, PLEKHS1, and CT83) were selected to establish the prognostic model, and it was validated in the TCGA Asian cohort. Receiver operating characteristic analysis confirmed the sensitivity and specificity of the prognostic model. Based on the prognostic model, a nomogram containing clinical characteristics and the prognostic model was established, and Harrell’s concordance index of the nomogram for evaluating the overall survival significantly higher than the model only focuses on the pathologic stage (0.74 vs. 0.64, p < 0.001).
Conclusion
The four-gene-related prognostic model and the nomogram based on it are reliable tools for predicting the overall survival of Asian GC patients.
Key words: Stomach neoplasms, Overall survival, Prognostic model, Risk score, Nomograms
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