| Home | E-Submission | Sitemap | Contact Us |  
J Korean Cancer Assoc > Volume 28(2); 1996 > Article
Journal of the Korean Cancer Association 1996;28(2): 326-336.
근침윤성 Grade 3 방광암의 방광전적출술전 nm23-H1 과 p53 단백발현을 이용한 림프절 전이의 예측
박동수, 이진무
Prediction of Lymph Node Metastasis Based on p53 and nm23-H1 Expression in Muscle Invasive Grade 3 Transitional Cell Carcinoma of Bladder
Dong Soo Park, Jin Moo Lee
Objecetive: Surgically positive lymph node in invasive bladder cancer generally imply distant micrometastasis, thus preoperative identification of lymph node status is important. Various antioncoproteins were evaluated for their validity of predicting lymph node metastasis. Subjects and
57 cases who had invasive, grade III(WHO) transitonal cell carcinoma at transurethral resection of bladder(TURB), and then confirmed to have stage T2, T3a, and T3b tumor after radical cystectomy from 1985 to 1994 were selected. Tissues acquired from transurethral resection were immunostained with tumor suppressor gene p53(DO7 and PAb1801) and antimetastatic gene nm23-Hl(NM301). Results of staining and pathological stagings were compared with the status of lymph node metastasis. Reault: Expression of p53 was 42.1% (24/57) for DO7 and 22.8% (13/57) for PAbl801, DO7 exhibiting superiority over PAbl801. Expresion of nm23-Hl was seen in 50.9% (29/57). Combined analysis of p53 and nm23-Hl expression and nodal status(N stage) was not significant. However pathological nodal status was statistically significantly correlated with pathological tumor(T) stage and p53 expression. Conclnsion: ¨c High risk of lymph node metastasis can be predicted when Grade III, muscle invasive tumor and p53 expression is seen from TURB specimen.¨e Lymph node metastasis is correlated with the degree of invasion in Grade III muscle invasive tumor, and especially in T3b tumors, where there is highest probability of node involvement.
Key words: Invasive bladder cancer, Lymph node metastasis, p53, nm23-Hl
Editorial Office
Korean Cancer Association
Room 1824, Gwanghwamun Officia
92 Saemunan-ro, Jongno-gu, Seoul 03186, Korea
TEL: +82-2-3276-2410   FAX: +82-2-792-1410   E-mail: journal@cancer.or.kr
About |  Browse Articles |  Current Issue |  For Authors and Reviewers
Copyright © Korean Cancer Association.                 Developed in M2PI