| 진행성 식도암에 대한 5-FU 및 Cisplatin ( FP ) 복합화학요법 |
| 우인숙, 정경해, 박영이, 이정애, 허대석, 방영주, 김노경 |
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| 5-Fluorouracil and Cisplatin ( FP ) Combination Chemotherapy in Advanced Esophageal Cancer |
| In Sook Woo, Kyung Hae Jung, Young Iee Park, Jung Ae Rhee, Dae Seog Heo, Yung Jue Bang, Noe Kyeong Kim |
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| ABSTRACT |
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Esophageal Carcinoma is widely disseminated in many patients at the time of diagnosis. Therefore systemic chemotherapy has assumed an important role in the treatment of this disease. We conducted a phase II trial of 5-fluorouracil and cisplatin in 39 patients with advanced esophageal cancer. The regimen consisted of 5-fluorouracil, 1,000 mg/§³/day in 12 hour continuous infusion on day 1 to 5 and cisplatin, 60 mg/§³/day iv on day 1 every three weeks. Response rates were calculated only from 37 patients with measurable disease. The response rate was 39%(complete response 2%, partial response 37%) with a median duration of 4 months (range 2~10 months). Median time of survival for all patients was 9 months(range 1~4 months). The toxicities were moderate. This study demonstrates that combination of 5-fluoriuracil and cisplatin is an efficient and tolerable chemotherapy regimen in patients with advanced esophageal cancer. |
| Key words:
Esophagus, Squamous cell carcinoma, 5-fluorouracil, Cisplatin |
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