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J Korean Cancer Assoc > Volume 28(4); 1996 > Article
Journal of the Korean Cancer Association 1996;28(4): 705-710.
악성 흉막유출에서 섬유소용해계 물질의 변화
백승호, 전진우, 원종호, 홍대식, 박희숙
Fibrinolytic Profiles in Malignant Pleural Effusion
Seung Ho Baik, Jin Woo Jeon, Jong Ho Won, Dae Sik Hong, Hee Sook Park
Plasminogen activators(PAs) and their inhibitors, plasminogen activator inhibitor-l(PAI-l) are known to play an important role in tumor invasion and metastasis. The differentiation of malignant pleural effusion(PE) from non-malignant pleural effusion is important for the management of a patient. Since malignant PE is a form of metastasis, and malignant cells are considered to be able to produce PAs or PAI-1, it seems reasonable to assume that PAa and PAI-1 in PE will be in somewhat different from that in non-malignant PE. We examined urokinase- type plasminogeo activator(uPA) and uPA receptor(uPAR) and tissue-type plasminogen activator(tPA), PAI-1 antigen using ELISA method and conventional laboratory tests and adenosine deaminase(ADA) in PEs. Levels of uPA, uPAR, tPA and PAI-1 were significantly increased in malignant and tuberculous PE than transudates(p<0.05) but not statistically significant between malignant and tuberculous PE. ADA in PE showed significantly increased in tuberculous PE than malignant PE and transudate(p<0.05). These data suggests that measurement of uPA, uPAR, tPA, PAI-1 antigen in addition to ADA could be helpful to differentiate malignant PE from tuberculous PE and transudate.
Key words: Malignant pleural effusion, Plasminogen activators and Plasminogen activator inhibitor-1
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