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J Korean Cancer Assoc > Volume 28(5); 1996 > Article
Journal of the Korean Cancer Association 1996;28(5): 888-897.
후두암 , 식도암 및 위암이 동시에 병발한 삼중복암 1 예
권교선, 김경태, 김용조, 성주병, 이영우, 장은정, 류백렬, 김태유, 임영혁, 강윤구, 이승숙, 이진오, 강태웅
A Case of Synchronous Triple Primary Cancers in Larynx , Esophageu , and Stomach
Gyo Seon Kwun, Kyung Tae Kim, Yong Cho Kim, Ju Byeung Sung, Young Wo Lee, Eun Jung Jang, Baek Yeol Ryoo, Tae You Kim, Young Hyuck Im, Yoon Koo Kang, Seung sook Lee, Jim Oh Lee, Tae Woong Kang
ABSTRACT
Multiple primary cancers can occur in up to 20% of primary aerodigestive tract cancer patients. The multiplicity of cancer in aerodigestive tract suggests that the exposure to common carcinogen may be the cause of multiplicity(field cancerization). Continuous alcohol drinking and smoking are considered to be the major factors in development of multiple cancers. Also, high frequency of genetic alterations in multiple primary cancer patients implys that the genetic instability such as replication error or mutation of tumor suppressor gene may play a role in the development of multiple primary cancers. We report a case of a 61 year-old man who had triple synchronous cancers in larynx, esophagus, and stomach. He was a heavy smoker of 30-pack-years and a heavy drinker. Pathological examination showed squamous cell carcinoma of larynx and esophagus, and adenocarrinoma of stomach, respectively.
Key words: Multiple primary malignant neoplasms, Larynx, Esophagus, Stomach
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