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J Korean Cancer Assoc > Volume 28(4); 1996 > Article
Journal of the Korean Cancer Association 1996;28(4): 772-776.
소세포폐암에 동반된 근무력증후근 1 예
박종석, 조세행, 박재민, 김주항, 노재경, 장준, 선우일남, 김성균, 이원영
A Case of Lambert - Eaton Myasthenic Syndrome with Small Cell Lung Charcinoma
Chong Seog Park, Se Haeng Cho, Jae Min Park, Joo Hang Kim, Jae Kyung Roh, Joon Chang, Il Nam SunWoo, Sung Kyu Kim, Won Young Lee
The Lambert-Eaton myasthenic syndrome(LEMS) is a rare disorder of neuro-muscular transmission that is frequently associated with malignancy, particulary small cell carcinoma of the lung. We report a case of 66 year old man who complained of muscle weakness and fatigability of proximal lower limbs on the tappering af prednisolone administeredfor usual interstitial pneumonitis. He was diagnosed LEMS by electrophysiological studies and small cell lung carcinoma by cytologic examination of brochoscopicwashing. The electrophysiological studies support the clinical diagnosis of LEMS with ¨c low amplitude of evoked compound muscle potential to a single supra-maximal stimulus an nerve, ¨e significant decremental response at low rates of stimulation and ¨e marked incremental response at high rates of stimulation.
Key words: Lambert-Eaton myasthenia syndrome, Small cell lung carcinoma, Electrophysiologic study
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