Renal cell carcinoma accounts for 85% of all primary renal neoplasm. Its most common sites of distant metastses include lung, 1iver, bone, central nervous system, soft tissue. The treatment of metastatic renal cell carcinoma remain a major problem in clinical medicine. Hormonal therapies, chemotherapies or in combinations, and immunotherapic approaches to this tumor seldom result in objective tumor regression or prolongation of survival and the response are usually temporary. Fewer than 1% of patients with renal cell carcinoma are reported to experience spontaneous regression of metastatic lesions after nephrectomy. We report a case of spontaneous regression of metastatic renal cell carcinoma, which showed bilateral multiple lung metastases, multiple bone involvements, and subcutaneous nodules, with the review of literatures.
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