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HOME > Cancer Res Treat > Volume 51(4); 2019 > Article
Original Article Temsirolimus in Asian Metastatic/Recurrent Non-clear Cell Renal Carcinoma
Jii Bum Lee, MD1,2, Hyung Soon Park, MD, PhD3, Sejung Park, MS4, Hyo Jin Lee, MD, PhD5, Kyung A Kwon, MD, PhD6, Young Jin Choi, MD7, Yu Jung Kim, MD, PhD8, Chung Mo Nam, PhD9, Nam Hoon Cho, MD, PhD10, Beodeul Kang, MD1,2,11, Hyun Cheol Chung, MD, PhD1,2,11, Sun Young Rha, MD, PhD1,2,11,
Cancer Research and Treatment : Official Journal of Korean Cancer Association 2019;51(4):1578-1588.
DOI: https://doi.org/10.4143/crt.2018.671
Published online: April 16, 2019

1Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea

2Song-Dang Institute for Cancer Research, Yonsei University College of Medicine, Seoul, Korea

3Division of Medical Oncology, Department of Internal Medicine, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea

4Department of Biostatistics, Yonsei University College of Medicine, Seoul, Korea

5Department of Internal Medicine, Chungnam National University, Daejeon, Korea

6Division of Hematology-Oncology, Department of Internal Medicine, Dongnam Institute of Radiological and Medical Sciences, Busan, Korea

7Division of Hematology-Oncology, Pusan National University, Busan, Korea

8Division of Hematology and Medical Oncology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea

9Department of Preventive Medicine and Institute of Health Services Research, Yonsei University College of Medicine, Seoul, Korea

10Division of Pathology, Yonsei University College of Medicine, Seoul, Korea

11Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea

Correspondence: Sun Young Rha, MD, PhD Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea
Tel: 82-2-2228-8053 Fax: 82-2-362-5592 E-mail: rha7655@yuhs.ac
• Received: December 3, 2018   • Accepted: April 8, 2019

Copyright © 2019 by the Korean Cancer Association

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • Purpose
    Temsirolimus is effective in the treatment for metastatic non-clear cell renal cell carcinoma (nccRCC) with poor prognosis. We aim to investigate the efficacy and tolerability of temsirolimus in treatment of naïve Asian patients with metastatic/recurrent nccRCC.
  • Materials and Methods
    From January 2008 to July 2017, data of treatment-naïve, metastatic/recurrent nccRCC patients, who were treated with temsirolimus according to the standard protocol, were collected. The primary end-point was progression-free survival (PFS). Secondary end points were overall survival (OS), objective response rate (ORR), and tolerability of temsirolimus.
  • Results
    Forty-four metastatic/recurrent nccRCC patients, 10 from prospective and 34 from retrospective groups, were enrolled; 24 patients (54%) were papillary type, and other histology subtypes included 11 chromophobes (25%), two collecting ducts (5%), one Xp11.2 translocation (2%), and six others (14%). The median PFS and OS were 7.6 months and 17.6 months, res-pectively. ORR was 11% and disease control rate was 83%. Patients with prior nephrectomy had longer PFS (hazard ratio [HR], 0.16; 95% confidence interval [CI], 0.06 to 0.42; p < 0.001) and OS (HR, 0.15; 95% CI, 0.05 to 0.45; p < 0.001). Compared to favorable/intermediate prognosis group, poor prognosis group had shorter median PFS (4.7 months vs. 7.6 months [HR, 2.91; 95% CI, 1.39 to 6.12; p=0.005]) and median OS (9.2 months vs. 17.6 months [HR, 2.84; 95% CI, 1.23 to 6.56; p=0.015]).
  • Conclusion
    Temsirolimus not only benefits poor-risk nccRCC patients, but it is also effective in favorable or intermediate-risk group in Asians. Temsirolimus was well-tolerated with manageable adverse events.
  • Key words: Temsirolimus, First-line, Asian, Renal cell carcinoma, Efficacy, Tolerability
Renal cell cancer (RCC) is a heterogeneous disease that is diversified by its pathologic subtypes, genetic alterations, and clinical outcomes [1,2]. It is mainly divided into two pathological subtypes based on pathologic phenotype, clear cell, and non-clear cell types, with the latter defined as less than 50% of clear cells [3].
The incidence of non-clear cell RCC (nccRCC) is no more than 8%-20% [4]. Its rarity and poor prognosis have made it difficult to determine the best treatment option. In recent years, tyrosine kinase inhibitors (TKIs) targeting vascular endothelial growth factor receptor (VEGFR) pathways, such as sunitinib [5,6] and sorafenib [7,8], and mammalian target of rapamycin (mTOR) inhibitors, such as temsirolimus [9,10] and everolimus [11,12], have been developed for the treatment of advanced/metastatic RCC [13]. Temsirolimus is an inhibitor of mTOR kinase, which is part of a signaling pathway associated with growth and proliferation of cells. Disruption of mTOR thereby results in suppression of cell cycle and angiogenesis [14,15].
Global Advanced Renal Cell Cancer (ARCC) phase 3 trial showed that 40 nccRCC treatment-naïve patients with poor prognosis, who received temsirolimus, had a median progression-free survival (mPFS) of 3.8 months and median overall survival (mOS) of 10.9 months. However, there is no data on the efficacy of temsirolimus in less extensive, relatively favorable and intermediate prognosis in nccRCC, especially in Asian patients.
The aim of this retrospective, multicenter prospective study is to investigate the efficacy and tolerability of temsirolimus in treatment-naïve Asian patients with metastatic/recurrent nccRCC.
1. Study design
This is a combined analysis of 44 patients from the prospective study and retrospectively collected cases. Data of 10 patients from prospective group were collected from five medical centers that participated in a non-randomized, phase II, multicenter prospective trial from May 2011 to February 2015. The study was closed prematurely when temsirolimus was approved by Ministry of Food and Drug Safety and reimbursed in South Korea on June 1, 2011, as the standard first-line treatment for metastatic/recurrent nccRCC. Then, 34 patients who received temsirolimus using the same protocol of the prospective study at Yonsei Cancer Center from January 2008 to July 2017 were retrospectively analyzed in conjunction with the prospective group.
The primary end-point was progression-free survival (PFS). Secondary end points were overall survival (OS), objective response rate (ORR), disease control rate, safety, and tolerability of temsirolimus.
2. Patient selection
Inclusion criteria included histologically confirmed nccRCC (papillary, chromophobe, collecting duct, Xp11.2 translocation, others as unclassified) defined as metastatic and recurrent stage IV with a measurable or evaluable lesion by Response Evaluation Criteria in Solid Tumors (RECIST); Eastern Cooperative Oncology Group (ECOG) performance status 0-2; and adequate liver, renal, bone marrow functions. Before enrollment, pathology including questionable cases was reviewed by a pathologist who specialized in urology pathology at Yonsei Cancer Center. Patients were ineligible if they had received any prior chemotherapy treatment for renal cell carcinoma.
3. Treatment and evaluation
The patients received 25 mg of temsirolimus administered in a weekly 30-minute intravenous infusion, and four weekly infusions were considered as one cycle. Treatment continued until unacceptable toxicity, disease progression, death, or patient’s withdrawal of consent. Doses were interrupted based on relevant hematologic and non-hematologic effects, according to National Cancer Center Institute-Common Terminology Criteria of Adverse Events (NCI-CTCAE v.4.0). Dose was not reduced if adverse events (AEs) could be managed with conservative care. Temsirolimus was withheld for a maximum of 3 weeks for grade 3 or 4 AEs, and restarted at a reduced dose after recovery to grade 2 or lower. Dose was reduced to 20 mg/m2 weekly, and there was no reduction of more than 15 mg/m2 weekly.
To evaluate tumor size, computed tomography was repeated every two cycles (4 weeks considered as one cycle) with RECIST criteria 1.1. In patients who were enrolled in the prospective study, chest computed tomography evaluation was performed at the time of baseline and 8 weeks after treatment to evaluate pulmonary toxicity, such as noninfectious pneumonitis. Both Memorial Sloan Kettering Cancer Center (MSKCC) and ARCC risk groups, with the latter including the criteria of metastatic lesions in ≥ 2 organs, were used to determine prognosis.
4. Statistics
Descriptive analysis was used to describe baseline characteristics and AEs. Survival curves were calculated using the Kaplan-Meier method. All statistical analyses were performed using SPSS statistical software ver. 25 (IBM Corp., Armonk, NY), SAS software ver. 9.4 (SAS Inc., Cary, NC), and R software ver. 3.5.0, (R Foundation for Statistical Computing, Vienna, Austria).
In prospective study, the following assumptions were made in the estimation of required sample size for primary end-point, PFS. The null hypothesis was that PFS (H0) is 3.1 months. H0 was estimated from the previous trial of interferon α with PFS of 3.1 months. If temsirolimus had PFS of less than 3.1 months, trial would not proceed. The alternative hypothesis (H1) was that PFS will be 5.5 months for treatment-naïve patients. This was based on the previous study of treatment-naïve and previously treated RCC patients who had similar PFS of 5.5 months and 6.3 months, respectively [13]. Sample size was calculated using Simon’s optimal two-stage design. With one-sided significance level of 0.05, a power of 0.9 to reject the null hypothesis, and a 10% drop-out rate, the final sample size was calculated to be 30 patients.
5. Ethical statement
This study was conducted in accordance with the Declaration of Helsinki, and was consistent with Good Clinical Practice. The institutional review board (IRB) of six centers approved the study protocol (IRB No. 4-2017-0727), and the study was registered in Korean Cancer Study Group (KCSG) (No: GU11-03). All patients from the retrospective cases were exempted from the written consent, according to the study protocol approved by IRB of Severance Hospital (IRB No. 4-2017-1056).
1. Patient characteristics
In this study, a total of 44 patients were enrolled; 10 from prospective group and 34 from retrospective group. Table 1 lists the baseline characteristics of patients. The median age was 52 years (range, 17 to 84 years), and 32 patients (73%) were male. Twenty-four patients (54%) were papillary type renal cell carcinoma (pRCC), and among them, 19 patients were categorized as type 2 pRCC (two patients had type 1 pRCC, three patients were not sub-classified). Other histology subtypes included 11 chromophobes (25%), two collecting ducts (5%), one Xp11.2 translocation (2%), and six others (14%). Thirteen patients (71%) had sarcomatoid components.
Thirty patients were initially diagnosed as stage IV, and two-thirds of the patients had nephrectomy, 19 for curative and 11 for cytoreductive purposes. Except for one patient who had local relapse, 43 patients had one or more metastatic sites such as lung, lymph node, bone, and liver metastasis. Most of the patients (80%) were treated within a year after initial diagnosis. When patients were categorized by risk groups, 15 patients were classified as poor-risk according to ARCC criteria and four patients by MSKCC criteria.
2. Efficacy
Out of 44 patients, 35 patients were evaluable. Three patients (9%) showed complete response, one patient (3%) showed partial response, and 25 patients (70%) showed stable disease, resulting in overall response rate (ORR) of 11% and disease control rate (DCR) of 83% (Table 2). The duration of response was at least 15 months (median, 29.2 months; 95% confidence interval [CI], 15.60 to 66.40) for all four respondents, and responses were maintained at the time of data analysis. At the time of analysis, 34 patients showed disease progression and 26 patients died. The cause of death was disease progression for 24 patients. The median PFS was 7.6 months (95% CI, 5.0 to 10.2) and median OS was 17.6 months (95% CI, 0 to 39.1) (Fig. 1).
The patients were further subdivided into pathological subtypes, sarcomatoid features, and prognosis groups. No significant difference in PFS or OS was observed in histological subtypes (Figs. 2 and 3). There was also no correlation between PFS and sarcomatoid features. However, patients without sarcomatoid features had longer OS (33.7 months) compared to patients with sarcomatoid features (9.2 months) (p=0.025). Poor prognosis group defined by ARCC criteria had a trend for shorter PFS and OS. PFS of poor prognostic group was 4.7 months compared to 19.3 months of favorable/intermediate group (p=0.005). OS was 9.2 months (95% CI, 1.23 to 6.56) in poor prognostic group and 43.1 months in favorable/intermediate group (p=0.015).
3. Safety and tolerability
Table 3 shows AEs. During treatment, 37 patients (84%) experienced one or more AEs. Thirty patients (68%) had symptoms/signs, and 27 patients (61%) had lab/imaging abnormalities that were related to temsirolimus. The most common AEs were stomatitis (34%), fatigue (27%), anorexia (18%), and rash (16%). The most frequent laboratory and imaging abnormalities were hyperglycemia (23%), hypercholesterolemia (18%), hypertriglyceridemia (16%), and noninfectious pneumonitis (16%). Particularly, AEs of grade > 3 were noted in stomatitis (9%), hypertriglyceridemia (11%), hyperglycemia (9%), and noninfectious pneumonitis (7%). Twenty-six patients (59%) who experienced AEs of grade 3 had dose reduction or delayed treatment. A total of four patients (9%) discontinued treatment due to stomatitis (one patient), noninfectious pneumonitis (two patients), and creatinine elevation (one patient). There was no treatment-related mortality.
The median duration of treatment was 11 weeks (ranging from 1 to 209). Thirteen patients (30%) had more than one dose reduction, and 15 patients (34%) had more than one dose delays.
4. Prognostic factors affecting survival
In univariate analysis, factors such as previous nephrectomy (p < 0.001) and favorable/intermediate prognosis defined by ARCC and MSKCC (p=0.005 and p=0.024, respectively) were associated with improved PFS (Table 4). Factors that were associated with poor OS were poor ECOG performance status (p=0.009), presence of sarcomatoid component (p=0.025), absence of previous nephrectomy (p < 0.001), and poor prognosis defined by ARCC and MSKCC (p=0.015 and p=0.004, respectively).
In multivariate Cox regression analysis, prognostic factor defined by ARCC was selected because it was the criteria used in the Global ARCC trial which showed that nccRCC with poor prognosis benefit from temsirolimus. MSKCC was disregarded in order to avoid interaction between the two parameters. Patients with prior nephrectomy tended to have better PFS (HR, 0.16; 95% CI, 0.06 to 0.42; p < 0.001). Sarcomatoid component (HR, 3.07; 95% CI, 1.12 to 8.39; p=0.029) and previous nephrectomy (HR, 0.15; 95% CI, 0.05 to 0.45; p < 0.001) were significantly associated with OS.
Notably, second-line treatment did not affect the OS. Only 11 patients (25%) received second-line chemotherapy which included eight patients who received TKIs such as pazopanib, sunitinib, axitinib, and three patients who received chemotherapy (Table 1). Therefore, our results suggested that temsirolimus as first-line of treatment was crucial in determining the OS of nccRCC.
This study included both prospective and retrospective data of temsirolimus as first-line treatment in treatmentnaïve Asian patients with metastatic/recurrent nccRCC. All of the 34 patients from retrospective group were treated with the same standard protocol from the prospective study at Yonsei Cancer Center. Since the majority of data was collected from a single center with consistent protocol, heterogeneity of data was minimized. Our results showed that patients had ORR of 11%, DCR 83%, mPFS of 7.6 months, and mOS of 17.6 months. When patients were further categorized by favorable/intermediate and poor prognosis group was defined by Hudes et al. [9] the mPFS and mOS for poor prognosis group were 4.7 and 9.2 months, respectively. These results are comparable to those of pivotal temsirolimus studies, particularly the Global ARCC trial.
Global ARCC trial, which was a randomized phase 3 study of temsirolimus versus interferon α or both for clear cell (586 patients) and nccRCC (40 patients), showed that patients defined as poor prognosis who were administered with temsirolimus had mPFS of 3.8 months and mOS of 10.9 months. Thus, temsirolimus has been used as standard treatment for nccRCC with poor prognosis. In our study, one-third of the patients were classified as poor-risk, which may explain why our study had longer mPFS and mOS. Therefore, temsirolimus may not only benefit poor prognosis group, but also patients with less extensive metastatic nccRCC. It is important to note that there were more patients who were categorized as poor prognostic group by ARCC (15 patients, 34%) than with MSKCC parameters (four patients, 9%). Since MSKCC parameters have certain limitations in nccRCC, our study focused on the prognostic tool defined by Hudes et al. [9] in Global ARCC trial asreference data. IDMC model (International Metastatic Renal Cell Carcinoma) which was validated in ccRCC VEGFR TKI but not in nccRCC, was also not considered in this study.
Everolimus, an orally administered mTOR inhibitor in nccRCC, was also evaluated in ESPN (Everolimus versus Sunitinib Prospective Evaluation in Metastatic Non-clear Cell Renal Cell Carcinoma) [11] and ASPEN [12] studies. ESPN, a randomized phase 2 study compared the efficacy of everolimus and sunitinib in first-line setting in 73 subjects. Sunitinib, a vascular endothelial growth factor TKI, had better mPFS than that of everolimus (6.1 months vs, 4.1 months, p=0.25) [11]. Similarly, everolimus versus sunitinib for patients with metastatic nccRCC (ASPEN), a randomized phaseII study of 108 subjects, showed that sunitinib and everolimus had a median PFS of 8.3 months and 5.6 months, respectively [12].
Based on these results, everolimus cannot be recommended in first-line treatment for nccRCC. On the other hand, the efficacy of temsirolimus if comparable to tha of sunitinib. Although temsirolimus has its limitation with weekly intravenous injection compared to relatively easy oral administration of sunitinib, temsirolimus has better manageable toxicity profiles compared to sunitinib. In our study, 84% (37 patients) of subjects experienced AEs and 59% (26 patients) has grade 3-related AEs, which were manageable with dose reductions and dose delays. Only four patients (9%) discontinued treatment due to AEs.
In ASPEN study, 78% (40 patients) receiving sunitinib experenced grade 3 or worse treatment-related AEs. Overall, 53% (27 patients) needed does reductions and 14% (7 patients) discontinued treatment due to treatment-related AEs. AEs related to sunitinib included hypertension, hard-foot syndrome, nausea/vomiting, diarrhea, and lab abnormalities such as hypothyroidism, thrombocytopenia, neutropenia, and elevated liver enzymes [12].
Pazopanib a VEGFR TKI which was approved in advanced ccRCC, was also investigated in first-line setting in nccRCC. First-line pazopanib in nccRCC (PANORAMA) study which enrolled 37 patients, resulted in mPFS of 15.9 months and mOS of 17.3 months [16]. Pazobanib as second-line in 29 patients treated had an ORR of 28% with mPFS 16.5 months [17]. Pazobanib's role in nccRCC may need furthervalidation. Table 5 summarizes ARCC, ESPN, ASPEN, and PANORAMA results.
Although recent advancements have led to the development of new targeted drugs such as cabozantinib [18], a multi-targeted TKI and immune checkpoint inhibitors such as nivolumab in ccRCC, efficacy results on nccRCC are currently being investigated. The limitation of this study was the lack of data collected on parameters, such as lactate dehydrogenase, and a part of toxicity profiles in retrospective data. In addition, low incidence of nccRCC and reimbursement issues were obstacles in collecting larger sample size.
In conclusion, there seem to be several treatment options for nccRCC. Although temsirolimus and everolimus are both mTOR inhibitors, everolimus has failed to improve PFS and OS. Sunitinib and pazopanib are both VEGFR TKIs, but pazopanib as first-line nccRCC lacks data. Although 75% (33 patients) did not receive second-line therapy due to fewer treatments options in South Korea, mOS was 17.6 months, indicating that the effect of temsirolimus directly translates to OS. In addition, temsirolimus not only benefits poor-risk group but also the favorable or intermediate-risk groups, and has comparable results to those of sunitinib.
Less extensive metastatic nccRCC may benefit from temsirolimus, regardless of histological variations and risk factors. Additional studies with larger sample size of nccRCC are needed to validate the results of this study.

Conflict of interest relevant to this article was not reported.

Acknowledgements
Prospective part of the study was endorsed by Korean Cancer Study Group (KCSG, www.kcsg.org) (GU11-03).
This research was partly supported by a grant from the National R&D Program for Cancer Control, Ministry of Health and Welfare, Republic of Korea (1720150) and the National Cancer Center, Republic of Korea (NCC-1810861-1).
Fig. 1.
Efficacy of temsirolimus in non-clear cell renal cell carcinoma. (A) Progression-free survival (PFS). (B) Overall survival (OS). CI, confidence interval.
crt-2018-671f1.jpg
Fig. 2.
Kaplan-Meier curves of progression-free survival (PFS) according to subgroups. (A) With or without sarcomatoid features. (B) Papillary, chromophobe, others. (C) Prognostic group by Advanced Renal Cell Cancer criteria. HR, hazard ratio; CI, confidence interval.
crt-2018-671f2.jpg
Fig. 3.
Kaplan-Meier curves of overall survival (OS) according to subgroups. (A) With or without sarcomatoid features. (B) Papillary, chromophobe, others. (C) Prognostic group by Advanced Renal Cell Cancer criteria. HR, hazard ratio; CI, confidence interval.
crt-2018-671f3.jpg
Table 1.
Baseline characteristics
Variable No. (%) (n=44)
Age, median (range) 52 (17-84)
Sex
 Male 32 (73)
 Female 12 (23)
Histology
 Papillary 24 (54)
 Chromophobe 11 (25)
 Collecting duct 2 (5)
 Xp11.2 translocation 1 (2)
 Others 6 (14)
Sarcomatoid component
 Yes 13 (29)
 No 31 (71)
Initial stage of diagnosis
 I 5 (11)
 II 3 (7)
 III 6 (14)
 IV 30 (68)
Previous nephrectomy
 Curative 19 (43)
 Cytoreductive 11 (25)
Previous radiotherapy
 Yes 2 (5)
 No 42 (95)
No. of metastatic sites
 0 1 (2)
 1 26 (59)
 2 11 (25)
 ≥ 3 6 (14)
Sites of metastatic disease
 Lung 17 (39)
 Lymph node 18 (41)
 Bone 12 (27)
 Liver 9 (21)
ARCC parameter
 Low hemoglobina) 26 (59)
 Elevated calcium > 10 mg/dL (> 2.5 mmol/L) 2 (5)
 Elevated LDH 7 (16)
 Performance status < 80% 3 (7)
 Time from diagnosis to systemic treatment < 1 yr 32 (73)
 No. of metastatic sites ≥ 2 17 (39)
ECOG
 0 33 (75)
 1 8 (18)
 2 3 (7)
ARCC
 Favorable (0) 5 (11)
 Intermediate (1-2) 24 (55)
 Poor (≥ 3) 15 (34)
MSKCC
 Favorable (0) 6 (14)
 Intermediate (1-2) 34 (77)
 Poor (≥ 3) 4 (9)
2nd-line treatment
 Yes 11 (25)
 No 33 (75)

ARCC, Advanced Renal Cell Cancer; LDH, lactate dehydrogenase; ECOG, Eastern Cooperative Oncology Group; MSKCC, Memorial Sloan Kettering Cancer Center.

a) Men < 13.5g/dL, women < 12.0 mg/dL.

Table 2.
Summary of response
No. of evaluable patients (%) (n=35)
Best response
 CR 3 (9)
 PR 1 (3)
 SD 25 (70)
 PD 6 (18)
 Response rate (CR+PR) 4 (11)
 Disease control rate (CR+PR+SD) 29 (83)
Duration of treatment, median (range, wk) 11 (1-209)
Patients with ≥ 1 dose reduction-number 13 (30)
Patients with ≥ 1 dose delay-number 15 (34)

CR, complete response; PR, partial response; SD, stable disease; PD, progressive disease.

Table 3.
Summary of treatment-related adverse events
No. of patients (%)
All grades Grade ≥ 3 All grades Grade ≥ 3 All grades Grade ≥ 3
Symptoms and signs (n=30, 68%)
 Anorexia 5 (15) 2 (6) 3 (30) - 8 (18) 2 (5)
 Nausea/Vomiting 2 (6) 1 (3) 1 (10) - 3 (7) 1 (2)
 Fatigue 8 (24) 2 (6) 4 (40) 3 (30) 12 (27) 5 (11)
 Stomatitis 10 (30) 1 (3) 5 (50) 3 (30) 15 (34) 4 (9)
 Hand-foot syndrome 3 (9) - - - 3 (7) -
 Rash 5 (15) - 2 (20) 1 (10) 7 (16) 1 (2)
 Pruritus 2 (6) - 3 (30) - 5 (11) -
 Headache 1 (3) - 1 (10) - 2 (5) -
 Alopecia 1 (3) - - - 1 (2) -
 Edema 1 (3) - 2 (20) - 3 (7) -
 Scrotal swelling - - 1 (10) - 1 (2) -
 Leg pain - - 2 (20) - 2 (5) -
 URI 3 (9) - 2 (20) - 5 (11) -
 Diarrhea - - 1 (10) - 1 (2) -
 Insomnia - - 1 (10) - 1 (2) -
Lab and imaging abnormalities (n=27, 61%)
 Anemia 3 (9) - - - 1 (2) -
 Leukopenia 1 (3) - 2 (20) 1 (10) 3 (7) -
 Thrombocytopenia - - 1 (10) - 1 (2) -
 Increased AST/ALT 2 (6) - 1 (10) - 3 (7) -
 Increased creatinine level 1 (3) - 1 (10) - 2 (5) -
 Hyperglycemia 10 (30) 4 (12) - - 10 (23) 4 (9)
 Hypercholesterolemia 6 (18) - 2 (20) - 8 (18) -
 Hypertriglyceridemia 5 (15) 4 (12) 2 (20) 1 (10) 7 (16) 5 (11)
 Noninfectious pneumonitis 7 (21) 1 (3) - - 7 (16) 1 (2)

URI, upper respiratory tract infection; AST, aspartate aminotransferase; ALT, alanine aminotransferase.

Table 4.
Univariate and multivariate Cox regression analyses of PFS and OS
Variable PFS
 OS
Univariate analysis
 Multivariate analysis
 Univariate analysis
 Multivariate analysis
HR 95% CI p-value HR 95% CI p-value HR 95% CI p-value HR 95% CI p-value
Age (yr)
 < 55 Reference 0.260 Reference 0.365
 ≥ 55 1.49 0.78-2.96 1.43 0.66-3.09
Sex
 Male Reference 0.714 Reference 0.373
 Female 1.16 0.54-2.50 1.45 0.64-3.36
ECOG
 0 Reference 0.070 Reference 0.979 Reference 0.009 Reference 0.311
 1 0.58 0.22-1.51 0.93 0.34-2.57 0.25 0.06-1.05 0.32 0.07-1.39
 2 4.46 0.95-20.91 1.13 0.23-5.60 6.61 1.34-32.53 1.18 0.21-6.68
Histology
 Papillary Reference 0.420 Reference 0.381
 Chromophobe 0.72 0.30-1.72 0.85 0.33-2.24
 Others 1.46 0.61-3.49 1.80 0.69-4.70
Sarcomatoid component
 No Reference 0.119 Reference 0.025 Reference 0.029
 Yes 1.81 0.86-3.81 2.53 1.12-5.72 3.07 1.12-8.39
Previous nephrectomy
 No Reference < 0.001 Reference < 0.001 Reference < 0.001 Reference < 0.001
 Yes 0.17 0.08-0.37 0.16 0.06-0.42 0.22 0.09-0.51 0.15 0.05-0.45
Previous RT
 No Reference - Reference 0.647
 Yes 1.08 0.26-4.55 0.921 0.63 0.08-4.66
No. of metastatic sites
 0 or 1 Reference 0.089 Reference 0.225 Reference 0.088 Reference 0.259
 ≥ 2 1.82 0.91-3.62 1.77 0.70-4.46 1.97 0.90-4.26 1.88 0.63-5.66
ARCC
 Favorable/Intermediate Reference 0.005 Reference 0.457 Reference 0.015 Reference 0.650
 Poor 2.92 1.39-6.12 1.46 0.54-3.97 2.84 1.23-6.57 0.74 0.20-2.73
MSKCC
  Favorable/Intermediate Reference 0.024 Reference 0.004
 Poor 3.67 1.19-11.33 3.41 1.50-7.76
Second-line treatment
 No Reference 0.948 Reference 0.352
 Yes 0.98 0.46-2.06 0.65 0.26-1.62

PFS, progression-free survival; OS, overall survival; HR, hazard ratio; CI, confidence interval; ECOG, Eastern Cooperative Oncology Group; RT, radiotherapy; ARCC, Advanced Renal Cell Cancer; MSKCC, Memorial Sloan Kettering Cancer Center.

Table 5.
Summary of first-line therapy for metastatic nccRCC
Study Our study ARCC [9] ESPN [11] ASPEN [12] PANORAMA [16]
No. of nccRCCs 44 124 73 108 37
Treatment Temsirolimus Temsirolimus (40) Sunitinib (34) vs. Everolimus (38) Sunitinib (51) vs. Everolimus (57) Pazopanib
Prognosis Any Poor Mostly favorable, intermediate Any Any
ORR (%) 9 8.6 12 vs. 0 12 vs. 5.0 27
PFS (mo) 7.6 3.8 6.1 vs. 4.1 8.3 vs. 5.6 15.9
OS (mo) 17.6 10.9 16.2 vs. 14.9 (p=0.18) 31.5 vs. 13.2 (p=0.60) 17.3

nccRCC, non-clear cell renal cell carcinoma; ARCC, Advanced Renal Cell Cancer; ESPN, Everolimus versus Sunitinib Prospective Evaluation in Metastatic Non-clear Cell Renal Cell Carcinoma; ASPEN, Everolimus versus Sunitinib for Patients with Metastatic Non-clear Cell Renal Cell Carcinoma; PANORAMA, first-line pazopanib in nccRCC; ORR, objective response rate; PFS, progression-free survival; OS, overall survival.

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      Temsirolimus in Asian Metastatic/Recurrent Non-clear Cell Renal Carcinoma
      Cancer Res Treat. 2019;51(4):1578-1588.   Published online April 16, 2019
      DOI: https://doi.org/10.4143/crt.2018.671
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    Temsirolimus in Asian Metastatic/Recurrent Non-clear Cell Renal Carcinoma
    Image Image Image
    Fig. 1. Efficacy of temsirolimus in non-clear cell renal cell carcinoma. (A) Progression-free survival (PFS). (B) Overall survival (OS). CI, confidence interval.
    Fig. 2. Kaplan-Meier curves of progression-free survival (PFS) according to subgroups. (A) With or without sarcomatoid features. (B) Papillary, chromophobe, others. (C) Prognostic group by Advanced Renal Cell Cancer criteria. HR, hazard ratio; CI, confidence interval.
    Fig. 3. Kaplan-Meier curves of overall survival (OS) according to subgroups. (A) With or without sarcomatoid features. (B) Papillary, chromophobe, others. (C) Prognostic group by Advanced Renal Cell Cancer criteria. HR, hazard ratio; CI, confidence interval.

    Fig. 1.

    Fig. 2.

    Fig. 3.

    Temsirolimus in Asian Metastatic/Recurrent Non-clear Cell Renal Carcinoma
    Variable No. (%) (n=44)
    Age, median (range) 52 (17-84)
    Sex
     Male 32 (73)
     Female 12 (23)
    Histology
     Papillary 24 (54)
     Chromophobe 11 (25)
     Collecting duct 2 (5)
     Xp11.2 translocation 1 (2)
     Others 6 (14)
    Sarcomatoid component
     Yes 13 (29)
     No 31 (71)
    Initial stage of diagnosis
     I 5 (11)
     II 3 (7)
     III 6 (14)
     IV 30 (68)
    Previous nephrectomy
     Curative 19 (43)
     Cytoreductive 11 (25)
    Previous radiotherapy
     Yes 2 (5)
     No 42 (95)
    No. of metastatic sites
     0 1 (2)
     1 26 (59)
     2 11 (25)
     ≥ 3 6 (14)
    Sites of metastatic disease
     Lung 17 (39)
     Lymph node 18 (41)
     Bone 12 (27)
     Liver 9 (21)
    ARCC parameter
     Low hemoglobina) 26 (59)
     Elevated calcium > 10 mg/dL (> 2.5 mmol/L) 2 (5)
     Elevated LDH 7 (16)
     Performance status < 80% 3 (7)
     Time from diagnosis to systemic treatment < 1 yr 32 (73)
     No. of metastatic sites ≥ 2 17 (39)
    ECOG
     0 33 (75)
     1 8 (18)
     2 3 (7)
    ARCC
     Favorable (0) 5 (11)
     Intermediate (1-2) 24 (55)
     Poor (≥ 3) 15 (34)
    MSKCC
     Favorable (0) 6 (14)
     Intermediate (1-2) 34 (77)
     Poor (≥ 3) 4 (9)
    2nd-line treatment
     Yes 11 (25)
     No 33 (75)
    No. of evaluable patients (%) (n=35)
    Best response
     CR 3 (9)
     PR 1 (3)
     SD 25 (70)
     PD 6 (18)
     Response rate (CR+PR) 4 (11)
     Disease control rate (CR+PR+SD) 29 (83)
    Duration of treatment, median (range, wk) 11 (1-209)
    Patients with ≥ 1 dose reduction-number 13 (30)
    Patients with ≥ 1 dose delay-number 15 (34)
    No. of patients (%)
    All grades Grade ≥ 3 All grades Grade ≥ 3 All grades Grade ≥ 3
    Symptoms and signs (n=30, 68%)
     Anorexia 5 (15) 2 (6) 3 (30) - 8 (18) 2 (5)
     Nausea/Vomiting 2 (6) 1 (3) 1 (10) - 3 (7) 1 (2)
     Fatigue 8 (24) 2 (6) 4 (40) 3 (30) 12 (27) 5 (11)
     Stomatitis 10 (30) 1 (3) 5 (50) 3 (30) 15 (34) 4 (9)
     Hand-foot syndrome 3 (9) - - - 3 (7) -
     Rash 5 (15) - 2 (20) 1 (10) 7 (16) 1 (2)
     Pruritus 2 (6) - 3 (30) - 5 (11) -
     Headache 1 (3) - 1 (10) - 2 (5) -
     Alopecia 1 (3) - - - 1 (2) -
     Edema 1 (3) - 2 (20) - 3 (7) -
     Scrotal swelling - - 1 (10) - 1 (2) -
     Leg pain - - 2 (20) - 2 (5) -
     URI 3 (9) - 2 (20) - 5 (11) -
     Diarrhea - - 1 (10) - 1 (2) -
     Insomnia - - 1 (10) - 1 (2) -
    Lab and imaging abnormalities (n=27, 61%)
     Anemia 3 (9) - - - 1 (2) -
     Leukopenia 1 (3) - 2 (20) 1 (10) 3 (7) -
     Thrombocytopenia - - 1 (10) - 1 (2) -
     Increased AST/ALT 2 (6) - 1 (10) - 3 (7) -
     Increased creatinine level 1 (3) - 1 (10) - 2 (5) -
     Hyperglycemia 10 (30) 4 (12) - - 10 (23) 4 (9)
     Hypercholesterolemia 6 (18) - 2 (20) - 8 (18) -
     Hypertriglyceridemia 5 (15) 4 (12) 2 (20) 1 (10) 7 (16) 5 (11)
     Noninfectious pneumonitis 7 (21) 1 (3) - - 7 (16) 1 (2)
    Variable PFS
    		 OS
    Univariate analysis
    		 Multivariate analysis
    		 Univariate analysis
    		 Multivariate analysis
    HR 95% CI p-value HR 95% CI p-value HR 95% CI p-value HR 95% CI p-value
    Age (yr)
     < 55 Reference 0.260 Reference 0.365
     ≥ 55 1.49 0.78-2.96 1.43 0.66-3.09
    Sex
     Male Reference 0.714 Reference 0.373
     Female 1.16 0.54-2.50 1.45 0.64-3.36
    ECOG
     0 Reference 0.070 Reference 0.979 Reference 0.009 Reference 0.311
     1 0.58 0.22-1.51 0.93 0.34-2.57 0.25 0.06-1.05 0.32 0.07-1.39
     2 4.46 0.95-20.91 1.13 0.23-5.60 6.61 1.34-32.53 1.18 0.21-6.68
    Histology
     Papillary Reference 0.420 Reference 0.381
     Chromophobe 0.72 0.30-1.72 0.85 0.33-2.24
     Others 1.46 0.61-3.49 1.80 0.69-4.70
    Sarcomatoid component
     No Reference 0.119 Reference 0.025 Reference 0.029
     Yes 1.81 0.86-3.81 2.53 1.12-5.72 3.07 1.12-8.39
    Previous nephrectomy
     No Reference < 0.001 Reference < 0.001 Reference < 0.001 Reference < 0.001
     Yes 0.17 0.08-0.37 0.16 0.06-0.42 0.22 0.09-0.51 0.15 0.05-0.45
    Previous RT
     No Reference - Reference 0.647
     Yes 1.08 0.26-4.55 0.921 0.63 0.08-4.66
    No. of metastatic sites
     0 or 1 Reference 0.089 Reference 0.225 Reference 0.088 Reference 0.259
     ≥ 2 1.82 0.91-3.62 1.77 0.70-4.46 1.97 0.90-4.26 1.88 0.63-5.66
    ARCC
     Favorable/Intermediate Reference 0.005 Reference 0.457 Reference 0.015 Reference 0.650
     Poor 2.92 1.39-6.12 1.46 0.54-3.97 2.84 1.23-6.57 0.74 0.20-2.73
    MSKCC
      Favorable/Intermediate Reference 0.024 Reference 0.004
     Poor 3.67 1.19-11.33 3.41 1.50-7.76
    Second-line treatment
     No Reference 0.948 Reference 0.352
     Yes 0.98 0.46-2.06 0.65 0.26-1.62
    Study Our study ARCC [9] ESPN [11] ASPEN [12] PANORAMA [16]
    No. of nccRCCs 44 124 73 108 37
    Treatment Temsirolimus Temsirolimus (40) Sunitinib (34) vs. Everolimus (38) Sunitinib (51) vs. Everolimus (57) Pazopanib
    Prognosis Any Poor Mostly favorable, intermediate Any Any
    ORR (%) 9 8.6 12 vs. 0 12 vs. 5.0 27
    PFS (mo) 7.6 3.8 6.1 vs. 4.1 8.3 vs. 5.6 15.9
    OS (mo) 17.6 10.9 16.2 vs. 14.9 (p=0.18) 31.5 vs. 13.2 (p=0.60) 17.3
    Table 1. Baseline characteristics

    ARCC, Advanced Renal Cell Cancer; LDH, lactate dehydrogenase; ECOG, Eastern Cooperative Oncology Group; MSKCC, Memorial Sloan Kettering Cancer Center.

    Men < 13.5g/dL, women < 12.0 mg/dL.

    Table 2. Summary of response

    CR, complete response; PR, partial response; SD, stable disease; PD, progressive disease.

    Table 3. Summary of treatment-related adverse events

    URI, upper respiratory tract infection; AST, aspartate aminotransferase; ALT, alanine aminotransferase.

    Table 4. Univariate and multivariate Cox regression analyses of PFS and OS

    PFS, progression-free survival; OS, overall survival; HR, hazard ratio; CI, confidence interval; ECOG, Eastern Cooperative Oncology Group; RT, radiotherapy; ARCC, Advanced Renal Cell Cancer; MSKCC, Memorial Sloan Kettering Cancer Center.

    Table 5. Summary of first-line therapy for metastatic nccRCC

    nccRCC, non-clear cell renal cell carcinoma; ARCC, Advanced Renal Cell Cancer; ESPN, Everolimus versus Sunitinib Prospective Evaluation in Metastatic Non-clear Cell Renal Cell Carcinoma; ASPEN, Everolimus versus Sunitinib for Patients with Metastatic Non-clear Cell Renal Cell Carcinoma; PANORAMA, first-line pazopanib in nccRCC; ORR, objective response rate; PFS, progression-free survival; OS, overall survival.

    Table 1.

    Table 2.

    Table 3.

    Table 4.

    Table 5.

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