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J Korean Cancer Assoc > Volume 28(6); 1996 > Article
Journal of the Korean Cancer Association 1996;28(6): 1083-1092.
신세포암 환자에서 Interleukin-6 의 생산성과 임상적 의의
장성구, 이선주, 박재경
Clinical Significance of Interleukin-6 and its Production in Patients with Renal Cell Carcinoma
Sung Goo Chang, Sun Ju Lee, Jai Kyung Park
Interleukin-6(IL-6) is a multifunctional cytokine with many biologic activities in vitro, including synergistic or antagonistic actions with one ar more other cytokines. The role and induction parameter of IL-6 in renal cell carcinoma(RCC) are not fully understood. To understand the capabilities of RCC to produce IL-6 and its clinical significance, we have determined the IL-6 level in the serum and urine of RCC patient at pre-treatment and during post-treatment follow up. From the results of study, we conclude there was no correlation observed between serum IL-6 level and tumor size or disease progression of RCC. There was no correlation between level of serum IL-6 and urine IL-6. The urine IL-6, however, was increased in case of renal vein thrombosis or renal capsular invasion and it was mainly increased at before operation. The IL-6 of serum and urine in patients was markedly increased after angioinfarction of RCC. There was no correlation between serum IL-6 level and synthesis of serum C-reactive protein. Therefore, measurement of urine IL-6 at preoperative period will be have more significance than those of serum IL-6 in patient with renal cell carcinoma.
Key words: Renal cell carcinoma, Interleukin-6, C-reactive protein
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