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J Korean Cancer Assoc > Volume 28(3); 1996 > Article
Journal of the Korean Cancer Association 1996;28(3): 411-418.
위암 세포내에서 Transforming Growth Factor Beta1 and Bate2 ( TGFβ1 and β2 ) 의 세포내 분포에 관한 면역세포화학적 연구
Immunoelectron Microscopic Localization of Transforming Growth Factor Beta1 and Bate2 in Human Gastric Carcinoma Cells
Young Euy Park
Immunohistochemical and immunoelectron microscopic studies were performed using specific monoclonal antibodies to transforming growth factor(TGF)-¥al, ¥a2 to determine their presence and cellular localization in human gastric adenocarinoma cells. Specific immunostaining was clearly detected in the cytoplasm of the neoplastic cells. The TGP-¥al, -¥a2 expression in the gastric adenocarcinoma is closely related to the depth of invasion, the degree of invasiveness and the presence of metastasis. In immuno-electron microscopy by 10nm gold particles, there are TGF¥a1, -¥a2 lacalized predominantly in the cytoplasm of the neoplastic cells. The gold particles were present within the secretory granules. The TGF-¥al, ¥a2 are not present in the cytoplasmic organells such as Golgi apparatus, mitachontria or rough endoplasmic reticulum.
Key words: Gastric adenocarcinoma, TGF-¥a Immunoelectron microscopic localization
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